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Table 3 Anti-adipogenic miRNAs

From: Role of microRNAs in obesity and obesity-related diseases

miRNA Target/process Reference
let-7 FABP4 and PPARγ signaling pathway. Antiregulates clonal expansion via HMGA2 [74]
miR-15a Delta-like 1 homolog [190]
miR-22 HDAC6 [191]
miR-27a/b MAPK/ERK signaling via PHB, C/EBPβ, PPARγ, and aP2 signaling. Attenuates lipid accumulation [65]
miR-31 C/EBPα signaling. [192]
miR-33b Decrease lipogenesis via early B cell factor 1 (EBF1) targeting C/EBPα and PPARγ signaling [193]
miR-93 Sirt7 and Tbx3 [194]
miR-125a ERRα [195]
miR-130 Inhibition of adipogenesis by inhibiting PPARγ [66]
miR-138 Inhibition of adipocyte differentiation via EID-1. Lipid droplet reduction [196]
miR-145 Preadipocyte differentiation by targeting IRS1 [197]
miR-155 C/EBPβ pathway [198]
mirR-193a/b Adiponectin production in the adipose tissue. Induce myoblast differentiation into brown adipocytes [199]
miR-194 Stimulates osteogenesis and inhibits adipogenesis via COUP-TFII [200]
miR-221 Adiponectin signaling [198]
miR-222 Glucose metabolism. Altered by insulin administration [198]
miR-224 EGR2. Fatty acid metabolism [201]
miR-344 GSK3β, activating the Wnt/β-catenin signaling pathway. Decreases triglyceride accumulation [65]
miR-363 Inhibits adipocyte differentiation by targeting E2F3. Downregulates C/EBPα and PPARγ [73]
miR-365 Brown fat differentiation [202]
miR-369 FABP4. Adipogenic differentiation [187]
miR-448 KLF5. Activation of serotonin receptors 5-HT2AR and 5-HT2CR [203]
miR-709 GSK3ß of Wnt/ß-catenin signaling [204]