Table 2 Frequency of NADSYN1/DHCR7 and GC variants in EUR, EAS and AFR groups

 rs3750997

60 (2356)

0.30 (0.25–0.36)

0.58^a (0.52–0.63)

0.65^a (0.59–0.70)

3.18e–12

0.59

EUR≠AFR and EAS

 rs1790325

45 (1854)

0.95 (0.89–1.02)

0.73^a (0.66–0.79)

0.57^a (0.50–0.63)

9.90e–10

0.61

EUR ≠ AFR and EAS

 rs11603330

60 (2356)

0.69 (0.64–0.73)

0.35 (0.31–0.40)

0.11 (0.07–0.16)

7.09e–26

0.86

EUR ≠ AFR ≠ EAS

 rs7928249

34 (2293)

0.29 (0.22–0.36)

0.66^a (0.58–0.74)

0.63^a (0.56–0.70)

1.06e-08

0.67

EUR ≠ AFR and EAS

 rs12800438

60 (2352)

0.30 (0.24–0.35)

0.63^a (0.57–0.68)

0.66^a (0.61–0.71)

3.04e–14

0.65

EUR ≠ AFR and EAS

 rs7944926

60 (2356)

0.30 (0.25–0.34)

0.63 (0.58–0.67)

0.86 (0.82–0.91)

1.68e–24

0.85

EUR ≠ AFR ≠ EAS

 rs3794060

60 (2356)

0.70 (0.66–0.75)

0.37 (0.33–0.42)

0.11 (0.07–0.15)

5.87e–26

0.87

EUR ≠ AFR ≠ EAS

 rs12280295

60 (2356)

0.00^a (− 0.04–0.04)

0.00^a (− 0.04–0.04)

0.23 (0.19–0.26)

1.57e–13

0.63

AFR ≠ EUR and EAS

 rs7041

60 (2354)

0.58 (0.55–0.61)

0.28 (0.25–0.31)

0.10 (0.07–0.13)

2.17e–30

0.91

EUR ≠ AFR ≠ EAS

 rs4364228

60 (2354)

0.09^a (0.06–0.13)

0.12^a (0.09–0.15)

0.45 (0.42–0.48)

2.16e–24

0.85

AFR ≠ EUR and EAS

 rs222047

60 (2356)

0.58 (0.55–0.61)

0.23 (0.20–0.26)

0.12 (0.09–0.14)

4.09e–31

0.91

EUR ≠ AFR ≠ EAS

 rs3737549

60 (2356)

0.00 (− 0.03–0.03)

0.14^a (0.11–0.17)

0.22^a (0.19–0.25)

6.72e–14

0.64

EUR ≠ AFR and EAS

 rs843006

60 (2355)

0.83 (0.80–0.86)

0.62 (0.59–0.65)

0.31 (0.28–0.35)

6.98e–30

0.90

EUR ≠ AFR ≠ EAS

 rs705117

60 (2356)

0.84 (0.81–0.88)

0.50 (0.46–0.53)

0.17 (0.14–0.20)

6.42e–36

0.94

EUR ≠ AFR ≠ EAS