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Table 2 Frequency of NADSYN1/DHCR7 and GC variants in EUR, EAS and AFR groups

From: Distribution of variants in multiple vitamin D-related loci (DHCR7/NADSYN1, GC, CYP2R1, CYP11A1, CYP24A1, VDR, RXRα and RXRγ) vary between European, East-Asian and Sub-Saharan African-ancestry populations

  Mean allelic frequency (95% CI)*   
 Sample sets (subjects)EUREASAFRpr2Distribution pattern#
NADSYN1/DHCR7
 rs375099760 (2356)0.30 (0.25–0.36)0.58a (0.52–0.63)0.65a (0.59–0.70)3.18e–120.59EUR≠AFR and EAS
 rs179032545 (1854)0.95 (0.89–1.02)0.73a (0.66–0.79)0.57a (0.50–0.63)9.90e–100.61EUR ≠ AFR and EAS
 rs1160333060 (2356)0.69 (0.64–0.73)0.35 (0.31–0.40)0.11 (0.07–0.16)7.09e–260.86EUR ≠ AFR ≠ EAS
 rs792824934 (2293)0.29 (0.22–0.36)0.66a (0.58–0.74)0.63a (0.56–0.70)1.06e-080.67EUR ≠ AFR and EAS
 rs1280043860 (2352)0.30 (0.24–0.35)0.63a (0.57–0.68)0.66a (0.61–0.71)3.04e–140.65EUR ≠ AFR and EAS
 rs794492660 (2356)0.30 (0.25–0.34)0.63 (0.58–0.67)0.86 (0.82–0.91)1.68e–240.85EUR ≠ AFR ≠ EAS
 rs379406060 (2356)0.70 (0.66–0.75)0.37 (0.33–0.42)0.11 (0.07–0.15)5.87e–260.87EUR ≠ AFR ≠ EAS
 rs1228029560 (2356)0.00a (− 0.04–0.04)0.00a (− 0.04–0.04)0.23 (0.19–0.26)1.57e–130.63AFR ≠ EUR and EAS
GC
 rs704160 (2354)0.58 (0.55–0.61)0.28 (0.25–0.31)0.10 (0.07–0.13)2.17e–300.91EUR ≠ AFR ≠ EAS
 rs436422860 (2354)0.09a (0.06–0.13)0.12a (0.09–0.15)0.45 (0.42–0.48)2.16e–240.85AFR ≠ EUR and EAS
 rs22204760 (2356)0.58 (0.55–0.61)0.23 (0.20–0.26)0.12 (0.09–0.14)4.09e–310.91EUR ≠ AFR ≠ EAS
 rs373754960 (2356)0.00 (− 0.03–0.03)0.14a (0.11–0.17)0.22a (0.19–0.25)6.72e–140.64EUR ≠ AFR and EAS
 rs22201660 (2327)0.85 (0.82–0.88)0.62 (0.59–0.65)0.37 (0.34–0.40)2.20e–300.91EUR ≠ AFR ≠ EAS
 rs22202060 23560.85 (0.82–0.88)0.62 (0.59–0.65)0.36 (0.33–0.39)1.54e–300.91EUR ≠ AFR ≠ EAS
 rs84300660 (2355)0.83 (0.80–0.86)0.62 (0.59–0.65)0.31 (0.28–0.35)6.98e–300.90EUR ≠ AFR ≠ EAS
 rs70511760 (2356)0.84 (0.81–0.88)0.50 (0.46–0.53)0.17 (0.14–0.20)6.42e–360.94EUR ≠ AFR ≠ EAS
  1. *Frequency values notated with the same letter are not significantly different from each other
  2. #EUR ≠ AFR ≠ EAS; allelic frequency differed between all geographic groups, EUR ≠ AFR and EAS; allelic frequency differed between EUR and both AFR and EAS, AFR ≠ EUR and EAS; allelic frequency differed between AFR and both EUR and EAS