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Table 2 Pathways significantly influenced by maternal protein restriction in the day 13 rat placenta

From: The effect of maternal undernutrition on the rat placental transcriptome: protein restriction up-regulates cholesterol transport

Pathway

P value (log10)

Differentially expressed genes in pathway

Acute-phase signalling

11

C1R, C4A/C4B, Serpin G1, TTr, TF, C1S, ApoA2, Serpin A1, Serpin F2, Fgg, Rbp4

FXR/RXR activation

10.9

C4A/C4B, TTr, ApoB, TF, ApoA2, Serpin A1, ApoC2, Serpoin G2, Mttp, Rbp4

LXR/RXR activation

9.59

C4A/C4B, Ttr, ApoB, TF, ApoA2, ApoC2, Serpin A1, Serpin F, Rbp4

Atherosclerosis signalling

6.72

ApoB, ApoA2, ApocC2, Serpin A1, Pla2g2A, Selpg, Rbp4

Clathrin-mediated endocytosis

5.55

ApoB, RF, ApoA2, ApoC2, Serpin A1, Actg2, Rbp4

IL12 signalling in macrophages

4.08

ApoB, ApoA2, ApoC2, Serpin A1, Rbp4

Coagulation system

3.66

Serpin A1 Serpin F2, Fgg

Nitric oxide and ROS production in macrophages

3.47

ApoB, ApoA2, ApoC2, Serpin A1, Rbp4

  1. The table shows ingenuity canonical pathways with significant enrichment in comparison of control and low protein exposed placentas