Mechanism of continuous high temperature affecting growth performance, meat quality, and muscle biochemical properties of finishing pigs

Ma, Xianyong; Wang, Li; Shi, Zibiao; Chen, Wei; Yang, Xuefen; Hu, Youjun; Zheng, Chuntian; Jiang, Zongyong

doi:10.1186/s12263-019-0643-9

Table 2 Differentially expressed genes related to energy metabolism, muscle structure, and stress response

From: Mechanism of continuous high temperature affecting growth performance, meat quality, and muscle biochemical properties of finishing pigs

Gene^a	Description	Fold change^b
Gene^a	Description	35AL vs. 22AL	22PF vs. 22AL	35AL vs. 22PF
Lipid metabolic process
ACSL1	Acyl-CoA synthetase long-chain family member 1	0.22		0.45
ITGAV	Integrin, alpha V	0.25
CD36	CD36 molecule	0.28
*FABP3*	Fatty acid binding protein 3	0.42	0.46
DLD	Sus scrofa dihydrolipoamide dehydrogenase	0.22		0.29
CPT1B	Carnitine palmitoyltransferase 1B	0.48
*LPL*	Lipoprotein lipase	0.35
SCD	Stearoyl-CoA desaturase	0.18
*DECR1*	2,4-Dienoyl CoA reductase 1, mitochondria	0.24	0.50	0.50
ACADL	Acyl-CoA dehydrogenase, long chain	0.47	0.39
ACADM	Acyl-CoA dehydrogenase	0.39		0.46
ACOX1	Acyl-CoA oxidase 1, palmitoyl	0.44
CYP2E1	Cytochrome P450, family 2, subfamily E, polypeptide 1	6.22		3.79
ATP5B	ATP synthase, H+ transporting, mitochondrial F1 complex	0.21		0.41
*FASN*	Sus scrofa fatty acid synthase	2.42
APOC3	Sus scrofa apolipoprotein C-III		4.99	0.29
CPT1A	Sus scrofa carnitine palmitoyltransferase 1A		0.45
*LPINI*	Sus scrofa lipin 1 mRNA	0.35	0.38	0.72
*PPARGC-1*	Sus scrofa peroxisome proliferator activated receptor gamma, coactivator 1 alpha (PPARGC-1)	2.37
Glucose metabolic process
UGP2	UDP-glucose pyrophosphorylase 2	0.16		0.40
GPI	Glucose-6-phosphate isomerase	0.20		0.34
GPD1	Glycerol-3-phosphate dehydrogenase 1	0.38		0.44
*PFKM*	Phosphofructokinase, muscle	0.36		0.45
TPI1	Triosephosphate isomerase 1	0.15		0.23
PKM2	Pyruvate kinase, muscle	0.14		0.23
PGM1	Phosphoglucomutase	0.35		0.33
*PCK1*	Sus scrofa phosphoenolpyruvate carboxykinase 1	2.42	2.42
Muscle structure development
SHOC2	Soc-2 suppressor of clear homolog	0.32		0.45
CASQ1	Calsequestrin 1 (fast-twitch, skeletal muscle)	0.46		0.46
MYH4	Myosin, heavy chain 4, skeletal muscle	0.29		0.43
ACTA1	Actin, alpha 1, skeletal muscle	0.32		0.36
ACTA2	Actin, alpha 2, smooth muscle,	0.39	0.40
ACTC1	Actin, alpha, cardiac muscle 1	0.435	0.26
BIN1	Bridging integrator 1	0.17		0.16
HMGB1	High mobility group box 1	0.45		0.34
SGCA	Sarcoglycan, alpha	0.25		0.40
ITGB1	Integrin, beta 1	0.18		0.27
CTNNB1	Catenin (cadherin-associated protein), beta 1	0.38		0.49
*MSTN*	Myostatin	0.41	1.14	0.36
*MYO1B*	Myosin IB	0.349	0.42
PPP3CB	Protein phosphatase 3, catalytic subunit, beta isozyme	0.18		0.28
CAV2	Caveolin 2	0.25		0.45
TPM2	Tropomyosin 2 (beta)	0.33		0.36
*TNNT3*	Troponin T type 3 (skeletal, fast)	0.39		0.45
*TNNI1*	Troponin I type 1 (skeletal, slow)	0.37
LMNA	Prelamin-A/C	0.27		0.44
MYOT	Sus scrofa myotilin	0.40	0.44
TPM3	Sus scrofa tropomyosin 3	0.41
TNNI3	Troponin I type 3	0.39	0.42	0.45
Cellular response to stress
GTF2H4	General transcription factor IIH subunit 4	2.13
ERCC1	Excision repair cross-complementing rodent repair complementation group 1	2.06
*HSPA1L*	Heat shock 70 kDa protein 1-like	2.20		2.64
MLH1	mutL homolog 1	2.09
GADD45A	Growth arrest and DNA-damage-inducible, alpha	2.04
CDKN1A	Cyclin-dependent kinase inhibitor 1A			3.78
MB	Sus scrofa myoglobin (MB)	0.12		0.25
CXCL10	Chemokine (C-X-C motif) ligand 10			2.58
MAPK14	Mitogen-activated protein kinase 14	3.02		2.11
TICAM2	Toll-like receptor adaptor molecule 2	3.35		2.02
Cellular response to hormone stimulus
NR3C1	Nuclear receptor subfamily 3, group C, member 1	0.48
*GHR*	Growth hormone receptor	0.27
ACVR1	Activin type I receptor	0.30
ADRB2	Adrenergic, beta-2- receptor	0.32		0.49
IFNGR2	Interferon gamma receptor 2	0.27
FOLR2	Folate receptor 2	0.47		0.44
ADIPOR1	Adiponectin receptor 1	0.48

^aGenes shown in boldface were used in qPCR verification
^bOnly the fold change of differentially expressed genes related to energy metabolism, muscle structure, and stress response are shown. Values > 1.0 show upregulation, and < 1.0 show downregulation

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