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Table 1 Baseline characteristics, biochemical parameters, plasma fatty acids, and omega-3 index of responders and non-responders to omega-3 supplementation

From: Differences in peripheral blood mononuclear cell gene expression and triglyceride composition in lipoprotein subclasses in plasma triglyceride responders and non-responders to omega-3 supplementation

 

Responders (n = 8)

Non-responders (n = 16)

  

Baseline

Change 7 weeks

 

Baseline

Change 7 weeks

 

P ‡

P ‡

Median/n

25th

75th

Median

25th

75th

P †

Median/n

25th

75th

Median

25th

75th

P †

Baseline

Δ 7 weeks

Gender (male/female)

3/5

      

5/11

      

1§

 

Intervention group (FO/oxFO)

2/6

      

10/6

      

0.19§

 

Age (years)

23.5

21.5

25.8

    

26.5

22.5

33

    

0.17

 

BMI (kg/m2)

22.4

21.2

22.9

    

22.0

21.2

23.6

    

0.98

 

Biochemical parameters

 Total-C (mM)

4.6

4.1

5.0

0.0

− 0.3

0.4

1

4.8

4.4

5.2

0.1

− 0.2

0.3

0.8

0.5

0.9

 LDL-C (mM)

2.4

2.0

3.1

0.2

− 0.3

0.5

0.5

2.8

2.3

3.1

0.1

− 0.2

0.2

0.8

0.7

0.6

 HDL-C (mM)

1.3

1.2

1.5

0.0

− 0.1

0.1

0.7

1.3

1.3

1.6

0.0

0.0

0.1

0.2

0.4

0.8

 TG (mM)

1.5

1.4

1.7

− 0.6

− 0.6

− 0.5

0.01*

0.8

0.7

1.1

0.0

0.0

0.0

0.6

0.01*

0.0001*

 Glucose (mM)

4.7

4.7

4.8

0.0

− 0.1

0.4

0.5

4.6

4.5

5.0

4.8

4.6

5.1

0.2

0.9

1

 18:1 n-9 (OA) (wt%)

24.74

21.40

26.09

− 3.86

−  5.51

− 2.25

0.01*

19.18

18.28

20.35

− 0.81

− 1.92

−  0.03

0.01*

0.007*

0.004*

 18:2 n-6 (LA) (wt%)

25.34

23.31

26.78

0.94

− 0.58

3.22

0.5

32.12

29.77

33.41

− 1.59

− 2.78

0.59

0.04*

0.009*

0.04*

 18:3 n-3 (ALA) (wt%)

0.71

0.52

0.76

− 0.23

− 0.34

−  0.04

0.01*

0.57

0.52

0.63

− 0.05

−  0.14

0.01

0.1

0.3

0.03*

 20:4 n-6 (AA) (wt%)

6.30

5.68

6.45

0.01

− 0.25

0.16

1

6.20

5.62

7.05

− 0.54

− 1.29

− 0.38

0.0004*

0.9

0.01*

 20:5 n-3 (EPA) (wt%)

0.50

0.44

0.70

1.90

1.79

2.27

0.01*

0.69

0.53

0.82

2.08

1.41

2.41

0.0005*

0.3

0.9

 22:5 n-3 (DPA) (wt%)

0.42

0.37

0.61

0.15

0.11

0.24

0.01*

0.53

0.47

0.58

0.15

0.13

0.25

0.0009*

0.6

0.9

 22:6 n-3 (DHA) (wt%)

1.70

1.46

2.01

2.35

1.57

2.67

0.01*

2.15

1.74

2.35

1.67

1.19

2.34

< 0.0001*

0.4

0.1

 omega-3 index (wt%)

4.6

4.5

4.9

2.9

2.25

3.25

0.02*

5.6

4.9

6.0

2.35

1.38

3.03

0.0004*

0.03*

0.2

  1. 25th 25th percentile, 75th 75th percentile, FO fish oil, oxFO oxidized fish oil, BMI body mass index, C cholesterol, TG triglycerides,, n- omega-, OA oleic acid, LA linoleic acid, ALA alpha-linolenic acid, AA arachidonic acid, EPA eicosapentaenoic acid, DPA docosapentaenoic acid, DHA docasahexaenoic acid, wt% weight%.
  2. † Change from baseline to 7 weeks tested with paired Wilcoxon signed rank test
  3. ‡ Difference between responder and non-responder at baseline and change after 7 weeks tested with Mann-Whitney U test
  4. § Difference between responders and non-responders is tested with a Fisher’s exact test
  5. *p < 0.05
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Genes & Nutrition

ISSN: 1865-3499

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