Table 3 Anti-adipogenic miRNAs

let-7

FABP4 and PPARγ signaling pathway. Antiregulates clonal expansion via HMGA2

[74]

miR-15a

Delta-like 1 homolog

[190]

miR-22

HDAC6

[191]

miR-27a/b

MAPK/ERK signaling via PHB, C/EBPβ, PPARγ, and aP2 signaling. Attenuates lipid accumulation

[65]

miR-31

C/EBPα signaling.

[192]

miR-33b

Decrease lipogenesis via early B cell factor 1 (EBF1) targeting C/EBPα and PPARγ signaling

[193]

miR-93

Sirt7 and Tbx3

[194]

miR-125a

ERRα

[195]

miR-130

Inhibition of adipogenesis by inhibiting PPARγ

[66]

miR-138

Inhibition of adipocyte differentiation via EID-1. Lipid droplet reduction

[196]

miR-145

Preadipocyte differentiation by targeting IRS1

[197]

miR-155

C/EBPβ pathway

[198]

mirR-193a/b

Adiponectin production in the adipose tissue. Induce myoblast differentiation into brown adipocytes

[199]

miR-194

Stimulates osteogenesis and inhibits adipogenesis via COUP-TFII

[200]

miR-221

Adiponectin signaling

[198]

miR-222

Glucose metabolism. Altered by insulin administration

[198]

miR-224

EGR2. Fatty acid metabolism

[201]

miR-344

GSK3β, activating the Wnt/β-catenin signaling pathway. Decreases triglyceride accumulation

[65]

miR-363

Inhibits adipocyte differentiation by targeting E2F3. Downregulates C/EBPα and PPARγ

[73]

miR-365

Brown fat differentiation

[202]

miR-369

FABP4. Adipogenic differentiation

[187]

miR-448

KLF5. Activation of serotonin receptors 5-HT2AR and 5-HT2CR

[203]

miR-709

GSK3ß of Wnt/ß-catenin signaling

[204]