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Table 1 Positively selected SNPs within cofactor transporter genes

From: Ancestors’ dietary patterns and environments could drive positive selection in genes involved in micronutrient metabolism—the case of cofactor transporters

Genes Official gene name Cofactors Tissue enrichmenta Chr PC SNPs
CACNA1A Calcium voltage-gated channel subunit alpha1 A Ca Tissue enhanced: cerebral cortex; stomach 19 PC3 rs7254771 (0.03)
CACNB4 Calcium voltage-gated channel auxiliary subunit beta 4 Ca Tissue enhanced: cerebral cortex 2 PC5 rs16830593 (0.007); rs11902858 (0.02)
HPX Hemopexin Fe Tissue enriched: liver 11 PC5 rs16913549 (0.01)
KCNB2 Potassium voltage-gated channel subfamily B member 2 K Tissue enhanced: cerebral cortex; spleen 8 PC5 rs7833062 (0.04); rs6996335 (0.02)
KCNH5 Potassium voltage-gated channel subfamily H member 5 K Tissue enhanced: adrenal gland; cerebral cortex 14 PC5 rs8019319 (0.007)
KCNH7 Potassium voltage-gated channel subfamily H member 7 K Tissue enriched: cerebral cortex 2 PC3; PC5 rs6753132 (0.05); rs6708255 (0.007); rs7588788 (0.07)
KCNK13 Potassium two pore domain channel subfamily K member 13 K Tissue enhanced: testis 14 PC3 rs3861656 (0.025); rs4462529 (0.025); rs17223880 (0.025)
LRP2 LDL receptor related protein 2 D3 Group enriched: kidney; placenta; thyroid gland 2 PC5 rs16856593 (0.004)
RYR2 Ryanodine receptor 2 Ca Tissue enriched: heart muscle 1 PC5 rs12087761 (0.011)
SLC11A2 Solute carrier family 11 member 2 Co Expressed in all 12 PC5 rs12312876 (2.70E-08)
SLC24A3 Solute carrier family 24 member 3 K,Ca Mixed 20 PC5 rs10485588 (0.04); rs16980447 (0.03); rs6112335 (0.02); rs6035421 (0.02)
SLC25A26 Solute carrier family 25 member 26 SAM Expressed in all 3 PC3 rs17044224 (0.03); rs1471476 (0.03);
SLCO1A2 Solute carrier organic anion transporter family member 1A2 GSH Group enriched: cerebral cortex; liver; lung; salivary gland 12 PC5 rs2199685 (0.03)
TRPM4 Transient receptor potential cation channel subfamily M member 4 Ca Mixed 19 PC5 rs8104571 (0.0008)
  1. Ca calcium, Co cobalt, Chr chromosome, D3 vitamin D3, Fe iron, K potassium, GSH Glutathione, PC principal component, SAM S-Adenosylmethionine
  2. aTissue enrichment category from Human Protein Atlas among the following categories: (i) Tissue enriched: mRNA levels in one tissue at least five times higher than all other tissues, (ii) Group enriched: mRNA levels of a group of 2 to 7 tissues at least five times those of all other tissues, (iii) Tissue enhanced: mRNA levels in a particular tissue at least five times the average level in all tissues, (iv) Expressed in all: mRNA detected in all tissues, (v) Mixed: detected in fewer than 32 tissues but not elevated in any tissue, or (vi) Not detected. Tissue(s) where protein is enriched in cases of Tissue enriched, enhanced or group enhanced is listed