Fig. 4

Circuit diagrams of the logical parameters for the regulatory network of cellular metabolic flexibility. a) The circuit diagrams representing the entities other than PDK. Each entity has a single circuit diagram representing the respective set of parameters. b) Shows the four models of PDK regulation, differing on how the activators (Fatty Acids and Acetyl-CoA) are able to affect the activation of PDK in the presence of the inhibitor (Pyruvate). The tabulated logical parameters for all entities are provided as Additional file 3