Dietary and genetic risk scores and incidence of type 2 diabetes

Genes & Nutrition

Table 4 Hazard ratios of incident type 2 diabetes according to a diet risk score based on intakes of processed meat, sugar-sweetened beverages (SSB), whole grain and coffee in strata of a weighted genetic risk score among 15,380 women and 9689 men from the Malmö Diet and Cancer Study

	All				Women				Men
Diet risk score level/diet tertile	Tertile of genetic risk score				Tertile of genetic risk score				Tertile of genetic risk score
Diet risk score level/diet tertile	1	2	3		1	2	3		1	2	3
Diet risk score
Low	1.00	1.00	1.00		1.00	1.00	1.00		1.00	1.00	1.00
Medium	1.23 1.03, 1.46	1.17 1.01, 1.36	1.20 1.04, 1.37		1.48 1.16, 1.90	1.23 1.00, 1.51	1.32 1.09, 1.59		1.02 0.80, 1.31	1.12 0.89, 1.39	1.11 0.91, 1.36
High	1.42 1.15, 1.76	1.42 1.18, 1.71	1.40 1.18, 1.65		1.68 1.24, 2.27	1.45 1.11, 1.89	1.38 1.09, 1.76		1.21 0.90, 1.63	1.40 1.07, 1.83	1.40 1.10, 1.78
P_trend*	0.001	3 × 10⁻⁴	8 × 10⁻⁵		0.001	0.006	0.005		0.20	0.01	0.005
P_interaction*^,†				0.83 (0.94)				0.40 (0.67)				0.60 (0.73)

*Age-stratified model, adjusted for sex, diet method version, season, total energy intake, BMI, leisure time physical activity, alcohol intake, smoking and education
^†P for interaction treating tertiles as continuous variables and, in brackets, P for interaction between continuous variables of the GRS and the DRS

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