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Table 3 Overview of the current level of validation of the candidate biomarkers of seaweed intake

From: Biomarkers of seaweed intake

Food item

Metabolites

Biofluid locations

Questionsa

1

2

3

4

5

6

7

8

Brown seaweed

Hydroxytrifuhalol A

Hydrolyzed urine

Y

U

Y

U

U

U

U

U

Brown seaweed

7-Hydroxyeckol

Hydrolyzed urine

Y

U

Y

U

U

U

U

U

Brown seaweed

C-O-C dimer of phloroglucinol

Hydrolyzed urine

Y

U

Y

U

U

U

U

U

Brown seaweed

Dioxinodehydroeckol glucuronide

Urine

Y

U

Y

U

U

U

U

U

Brown seaweed

Diphlorethol sulfate

Urine

Y

U

Y

U

U

U

U

U

Brown seaweed

Fucophloroethol glucuronide

Urine

Y

U

Y

U

U

U

U

U

Brown seaweed

Fucoxanthinol

Plasma

Y

U

Y

U

U

U

U

U

  1. aThe criteria are 1, plausibility; 2, dose response; 3, time response; 4, robustness; 5, reliability; 6, stability; 7, analytical performance; 8, reproducibility. The full text of questions Q1–Q8 is reported in Additional file 1: Text S1. Possible answers are Y (yes, the criterion is fulfilled for at least some use of the biomarker), N (no, the criterion has been investigated but it was not fulfilled), or U (uncertain, the criterion has not been verified or data is not available). The questions are based on the criteria outlined by Dragsted et al. [17]