Skip to main content

Table 2 Evaluation of the validity of the identified candidate biomarkers of food intake for liquorice

From: Biomarkers of food intake for cocoa and liquorice (products): a systematic review

Metabolite

Bio fluid

Q1

Q2

Q3

Q4

Q5

Q6

Q7

Q8

Q9

Sum

References

Candidate liquorice biomarkers of food intake

18-glycyrrhetic acid

Plasma

U

U

Y

U

Y

N

U

Y

N

3

[50, 51, 55]

Serum

U

U

Y

U

Y

N

U

Y

N

3

[54]

Blood

U

U

Y

U

N

N

U

Y

N

2

[53]

Urine

U

Y

Y

U

Y

N

U

Y

N

4

[51,52,53]

3β-monoglucuronyl-18β-glycyrrhetinic acid

Urine

U

U

N

U

Y

N

U

Y

N

2

[19]

Glabridin

Plasma

U

U

U

U

N

N

U

N

N

0

[56]

  1. Y yes, N no, U unknown
  2. Q1: Is the marker compound plausible as a specific BFI for the food or food group (chemical/biological plausibility)?
  3. Q2: Is there a dose-response relationship at relevant intake levels of the targeted food (quantitative aspect)?
  4. Q3: Is the single-meal time-response relationship described adequately to make a wise choice of sample type and time window (single-dose kinetics)?
  5. Q4: Is the biomarker kinetics for repeated intakes of the food/food group described adequately providing the frequency of sampling needed to assess habitual intake (e.g. cumulative aspects)?
  6. Q5: Has the marker been shown to be robust after intake of complex meals reflecting dietary habits of the targeted population (robustness)?
  7. Q6: Has the marker been shown to compare well with other markers or questionnaire data for the same food/food group (reliability)?
  8. Q7: Is the marker chemically and biologically stable during bio specimen collection and storage, making measurements reliable and feasible?
  9. Q8: Are analytical variability (CV%), accuracy, sensitivity and specificity known as adequate for at least one reported analytical method?
  10. Q9: Has the analysis been successfully reproduced in another laboratory (reproducibility)?
Back to article page

Genes & Nutrition

ISSN: 1865-3499

Contact us