Plasma fatty acid levels and gene expression related to lipid metabolism in peripheral blood mononuclear cells: a cross-sectional study in healthy subjects

Table 3 Differentially expressed genes between subjects in the highest and lowest plasma n-6 tertile

Gene	Highest tertile (n 18)	Lowest tertile (n 18)	Mean difference	P
STAB1*	8.66 ± 0.30	8.30 ± 0.47	0.36	0.011
SORL1	10.25 ± 0.27	10.06 ± 0.27	0.19	0.039
KLHL8*	9.13 ± 0.25	8.94 ± 0.19	0.18	0.020
DAGLB	9.21 ± 0.30	9.03 ± 0.19	0.18	0.040
TOM1*	9.78 ± 0.24	9.62 ± 0.20	0.16	0.037
PXN*	8.14 ± 0.19	8.00 ± 0.18	0.14	0.030
HMGCR*	8.85 ± 0.14	8.76 ± 0.11	0.09	0.036
KAT5	7.45 ± 0.09	7.39 ± 0.09	0.06	0.047
LRP5	6.79 ± 0.09	6.87 ± 0.09	− 0.08	0.013
LACTB	7.15 ± 0.12	7.24 ± 0.12	− 0.09	0.027
SELS	9.66 ± 0.12	9.83 ± 0.27	− 0.18	0.020
XBP1	10.63 ± 0.23	10.85 ± 0.37	− 0.22	0.042
EPHX2*	8.18 ± 0.32	8.40 ± 0.30	− 0.22	0.043
CAV1*	6.88 ± 0.11	7.13 ± 0.32	− 0.25	0.005
COBLL1	7.98 ± 0.23	8.28 ± 0.49	− 0.30	0.028

Expression of genes is given as mRNA level. Values are presented as mean ± SD and are log2 transformed. Differences between tertiles were analyzed using the independent samples t test. P values < 0.05 were considered significant
*Genes differentially expressed between subjects in the highest and lowest n-6 tertile and between subjects in the highest and lowest SFA to PUFA ratio tertile. The genes presented in italics are expressed by more than one probe (shown in Additional file 2: Table S2). The probe with lowest p-value is shown in Table 3

ISSN: 1865-3499