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Table 5 Selected differentially expressed genes (DEG, with the highest FC) and biological processes which they were involved in

From: Effect of β-hydroxy-β-methylbutyrate on miRNA expression in differentiating equine satellite cells exposed to hydrogen peroxide

No. Gene symbol Regulation Fold change Description Accession number Related processes
1 cxcl2 Up 76.31 Equus caballus chemokine (C–X–C motif) ligand 2 (CXCL2) [ENSECAT00000010991] Expressed in regenerating muscle
2 cxcl10 Up 52.29 Equus caballus chemokine (C–X–C motif) ligand 10 [NM_001114940] Acute inflammation
Acute skeletal muscle injury
3 il-6 Up 20.00 Equus caballus interleukin 6 (interferon, beta 2) (IL6) [NM_001082496] Mediates the generation and elimination of ROS, stimulates SCs proliferation and hypertrophy
4 ccl2 Up 19.41 Equus caballus chemokine (C–C motif) ligand 2 [NM_001081931] Acute inflammation
Acute skeletal muscle injury
5 tlr3 Up 17.95 Equus caballus Toll-like receptor 3 (TLR3) [NM_001081798] Oxidative stress, enhances cell viability
6 saa1 Up 16.80 Equus caballus serum amyloid A1 [NM_001163892] Acute phase response in skeletal muscle
7 ccl5 Up 11.74 Equus caballus chemokine (C–C motif) ligand 5 (CCL5) [NM_001081863] MAPK cascade, chronic inflammatory response
8 ccl11 Up 11.66 Equus caballus chemokine (C–C motif) ligand 11 (CCL11) [NM_001081871] Smooth muscle cell migration, chronic inflammatory response
9 sod2 Up 9.38 Equus caballus superoxide dismutase 2 [NM_001082517] Oxidative stress
10 xaf1 Up 7.80 XIAP-associated factor 1 [ENSECAT00000026936] Apoptosis
11 parp14 Up 7.20 Poly(ADP-ribose) polymerase family member 14 [ENSECAT00000026964] Muscle metabolism
12 gsdmd Up 6.31 Gasdermin d [ENSECAT00000015748] Necrosis in inflammation, cell proliferation, induce apoptosis
13 fgf7 Up 5.83 Equus caballus fibroblast growth factor 7 (FGF7) [NM_001163883] Participate in the proliferation of activated satellite cells via the Ras–Raf–MEK–ERK signaling pathway
14 jak2 Up 5.14 Janus kinase 2 [ENSECAT00000010434] Response to injury
15 cd40 Up 5.05 Equus caballus CD40 molecule, TNF receptor superfamily member 5 (CD40) [NM_001081902] Humoral and cell-mediated immune responses, effective immune activation
16 casp7 Up 4.93 Caspase 7 [JL623025] Muscle cell proliferation/survival
17 psmb9 Up 4.81 Proteasome (prosome, macropain) subunit, beta type, 9 [ENSECAT00000017937] Muscle cell differentiation
18 aox1 Up 4.10 Equus caballus aldehyde oxidase 1 [NM_001287267] Muscle cell differentiation