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Table 2 Effect of flaxseed oil supplementation on fatty acids status of erythrocytes

From: Effect of flaxseed oil supplementation on the erythrocyte membrane fatty acid composition and endocannabinoid system modulation in patients with coronary artery disease: a double-blind randomized controlled trial

VariableFlaxseed oil (n = 21)Placebo (n = 19)MD (95% CI), P value
LA (%)
 Before14.53 (6.22)15.59 (8.48)1.32 (− 4.26 to 6.90), 0.632a
 After9.68 (3.25)12.10 (3.94)2.89 (0.07 to 5.72), 0.045b
MD (95% CI), P valuec− 4.84 (− 9.16 to − 0.53), 0.031− 3.49 (− 7.18 to 0.19), 0.062 
AA (%)
 Before13.59 (5.64)11.59 (6.87)− 1.21 (− 6.07 to 3.65), 0.613a
 After9.56 (1.40)8.75 (1.56)− 1.06 (− 2.47 to 0.36), 0.135b
MD (95% CI), P valuec− 4.03 (− 7.46 to − 0.60), 0.026− 2.84 (− 6.76 to 1.07), 0.143 
ALA (%)
 Before0.20 (0.12)0.21 (0.11)0.01 (− 0.07 to 0.10), 0.679a
 After0.56 (0.24)0.22 (0.10)− 0.35 (− 0.51 to − 0.20), < 0.001b
MD (95% CI), P valuec0.37 (0.23 to 0.51), < 0.0010.004 (− 0.08 to 0.09), 0.925 
EPA (%)
 Before1.15 (0.60)1.08 (0.87)− 0.28 (− 0.84 to 0.27), 0.301a
 After1.06 (0.72)0.87 (0.50)− 0.29 (− 0.96 to 0.37), 0.364b
MD (95% CI), P valuec− 0.09 (− 0.51 to 0.32), 0.612− 0.21 (− 0.65 to 0.22), 0.305 
DHA (%)
 Before1.43 (0.87)1.24 (0.76)− 0.20 (− 0.83 to 0.43), 0.520a
 After1.36 (0.44)1.29 (0.46)− 0.08 (− 0.52 to 0.36), 0.704b
MD (95% CI), P valuec− 0.07 (− 0.80 to 0.65), 0.8220.05 (− 0.35 to 0.45), 0.796 
  1. Values are expressed as mean (SD)
  2. LA linoleic acid, AA arachidonic acid, ALA α-linolenic acid, EPA eicosapentaenoic acid, DHA docosahexaenoic acid, MD mean difference
  3. aIndependent samples t-test
  4. bAdjusted for baseline values, weight differences, and energy and fat intake changes using the analysis of covariance (ANCOVA) test
  5. cPaired-samples t-test