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Table 1 Positively selected SNPs within cofactor transporter genes

From: Ancestors’ dietary patterns and environments could drive positive selection in genes involved in micronutrient metabolism—the case of cofactor transporters

Genes

Official gene name

Cofactors

Tissue enrichmenta

Chr

PC

SNPs

CACNA1A

Calcium voltage-gated channel subunit alpha1 A

Ca

Tissue enhanced: cerebral cortex; stomach

19

PC3

rs7254771 (0.03)

CACNB4

Calcium voltage-gated channel auxiliary subunit beta 4

Ca

Tissue enhanced: cerebral cortex

2

PC5

rs16830593 (0.007); rs11902858 (0.02)

HPX

Hemopexin

Fe

Tissue enriched: liver

11

PC5

rs16913549 (0.01)

KCNB2

Potassium voltage-gated channel subfamily B member 2

K

Tissue enhanced: cerebral cortex; spleen

8

PC5

rs7833062 (0.04); rs6996335 (0.02)

KCNH5

Potassium voltage-gated channel subfamily H member 5

K

Tissue enhanced: adrenal gland; cerebral cortex

14

PC5

rs8019319 (0.007)

KCNH7

Potassium voltage-gated channel subfamily H member 7

K

Tissue enriched: cerebral cortex

2

PC3; PC5

rs6753132 (0.05); rs6708255 (0.007); rs7588788 (0.07)

KCNK13

Potassium two pore domain channel subfamily K member 13

K

Tissue enhanced: testis

14

PC3

rs3861656 (0.025); rs4462529 (0.025); rs17223880 (0.025)

LRP2

LDL receptor related protein 2

D3

Group enriched: kidney; placenta; thyroid gland

2

PC5

rs16856593 (0.004)

RYR2

Ryanodine receptor 2

Ca

Tissue enriched: heart muscle

1

PC5

rs12087761 (0.011)

SLC11A2

Solute carrier family 11 member 2

Co

Expressed in all

12

PC5

rs12312876 (2.70E-08)

SLC24A3

Solute carrier family 24 member 3

K,Ca

Mixed

20

PC5

rs10485588 (0.04); rs16980447 (0.03); rs6112335 (0.02); rs6035421 (0.02)

SLC25A26

Solute carrier family 25 member 26

SAM

Expressed in all

3

PC3

rs17044224 (0.03); rs1471476 (0.03);

SLCO1A2

Solute carrier organic anion transporter family member 1A2

GSH

Group enriched: cerebral cortex; liver; lung; salivary gland

12

PC5

rs2199685 (0.03)

TRPM4

Transient receptor potential cation channel subfamily M member 4

Ca

Mixed

19

PC5

rs8104571 (0.0008)

  1. Ca calcium, Co cobalt, Chr chromosome, D3 vitamin D3, Fe iron, K potassium, GSH Glutathione, PC principal component, SAM S-Adenosylmethionine
  2. aTissue enrichment category from Human Protein Atlas among the following categories: (i) Tissue enriched: mRNA levels in one tissue at least five times higher than all other tissues, (ii) Group enriched: mRNA levels of a group of 2 to 7 tissues at least five times those of all other tissues, (iii) Tissue enhanced: mRNA levels in a particular tissue at least five times the average level in all tissues, (iv) Expressed in all: mRNA detected in all tissues, (v) Mixed: detected in fewer than 32 tissues but not elevated in any tissue, or (vi) Not detected. Tissue(s) where protein is enriched in cases of Tissue enriched, enhanced or group enhanced is listed
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Genes & Nutrition

ISSN: 1865-3499

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