Biomarkers of food intake for nuts and vegetable oils: an extensive literature search

Garcia-Aloy, Mar; Hulshof, Paul J. M.; Estruel-Amades, Sheila; Osté, Maryse C. J.; Lankinen, Maria; Geleijnse, Johanna M.; de Goede, Janette; Ulaszewska, Marynka; Mattivi, Fulvio; Bakker, Stephan J. L.; Schwab, Ursula; Andres-Lacueva, Cristina

doi:10.1186/s12263-019-0628-8

Genes & Nutrition

Table 3 Studies reporting associations between consumption and potential candidate food intake biomarkers for vegetable oils

From: Biomarkers of food intake for nuts and vegetable oils: an extensive literature search

Dietary factor [reference]	Study design	Number of subjects	Analytical method	Sample type	Discriminating metabolites/candidate biomarkers
Olive oil [127]	Sustained intervention	11	GC-FID	Erythrocytes	Oleic acid
Olive oil [128]	Sustained intervention	12	GC-FID	Plasma	Oleic acid
Olive oil^a [129]	Sustained intervention	30	GC-FID	Plasma	Oleic acid
Olive oil [130]	Sustained intervention	21	GC-FID	Plasma/platelets	Oleic acid
Olive oil [131]	Sustained intervention	16	GC-FID	Erythrocytes	Oleic acid
Olive oil	Sustained intervention	30	GC-FID	Plasma/PBMC	Oleic acid
Olive oil, extra virgin [133]	Acute study	10	GC	Plasma—TAG	Oleic acid
Olive oil, pomace and refined [134]	Acute study	10	GC	Serum—TRL	Oleic acid
Olive oil, virgin^a [135]	Acute study	11	UPLC-MS; GC-MS	Urine	Hydroxytyrosol
Olive oil, different phenolic content^a [136]	Acute study	12	GC-MS	Urine	Hydroxytyrosol, 3-O-methy-hydroxytyrosol
Olive oil, enriched or virgin^a [137]	Acute study	13	UPLC-MS/MS	Plasma	Hydroxytyrosol sulfate
Olive oil, virgin [138]	Acute study	13	UPLC-MS/MS	Plasma	Hydroxytyrosol sulfate
Olive oil, high phenolic content [139]	Acute study	12	UPLC-MS/MS	Plasma	Hydroxytyrosol sulfate, hydroxytyrosol acetate sulfate
Olive oil, virgin, moderate and high phenolic content [140]	Acute study	13	UPLC-MS/MS	Plasma	Hydroxytyrosol sulfate, hydroxytyrosol acetate sulfate
Olive oil, extra virgin [141]	Sustained intervention	10	GC-FID	Plasma and cells	Oleic acid
Olive oil, extra virgin [142]	Sustained intervention	424	GC	Plasma	Oleic acid
Olive oil, different phenolic^a compound content [143]	Sustained intervention	30	GC-MS	Urine	Hydroxytyrosol
Olive oil, different phenol content^a [144]	Sustained intervention	200	GC-MS	Urine	Hydroxytyrosol
Olive oil, high-phenol vs low-phenol extra virgin^a [145]	Sustained intervention	10	GC-MS	Urine	Hydroxytyrosol
Olive oils, different phenolic content^a [146]	Sustained intervention	30	HPLC	Urine	Hydroxytyrosol
Olive oil, different phenolic content^a [147]	Sustained intervention	38	GC-MS	Urine	Hydroxytyrosol
Olive oil, refined, common and virgin^a [148]	Sustained intervention	33	HPLC	Urine	Hydroxytyrosol
Olive oil, extra virgin^a [149]	Sustained intervention	20	HPLC-MS	Plasma	Hydroxytyrosol
Olive oil, extra virgin [80]	Sustained intervention	750	GC-MS	Urine	Hydroxytyrosol
Olive oil, different phenolic compound content^a [150]	Sustained intervention	28	GC-MS	Urine	Hydroxytyrosol, O-methylhydroxytyrosol
Olive oil, with different phenolic contents^a [151]	Sustained intervention	182	GC-MS/MS	Urine	Hydroxytyrosol, 3-O-methylhydroxytyrosol
Olive oil, virgin and refined^a [152]	Sustained intervention	36	HPLC-MS/MS	Plasma-LDL	Hydroxytyrosol sulfate
Olive oil, virgin, enriched [153]	Sustained intervention	33	UHPLC-MS/MS	Urine	Hydroxytyrosol sulfate
Olive oil, high polyphenol content^a [154]	Sustained intervention	51	UHPLC-MS/MS	Plasma-HDL	Hydroxytyrosol sulfate
Olive oil, virgin, high phenolic^a [155]	Sustained intervention	5	UPLC-MS/MS	Urine	Hydroxytyrosol sulfate, hydroxytyrosol acetate sulfate
Olive oil, virgin, enriched [156]	Sustained intervention	33	UPLC-MS/MS	Plasma/urine	Hydroxytyrosol sulfate, hydroxytyrosol acetate sulfate
Olive oil, virgin (OO); rapeseed oil (RO); sunflower oil (SO) [157]	Sustained intervention	18	GC-FID	Plasma	Oleic acid (OO, RO), linoleic acid (SO, RO)
Olive oil (OO), canola oil (CO) ^a [158]	Sustained intervention	14	GC-FID	Plasma	Oleic acid (OO, α-Linolenic acid (CO)
Flaxseed oil [159]	Sustained intervention	16	GC-FID	Plasma/PBMC	α-Linolenic acid
Flaxseed oil [160]	Sustained intervention	30	GC-FID	Plasma	α-Linolenic acid
Flaxseed oil [161]	Sustained intervention	46	GC-FID	Platelets	α-Linolenic acid
Flaxseed oil [162]	Sustained intervention	28	GC-FID	Plasma	α-Linolenic acid
Flaxseed oil [163]	Sustained intervention	17	GC-FID	Plasma/platelets	α-Linolenic acid
Flaxseed oil [164]	Sustained intervention	20	GC	Plasma/erythrocytes	α-Linolenic acid
Flaxseed oil [165]	Sustained intervention	51	GC	Erythrocytes	α-Linolenic acid
Flaxseed oil [166]	Sustained intervention	62	GLC	Erythrocytes	α-Linolenic acid
Flaxseed oil [167]	Sustained intervention	86	GC	Plasma	α-Linolenic acid
Flaxseed oil [168]	Sustained intervention	34	GC	Plasma	α-Linolenic acid
Flaxseed oil [169]	Sustained intervention	98	GC	Erythrocytes	α-Linolenic acid
Flaxseed oil [170]	Sustained intervention	26	GC-FID	Plasma	α-Linolenic acid
Flaxseed oil [171]	Sustained intervention	37	GC	Erythrocytes	α-Linolenic acid
Flaxseed oil [172]	Sustained intervention	15	GC-FID	Serum	α-Linolenic acid
Flaxseed oil (FO); sunflower oil (SO) [173]	Sustained intervention	10	GC-FID	Platelets	α-Linolenic acid (FO); linoleic acid (SO)
Rapeseed oil [177]	Sustained intervention	40	GC-FID	Plasma	α-Linolenic acid
Canola oil^a [174]	Sustained intervention	14	GC-FID	Breastmilk	α-Linolenic acid
Canola oil [175]	Sustained intervention	130	GC-FID	Plasma	α-Linolenic acid
Canola oil [176]	Sustained intervention	130	GC-FID	Plasma	α-Linolenic acid
Canola oil (CO); sunflower oil (SO) ^a [178]	Sustained intervention	8	GC-FID	Plasma	α-Linolenic acid (CO); linoleic acid (SO)
Canola oil (CO); sunflower oil (SO) [179]	Sustained intervention	8	GC-FID	Platelets	α-Linolenic acid (CO); linoleic acid (SO)
Sunflower oil [180]	Sustained intervention	37	GC	Plasma-CE/ASAT	Linoleic acid

ASAT abdominal subcutaneous adipose tissue, CE cholesterol esters, FID flame ionization detector, GC gas chromatography, GLC gas-liquid chromatography, HPLC high-performance liquid chromatography, MS mass spectrometry, MS/MS tandem mass spectrometry, PBMC peripheral blood mononuclear cell, TAG triacylglycerides, UHPLC ultra-high performance liquid chromatography
^aThe study includes other nonrelevant metabolites (included in Additional file 1: Table S2)

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ISSN: 1865-3499

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