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Table 4 Frequency of VDR, RXRα and RXRγ variants in EUR, EAS and AFR groups

From: Distribution of variants in multiple vitamin D-related loci (DHCR7/NADSYN1, GC, CYP2R1, CYP11A1, CYP24A1, VDR, RXRα and RXRγ) vary between European, East-Asian and Sub-Saharan African-ancestry populations

 Sample sets (subjects)Mean allelic frequency (95% CI)*  Distribution pattern#
 EUREASAFRpr2
VDR
 rs88644160 (2356)0.18 (0.16–0.21)0.05 (0.02–0.07)0.41 (0.38–0.43)1.66e–270.88EUR ≠ AFR ≠ EAS
 rs228334260 (2356)0.26 (0.22–0.29)0.49 (0.43–0.55)0.00 (− 0.04–0.05)6.70e–190.76EUR ≠ AFR ≠ EAS
 rs210730160 (2356)0.32 (0.29–0.35)0.67 (0.63–0.70)0.13 (0.10–0.16)1.91e–300.91EUR ≠ AFR ≠ EAS
 rs433408960 (2356)0.73 (0.68–0.77)0.57 (0.52–0.61)0.35 (0.30–0.39)1.95e–160.71EUR ≠ AFR ≠ EAS
 rs451603560 (2355)0.43 (0.41–0.45)0.03a (0.00–0.05)0.03a (0.01–0.05)3.68e–340.93EUR ≠ AFR and EAS
RXRα
 rs180534345 (1853)0.66a (0.63–0.69)0.65a (0.63–0.68)0.17 (0.14–0.19)6.81e–290.95AFR ≠ EUR and EAS
 rs180535244 (1822)0.69a (0.66–0.72)0.75a (0.72–0.78)0.26 (0.23–0.29)2.82e–270.95AFR ≠ EUR and EAS
 rs1088158246 (1881)0.74a (0.71–0.77)0.81a (0.78–0.83)0.25 (0.22–0.28)1.04e–300.96AFR ≠ EUR and EAS
 rs311857145 (1854)0.65a (0.62–0.68)0.69a (0.66–0.72)0.12 (0.09–0.15)9.27e–300.96AFR ≠ EUR and EAS
 rs381874045 (1853)0.40a,b,c (0.29–0.52)0.43a,b,c (0.32–0.53)0.59a,b,c (0.48–0.70)3.85e–020.10-
 rs73151645 (1852)1.00a (0.98–1.02)1.00a (0.98–1.02)0.59 (0.57–0.61)1.20e–310.96AFR ≠ EUR and EAS
 rs704043445 (1854)0.00a (− 0.01–0.02)0.00a (− 0.01–0.01)0.53 (0.52–0.54)4.26e–440.99AFR ≠ EUR and EAS
RXRγ
 rs28369560 (2356)0.44 (0.40–0.47)0.77a (0.73–0.80)0.85a (0.82–0.89)8.45e–250.85EUR ≠ AFR and EAS
 rs1206916060 (2356)0.94a (0.92–0.96)0.65 (0.62–0.67)0.92a (0.90–0.95)2.69e–240.85EAS ≠ AFR and EUR
 rs1080009860 (2345)0.05a (0.02–0.08)0.33 (0.30–0.36)0.03a (0.00–0.06)8.40e–210.80EAS ≠ AFR and EUR
 rs1048974560 (2343)0.09a (0.07–0.12)0.42 (0.40–0.45)0.03a (0.01–0.05)3.57e–330.92EAS ≠ AFR and EUR
  1. *Frequency values notated with the same letter are not significantly different from each other
  2. #EUR ≠ AFR ≠ EAS; allelic frequency differed between all geographic groups, EUR ≠ AFR and EAS; allelic frequency differed between EUR and both AFR and EAS, AFR ≠ EUR and EAS; allelic frequency differed between AFR and both EUR and EAS, EAS ≠ AFR and EUR; allelic frequency differed between EAS and both EUR and AFR