Fig. 3

Diagram representing the genes associated with vitamin B12 status. The diagram shows the proteins involved in the metabolism of vitamin B12 from the extracellular space to being internalized within the cell. Genes identified to harbour variants regulating serum levels of B12 are surrounded by dashed lines. Ado-B12 adenosyl-cobalamin; ABDC4 ATP-binding cassette, sub-family D (ALD), member 4; CD320 CD320 molecule; CLYBL citrate lyase beta like; DNMT2 DNA methyltransferase 2 gene; LMBD1 LMBR1 domain containing 1; LMBRD1 LMBR1 domain containing 1; MMAA methylmalonic aciduria (cobalamin deficiency) CblA type; MMAB methylmalonic aciduria (cobalamin deficiency) CblB type; MMACHC methylmalonic aciduria and homocystinuria, cblC type; MMADHC methylmalonic aciduria (cobalamin deficiency) CblD type, with homocystinuria; MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific); MTHFR 5-methyl-tetrahydrafolate reductase; MTR 5-methyltetrahydrofolate-homocysteine methyltransferase; MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase; MUT methylmalonyl CoA mutase; PRELID2 PRELI domain containing 2; THF tetrahydrofolate; 5,10-Methyl THF 5,10-methyl-tetrahydrofolate