Genetic polymorphism in selenoprotein P modifies the response to selenium-rich foods on blood levels of selenium and selenoprotein P in a randomized dietary intervention study in Danes

Kopp, Tine Iskov; Outzen, Malene; Olsen, Anja; Vogel, Ulla; Ravn-Haren, Gitte

doi:10.1186/s12263-018-0608-4

Table 3 Association between mean concentrations of erythrocyte GPX enzyme activity, whole blood selenium, and selenoprotein P in relation to the studied polymorphisms, and within-subject effects between genotype and time in the intervention group

From: Genetic polymorphism in selenoprotein P modifies the response to selenium-rich foods on blood levels of selenium and selenoprotein P in a randomized dietary intervention study in Danes

Erythrocyte GPX enzyme activity, log (U/g Hb)
SNP	n	Baseline		13 weeks^c		26 weeks^c		P value for interaction between genotype and time
SNP		Difference between means (95% CI)	P value	Difference between means (95% CI)	P value	Difference between means (95% CI)	P value	P value for interaction between genotype and time
GPX1/rs1050450
CC	20	− 0.224 (− 0.442, − 0.00638)	0.044	0.0299 (− 0.00981, 0.0696)	0.14	− 0.00585 (− 0.06278, 0.0511)	0.84	0.085
CT + TT	21	− 0.224 (− 0.442, − 0.00638)	0.044	0.0299 (− 0.00981, 0.0696)	0.14	− 0.00585 (− 0.06278, 0.0511)	0.84	0.085
GPX4/rs713041
CC	15	0.129 (− 0.105, 0.364)	0.27	− 0.00532 (− 0.0462, 0.0355)	0.79	− 0.0143 (− 0.0711, 0.0424)	0.61	0.79
CT + TT	26	0.129 (− 0.105, 0.364)	0.27	− 0.00532 (− 0.0462, 0.0355)	0.79	− 0.0143 (− 0.0711, 0.0424)	0.61	0.79
SELENOP/rs3877899
CC	25	− 0.0228 (− 0.258, 0.212)	0.85	− 0.00617 (− 0.0459, 0.0335)	0.75	0.0145 (− 0.0407, 0.0697)	0.60	0.70
CT + TT	16	− 0.0228 (− 0.258, 0.212)	0.85	− 0.00617 (− 0.0459, 0.0335)	0.75	0.0145 (− 0.0407, 0.0697)	0.60	0.70
SELENOP/rs7579
GG	22	− 0.0278 (− 0.258, 0.202)	0.81	− 0.0134 (− 0.0521, 0.0252)	0.49	− 0.0143 (− 0.0683, 0.0397)	0.60	0.81
GA + AA	19	− 0.0278 (− 0.258, 0.202)	0.81	− 0.0134 (− 0.0521, 0.0252)	0.49	− 0.0143 (− 0.0683, 0.0397)	0.60	0.81
Whole blood selenium, ng/mL
SNP	n*	Baseline		13 weeks^d		26 weeks^d		P value for interaction between genotype and time
SNP		Difference between means (95% CI)	P value	Difference between means (95% CI)	P value	Difference between means (95% CI)	P value	P value for interaction between genotype and time
GPX1/rs1050450
CC	23	3.20 (− 5.46, 11.9)	0.46	− 0.989 (−7.89, 5.91)	0.77	− 1.24 (− 8.11, 5.63)	0.72	0.83
CT + TT	26	3.20 (− 5.46, 11.9)	0.46	− 0.989 (−7.89, 5.91)	0.77	− 1.24 (− 8.11, 5.63)	0.72	0.83
GPX4/rs713041
CC	16	4.85 (− 4.32, 14.0)	0.29	− 2.76 (− 9.91, 4.38)	0.44	− 1.77 (− 8.93, 5.39)	0.62	0.54
CT + TT	33	4.85 (− 4.32, 14.0)	0.29	− 2.76 (− 9.91, 4.38)	0.44	− 1.77 (− 8.93, 5.39)	0.62	0.54
SELENOP/rs3877899
CC	30	0.989 (− 7.93, 9.91)	0.82	0.675 (− 6.37, 7.72)	0.85	− 5.76 (− 12.5, 1.01)	0.093	0.13
CT + TT	19	0.989 (− 7.93, 9.91)	0.82	0.675 (− 6.37, 7.72)	0.85	− 5.76 (− 12.5, 1.01)	0.093	0.13
SELENOP/rs7579
GG	24	4.44 (− 4.16, 13.0)	0.30	− 4.04 (− 10.9, 2.80)	0.24	1.60 (− 5.32, 8.53)	0.64	0.23
GA + AA	25	4.44 (− 4.16, 13.0)	0.30	− 4.04 (− 10.9, 2.80)	0.24	1.60 (− 5.32, 8.53)	0.64	0.23
Selenoprotein P, ng/mL
SNP	n ^b	Baseline		13 weeks^e		26 weeks^e		P value for interaction between genotype and time
SNP		Difference between means (95% CI)	P value	Difference between means (95% CI)	P value	Difference between means (95% CI)	P value	P value for interaction between genotype and time
GPX1/rs1050450
CC	21	4.17 (− 0.51, 8.85)	0.080	− 1.17 (− 5.38, 3.04)	0.58	− 2.56 (− 6.60, 1.47)	0.21	0.071
CT + TT	25	4.17 (− 0.51, 8.85)	0.080	− 1.17 (− 5.38, 3.04)	0.58	− 2.56 (− 6.60, 1.47)	0.21	0.071
GPX4/rs713041
CC	16	3.49 (− 1.47, 8.45)	0.16	0.801 (− 3.41, 5.01)	0.70	− 1.17 (− 5.32, 2.97)	0.57	0.48
CT + TT	30	3.49 (− 1.47, 8.45)	0.16	0.801 (− 3.41, 5.01)	0.70	− 1.17 (− 5.32, 2.97)	0.57	0.48
SELENOP/rs3877899
CC	28	− 2.33 (− 7.23, 2.57)	0.34	− 2.43 (− 6.53, 1.67)	0.24	− 4.68 (− 8.49, − 0.871)	0.018	0.33
CT + TT	18	− 2.33 (− 7.23, 2.57)	0.34	− 2.43 (− 6.53, 1.67)	0.24	− 4.68 (− 8.49, − 0.871)	0.018	0.33
SELENOP/rs7579
GG	23	2.16 (− 2.63, 6.94)	0.37	1.72 (− 2.35, 5.79)	0.40	− 0.630 (− 4.66, 3.40)	0.75	0.79
GA + AA	23	2.16 (− 2.63, 6.94)	0.37	1.72 (− 2.35, 5.79)	0.40	− 0.630 (− 4.66, 3.40)	0.75	0.79

^a13 and 26 weeks’ measurements only included 41 participants due to discontinuation of intervention
^b13 and 26 weeks’ measurements only included 38 participants due to discontinuation of intervention
^cAdjusted for baseline levels of erythrocyte GPX enzyme activity
^dAdjusted for baseline levels of whole blood selenium
^eAdjusted for baseline levels of selenoprotein P

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