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Table 2 Association between SNPs in WNT-associated genes and type 2 diabetes and related traits in MDCS

From: Several type 2 diabetes-associated variants in genes annotated to WNT signaling interact with dietary fiber in relation to incidence of type 2 diabetes

  Incident type 2 diabetesa FPG (mmol/L)b FPI (pmol/L)b HbA1C (%)b
  HR (95 % CI) P value Beta (SE) P value Beta (SE) P value Beta (SE) P value
TCF7L2 rs7903146 1.33 (1.25–1.40) 1 × 10−23 0.04 (0.02) 0.03 0.16 (1.05) 0.82 0.02 (0.01) 0.04
TCF7L2 rs12255372 1.24 (1.17–1.31) 9 × 10−14 0.03 (0.02) 0.15 −0.73 (1.07) 0.79 0.02 (0.01) 0.07
HHEX rs1111875 1.06 (1.01–1.12) 0.03 −0.02 (0.02) 0.20 −3.07 (0.99) 0.016 0.01 (0.01) 0.31
HNF1A rs7957197 1.12 (1.05–1.20) 0.001 0.04 (0.02) 0.04 1.11 (1.23) 0.54 0.01 (0.01) 0.30
NOTCH2 rs10923931 0.99 (0.91–1.09) 0.90 0.04 (0.03) 0.19 −0.14 (1.73) 0.69 0.02 (0.02) 0.35
TLE4 rs13292136 1.03 (0.94–1.12) 0.60 −7 × 10−05 (0.03) 1.00 1.71 (1.72) 0.40 0.02 (0.02) 0.30
ZBED3 rs4457053 1.01 (0.96–1.08) 0.64 0.01 (0.02) 0.44 −1.41 (1.14) 0.22 0.02 (0.01) 0.04
PPARG rs1801282 1.08 (1.00–1.16) 0.051 0.03 (0.02) 0.24 1.16 (1.38) 0.42 −0.002 (0.01) 0.88
PPARG rs13081389 1.00 (0.91–1.11) 0.97 0.03 (0.03) 0.35 1.67 (1.79) 0.33 0.01 (0.02) 0.68
  1. HR hazard ratio, FPG fasting plasma glucose, FPI fasting plasma insulin, HbA 1C glycated hemoglobin
  2. aAdjusted for age and sex, N = 26,905
  3. bAdjusted for age and sex; data available only for the MDC-CC, N = 5499