Table 5 Selected differentially expressed genes (DEG, with the highest FC) and biological processes which they were involved in
No. | Gene symbol | Regulation | Fold change | Description | Accession number | Related processes |
|---|---|---|---|---|---|---|
1 | cxcl2 | Up | 76.31 | Equus caballus chemokine (C–X–C motif) ligand 2 (CXCL2) | [ENSECAT00000010991] | Expressed in regenerating muscle |
2 | cxcl10 | Up | 52.29 | Equus caballus chemokine (C–X–C motif) ligand 10 | [NM_001114940] | Acute inflammation Acute skeletal muscle injury |
3 | il-6 | Up | 20.00 | Equus caballus interleukin 6 (interferon, beta 2) (IL6) | [NM_001082496] | Mediates the generation and elimination of ROS, stimulates SCs proliferation and hypertrophy |
4 | ccl2 | Up | 19.41 | Equus caballus chemokine (C–C motif) ligand 2 | [NM_001081931] | Acute inflammation Acute skeletal muscle injury |
5 | tlr3 | Up | 17.95 | Equus caballus Toll-like receptor 3 (TLR3) | [NM_001081798] | Oxidative stress, enhances cell viability |
6 | saa1 | Up | 16.80 | Equus caballus serum amyloid A1 | [NM_001163892] | Acute phase response in skeletal muscle |
7 | ccl5 | Up | 11.74 | Equus caballus chemokine (C–C motif) ligand 5 (CCL5) | [NM_001081863] | MAPK cascade, chronic inflammatory response |
8 | ccl11 | Up | 11.66 | Equus caballus chemokine (C–C motif) ligand 11 (CCL11) | [NM_001081871] | Smooth muscle cell migration, chronic inflammatory response |
9 | sod2 | Up | 9.38 | Equus caballus superoxide dismutase 2 | [NM_001082517] | Oxidative stress |
10 | xaf1 | Up | 7.80 | XIAP-associated factor 1 | [ENSECAT00000026936] | Apoptosis |
11 | parp14 | Up | 7.20 | Poly(ADP-ribose) polymerase family member 14 | [ENSECAT00000026964] | Muscle metabolism |
12 | gsdmd | Up | 6.31 | Gasdermin d | [ENSECAT00000015748] | Necrosis in inflammation, cell proliferation, induce apoptosis |
13 | fgf7 | Up | 5.83 | Equus caballus fibroblast growth factor 7 (FGF7) | [NM_001163883] | Participate in the proliferation of activated satellite cells via the Ras–Raf–MEK–ERK signaling pathway |
14 | jak2 | Up | 5.14 | Janus kinase 2 | [ENSECAT00000010434] | Response to injury |
15 | cd40 | Up | 5.05 | Equus caballus CD40 molecule, TNF receptor superfamily member 5 (CD40) | [NM_001081902] | Humoral and cell-mediated immune responses, effective immune activation |
16 | casp7 | Up | 4.93 | Caspase 7 | [JL623025] | Muscle cell proliferation/survival |
17 | psmb9 | Up | 4.81 | Proteasome (prosome, macropain) subunit, beta type, 9 | [ENSECAT00000017937] | Muscle cell differentiation |
18 | aox1 | Up | 4.10 | Equus caballus aldehyde oxidase 1 | [NM_001287267] | Muscle cell differentiation |