Plasma fatty acid levels and gene expression related to lipid metabolism in peripheral blood mononuclear cells: a cross-sectional study in healthy subjects

Table 5 Differentially expressed genes between subjects in the highest and lowest plasma SFA to PUFA ratio tertile

Gene	Highest tertile (n 18)	Lowest tertile (n 18)	Mean difference	P
EPHX2*	8.41 ± 0.33	8.18 ± 0.31	0.23	0.036
FAM117B	8.58 ± 0.33	8.36 ± 0.09	0.22	0.012
CAV1*	7.09 ± 0.27	6.87 ± 0.23	0.22	0.014
SEC24A	7.72 ± 0.26	7.56 ± 0.17	0.16	0.038
UBE2L3**	7.24 ± 0.18	7.09 ± 0.13	0.15	0.010
ARV1	8.07 ± 0.16	7.95 ± 0.11	0.12	0.011
NFKB1	11.09 ± 0.10	11.00 ± 0.15	0.09	0.037
SNX13	7.49 ± 0.15	7.40 ± 0.10	0.09	0.045
INSIG2	8.14 ± 0.09	8.07 ± 0.07	0.06	0.025
TMEM188	7.01 ± 0.07	6.95 ± 0.09	0.06	0.034
ERLIN2	6.99 ± 0.06	6.93 ± 0.06	0.05	0.034
CPS1	6.84 ± 0.07	6.79 ± 0.07	0.05	0.033
TOM1*	7.04 ± 0.08	7.13 ± 0.10	− 0.09	0.006
POR	7.75 ± 0.14	7.85 ± 0.11	− 0.10	0.037
GSK3B	8.22 ± 0.15	8.32 ± 0.13	− 0.10	0.021
HMGCR*	8.76 ± 0.19	8.88 ± 0.13	− 0.12	0.015
RBM5	10.81 ± 0.12	10.93 ± 0.15	− 0.12	0.033
ERGIC3	10.54 ± 0.18	10.67 ± 0.13	− 0.12	0.031
PXN*	8.00 ± 0.14	8.13 ± 0.15	− 0.13	0.014
SCARB1	7.49 ± 0.23	7.62 ± 0.12	− 0.14	0.025
APOBR	8.11 ± 0.18	8.25 ± 0.17	− 0.14	0.038
KLHL8*	8.96 ± 0.21	9.13 ± 0.25	− 0.17	0.042
ABCA2	7.41 ± 0.25	7.61 ± 0.30	− 0.20	0.042
PNPLA2	8.28 ± 0.28	8.48 ± 0.30	− 0.20	0.050
STAB1*	8.31 ± 0.50	8.67 ± 0.38	− 0.35	0.023

Expression of genes is given as mRNA level. Values are presented as mean ± SD and are log2 transformed. Differences between tertiles were analyzed using the independent samples t test. P values < 0.05 were considered significant
*Genes differentially expressed between subjects in the highest and lowest n-6 tertile and between subjects in the highest and lowest SFA to PUFA ratio tertile
**Genes differentially expressed between subjects in the highest and lowest n-3 tertile and between subjects in the highest and lowest SFA to PUFA ratio tertile. The genes presented in italics are expressed by more than one probe (shown in Additional file 4: Table S4). The probe with lowest p-value is shown in Table 5

ISSN: 1865-3499