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Table 2 List of non-retained compounds for grapes/raisins and berries

From: Food intake biomarkers for berries and grapes

Food item

Compound

Biofluid

Reasons for exclusion

References

Raisin

p-Hydroxybenzoic acid

Plasma

Unspecific

[84]

Grape

Anthocyanins and its derivatives:

cyanidin-3-glucoside, cyanidin-3-glucuronide,

delphinidin-3-glucoside, delphinidin-3-glucuronide,

malvidin-3-glucoside, malvidin-3-glucuronide,

peonidin-3-glucoside, peonidin-3-glucuronide,

petunidin-3-glucoside, petunidin-3-glucuronide

Plasma/ urine/ ileal fluid

Unspecific, low bioavailability

[19, 55, 15, 157]

Flavan-3-ol metabolites and its derivatives:

catechin, catechin glucuronide, catechin sulfate, catechin sulfate glucuronide, epicatechin, epicatechin glucuronide, epicatechin sulfate, epicatechin sulfate glucuronide, epicatechin-3-O-gallate, O-methyl-(epi)catechin-O-glucuronide, O-methyl-(epi)catechin-O-sulfate, gallocatechin, epigallocatechin, epigallocatechin-O-glucuronide, O-methyl-(epi)gallocatechin-O-sulfate, 4′′-O-methyl-(epi)gallocatechin-O-sulfate, 4-hydroxy-5-(3,4-dihydroxyphenyl)valeric acid, 4-hydroxy-5-(dihydroxyphenyl)-valeric acid glucuronide, 4-hydroxy-5-(dihydroxyphenyl)-valeric acid sulfate,

5-(3,4′-Dihydroxyphenyl)-g-valerolactone, 5-(3′,4′-dihydroxyphenyl)-ɣ-valerolactone, 5-(3′,5′-dihydroxyphenyl)-ɣ-valerolactone, 5-(dihydroxyphenyl)-γ-valerolactone glucuronide, 5-(hydroxyphenyl)-γ-valerolactone glucuronide, 5-(hydroxy-methoxy-phenyl)-γ-valerolactone glucuronide

Plasma/ urine/ ileal fluid

Unspecific, common for many fruits and vegetables

[171, 157, 158, 99, 85, 150, 117, 23, 69, 29]

Procyanidin B1

Serum

Unspecific, common for many fruits

[149]

Benzoic acids and its derivatives:

gallic acid, O-methylgallic acid, O-methylgallic acid-3-O-sulfate, 3,4-O-dimethylgallic acid, hydroxybenzoic acid, hydroxy-dimethoxybenzoic acid glucuronide, 3,4-dihydroxybenzoic acid, 3-methoxy-4-hydroxybenzoic aicd, 3,5-dimethoxy-4-hydroxybenzoic aicd, syringic acid,

vanillic acid, vanillic acid-glucuronide, vanillic acid 4-sulfate, isovanillic acid, homovanillic acid, homovanillic acid 4-sulfate, pyrogallol, 2-O-methylpyrogallol, protocatechuic-O-glucoside,

hippuric acid, hydroxyhippuric acid

Plasma/ urine/ ileal fluid

Unspecific, common for many fruits and vegetables

[177, 79, 168, 158, 157, 131, 99, 85, 66, 150, 23, 69, 29]

Quercetin and its derivatives:

quercetin, quercetin glucuronide, 3′-O-methyl quercetin, dihydroquercetin

Plasma/ urine

Unspecific, common for many fruits and vegetables

[107, 33, 24, 150, 117]

Cinnamic acids and its derivtives:

caffeic acid, caffeic acid sulfate, dihydrocaffeic acid, dihydrocaffeic acid glucuronide, dihydrocaffeic acid sulfate,

ferulic acid, ferulic acid sulfate, dihydroferulic acid, isoferulic acid glucuronide, isoferulic acid sulfate, dihydroferulic acid, dihydroferulic acid glucuronide, dihydroferulic acid sulfate

p-coumaric acid, p-coumaric acid sulfate, m-dihydrocoumaric acid, dihydrocoumaric acid-O-sulfate, trans-caftaric acid, trans-coutaric acid, trans-fertaric acid,

dihydrosinapic acid glucuronide

Plasma/ urine/ ileal fluid

Unspecific, common for many fruits and vegetables

[79, 168, 157, 150, 23, 69, 29]

Phenylacetic-, and phenylpropionic acids and its derivatives:

2-hydroxyphenylacetic acid, 3-hydroxyphenylacetic acid, 4-hydroxyphenylacetic acid, 3,4-dihydroxyphenylacetic acid, 3,4-dihydroxyphenylacetic acid, hydroxyphenylacetic acid,

hydroxyphenylpropionic acid, dihydroxyphenylpropionic acid, dihydrosinapic acid glucuronide, hydroxyphenylpropionic aicd, dihydroxyphenylpropionic acid

Plasma/urine

Unspecific, common for many fruits and vegetables

[177, 168, 158, 85, 150, 69]

Mandelic acid metabolites

mandelic acid, 4-hydroxymandelic acid, vanilmandelic acid

Urine

Unspecific

[168, 158, 69])

Other metabolites:

feruloylglycine, vanilloylglycine, 6-sulfatoxymelatonin, enterodiol, tyrosine

Urine

Unspecific

[79, 71, 157, 85]

Total phenols, conjugated phenols

Plasma

Unspecific

[118, 6]

Naringenin

Urine

Unspecific

[79]

Urolithin A

Plasma

Unspecific, common for many fruits and nuts

[122]

Blueberry

Anthocyanidins, and its derivatves:

cyanidin, cyanidin glucuronide, cyanidin glycoside, cyanidin methyl glucoside, cyanidin methyl glucuronide,

delphinidin, delphinidin glucuronide, delphinidin glycoside, delphinidin glycoside methyl glucuronide, delphinidin methyl glucuronide, delphinidin methyl glycoside,

malvidin 3-glucoside, malvidin glucuronide, malvidin glycoside, malvidin glycoside glucuronide, malvidin glycoside sulfate, malvidin methyl glucuronide, malvidin methyl glycoside, pelargonidin glycoside, pelargonidin glucuronide, pelargonidin glycoside sulfate, pelargonidin methyl glucuronide, pelargonidin methyl glycoside, pelargonidin,

peonidin, peonidin glucuronide, peonidin glycoside, peonidin glycoside sulfate, peonidin methyl glucuronide, petunidin, petunidin glucuronide, petunidin glycoside, petunidin glycoside glucuronide, petunidin glycoside methyl, petunidin glycoside methyl glucuronide, petunidin methyl glucuronide

Urine, plasma

Unspecific, common for many fruits and vegetables, low bioavailability

[37, 80,81,82,83, 103, 105, 178, 112]

Flavan-3-ol metabolites and its derivatives:

(4r)-5-(3-hydroxyphenyl)-valerolactone-4-O-sulfate,

hydroxyphenyl-valerolactone*, dihydroxyphenyl-valerolactone*, hydroxy-(dihydroxyphenyl) pentenoic acid glucuronide*, hydroxy-(dihydroxyphenyl) valeric acid glucuronide I *, hydroxy-(dihydroxyphenyl) valeric acid glucuronide II *, hydroxy-(dihydroxyphenyl) valeric acid sulphate*, hydroxy-(dihydroxyphenyl) valeric acid glucuronide I *, hydroxy-(dihydroxyphenyl) valeric acid glucuronide II*, hydroxy-(dihydroxyphenyl) valeric acid sulphate*

Urine, plasma

Unspecific, common for many fruits and vegetables

[49, 50, 12, 2]

Benzoic acids and its derivatives:

benzoic acid, 2,3-dihydroxybenzoic acid, 2,4-dihydroxybenzoic acid,

2,5-dihydroxybenzoic acid, 2-hydroxybenzoic acid, 3-hydroxybenzoic acid, 4-hydroxybenzoic acid, 3-methoxybenzoic acid-3-sulfates

4-methoxybenzoic acid-4-sulfates 3,4-dihydroxybenzaldehyde,

3,5-dihydroxybenzyl alcohol, 3,5-dimethoxybenzoic acid methyl ester, 4-methylcatechol-O-sulfate, gallic acid, 3-O-methylgallic acid, 4-methylgallic acid-3-O-sulfate, protocatechuic acid, catechol glucuronide*, catechol sulphate*

hydroxy-(hydroxyphenyl)pentenoic acid glucuronide*, hydroxy-(hydroxy-methoxyphenyl)-pentenoic acid glucuronide I*, hydroxy-(hydroxy-methoxyphenyl)-pentenoic acid glucuronide II*, hydroxy-(hydroxyphenyl)pentenoic acid sulphate II*, hydroxy-(hydroxy-methoxyphenyl)-pentenoic acid sulphate*, hydroxy-(dihydroxyphenyl) pentenoic acid sulphate*, hydroxy-(hydroxyphenyl)pentenoic acid sulphate*, hydroxy-(dihydroxyphenyl) pentenoic acid glucuronide*, chlorogenic acid*,

1-methylpyrogallol-O-sulfate, 2-methylpyrogallol-O-sulfate,

pyrogallol-O-1-sulfate, pyrogallol-O-2-sulfate

2,4,6-trihydroxybenzaldehyde, 4-hydroxybenzaldehyde,

Benzoylglutamic acid

hippuric acid, 2-hydroxyhippuric acid, 3-hydroxyhippuric acid,

4-hydroxyhippuric acid, α-hydroxyhippuric acid, hydroxy hippuric acid sulphate*, hydroxy-methoxy hippuric acid*

Urine, plasma

Unspecific, common for many fruits and vegetables

[37, 131,132,133,134,135,136, 2, 34, 112, 3, 12, 160, 32, 137]

Cinnamic acids and its derivatives and conjugates

caffeic acid, caffeic acid 3-O-d-glucuronide, caffeic acid 4-O-d-glucuronide, cinnamic acid, dihydrocaffeic acid, dihydrocaffeic acid 3-O-D-glucuronide, dihydrocaffeic acid 3-O-sulfate, dihydroferulic acid, dihydroferulic acid 4-O-D-glucuronide, dihydroferulic acid 4-O-sulfate, dihydroisoferulic acid 3-O-D-glucuronide, dihydroisoferulic acid 3-O-sulfate, ferulic acid, ferulic acid 4-O-glucuronide, ferulic acid 4-O-sulfate, hydroxy-methoxy cinnamic acid glucuronide I (ferulic acid)*, hydroxy-dimethoxy cinnamic acid glucuronide (sinapic acid)*, hydroxy-methoxy cinnamic acid glucuronide II (ferulic acid)*, trimethoxy-hydro cinnamic acid glucuronide*, trimethoxy-hydro cinnamic acid glucuronide*

homovanillic acid, homovanillic acid sulfate, isoferulic acid, isoferulic acid 3-O-D-glucuronide, isoferulic acid 3-O-sulfate, isovanillic acid,

isovanillic acid glucuronide, vanillic acid, vanillic acid glucuronide, vanillic acid-4-O-sulfate, hydroxy-methoxy benzoic acid glucuronide I (Vanillic acid)*, hydroxy-methoxy benzoic acid glucuronide II (Vanillic acid)*, hydroxy-methoxy benzoic acid hexoside (vanillic acid glucoside)*,

m-coumaric acid, o-coumaric acid, p-coumaric acid, dihydro-m-coumaric acid, sinapic acid, syringic acid, hydroxy-dimethoxy benzoic acid sulphate (syringic acid)*, hydroxy-dimethoxy benzoic acid glucuronide I (syringic acid)*, hydroxy-dimethoxy benzoic acid glucuronide II (syringic acid)*

Urine, plasma

Unspecific, common for many fruits and vegetables

[49, 50, 135, 136, 132, 2, 112, 3, 185, 160, 91, 32, 137]

Phenyl acetic-, phenyl propionic acids, and its derivatives:

phenylacetic acid, 3,4-dihydroxyphenylacetic acid, 3-hydroxy-phenylacetic acid, 4-hydroxyphenylacetic acid, p-hydroxyphenyl-acetic

4-hydroxy-3-methoxyphenylpropionic acid, 3-(3′-hydroxyphenyl)-3-hydropropionic, 2-(4-hydroxyphenoxy)propionic acid, dihydroxyphenyl propionic acid glucuronide, hydroxyphenyl propionic acid sulphate

Urine, plasma

Unspecific, common for many fruits and vegetables

[49, 50, 135, 136, 134, 153, 32, 137]

Flavonols, its derivatives and conjugates

kaempferol, kaempferol-3-O-d-glucuronide,

quercetin, quercetin-3-O-d-glucuronide

Methyl-dihydro myricetin*

Urine, plasma

Unspecific, common for many fruits and vegetables

[49, 50, 135, 136, 134, 137, 2]

Flavan-3-ol metabolites

Catechin, epicatechin, (epi)catechin glucuronide, (epi)catechin sulfate, (epi)catechin glucuronide sulfate, (epi)catechin methyl

glucuronide, (epi)catechin methyl-sulfate

Urine, plasma

 

[12]

Abscisic acid*, hydroxy-abscisic acid glucuronide*, hydroxy-abscisic acid glucuronide*, hydroxy-abscisic acid*

Urine, serum

 

[91, 2]

Strawberry

Ellagic acids/ urolithins, its derivatives and conjugates

ellagic acid, urolithin A, urolithin A glucuronide, urolithin B, urolithin B glucuronide

Urine, plasma

Unspecific, common for many fruits and vegetables

[9, 14, 25, 26, 74, 129, 165, 148]

Anthocyanidins, its derivatves and conjugates

pelargonidin, pelargonidin-3-O-glucoside, pelargonidin-3-O-rutinoside, pelargonidin glucuronide four isomers, pelargodnidin sulfate, 5-carboxypyranopelargonidin-3-o-beta-glucopyranoside,

cyanidin-3,5-diglucoside, cyanidin-3-O-glucoside, cyanidin-3-O-rutinoside

Urine, plasma

Unspecific, common for many fruits and vegetables, low bioavailability

[4, 5, 22, 41, 48, 73,74,75,76, 113, 126, 147, 179, 20]

Benzoic acids, its derivatives and conjugates

4-hydroxybenzoic acid, 3-hydroxybenzoic acid, 3,4-dihydroxybenzoic acid, gallic acid, syringic acid, 4-hydroxyhippuric acid, salicylic acid, syringic acid, gentisic acid, vanillic acid, 3,4-dihydroxybenzaldehyde, 4-hydroxybenzaldehyde,

Urine, plasma

Unspecific, common for many fruits and vegetables

[4, 5, 129, 145, 148]

Cinnamic acids, its derivatives and conjugates

coumaric acid, caffeic acid, homovanillic acid, ferulic acid, synapic acid, vanillic acid, trans-cinnamic acid, isovanillic acid

Urine, plasma

Unspecific, common for many fruits and vegetables

[4, 5, 14, 145, 148]

Flavonols, its derivatives and conjugates

fisetin, fisetin-3-rutinoside,

kaempferol, kaempferol-3-(6′′malonylglucoside), kaempferol-3-coumaroylglucoside, kaempferol-3-glucoside, kaempferol-3-O-sulfate, kaempferol-glucuronide, dihydrokaempferol glucuronide, kaempferol-3-coumaroyl-glucoside

quercetin, quercetin-3-(6′′-caffeoylgalactoside), quercetin-3-galactoside, quercetin-3-glucoside, quercetin-glucuronide, quercetin-rutinoside, quercetin-sulfate, methylquercetin,

Urine, plasma

Unspecific, common for many fruits and vegetables

[5, 31, 41],

catechin

Plasma

Unspecific, common for many fruits and vegetables

[5]

hippuric acid

Plasma

Unspecific, common for many fruits and vegetables

[148]

Raspberry

Anthocyanidins, its derivatves and conjugates

cyanidin-3-O-(2′′-O-glucosyl)rutinoside, cyanidin-3-O-(2′′-O-xylosyl)rutinoside, cyanidin-3-O-glucoside, cyanidin-3-O-rutinoside, cyanidin-3-O-sophoroside, cyanidin-3-O-glucuronide,

pelargonidin-3-O-(2′′-O-glucosyl) rutinoside, pelargonidin-3-O-glucoside, pelargonidin-3-O-sophoroside, peonidin-3-O-glucoside

Urine, plasma

ileal fluid

Unspecific, common for many fruits and vegetables, low bioavailability

[70, 98, 184]

Ellagic acids/ urolithins, its derivatives and conjugates

ellagic acid, ellagic acid-O-glucuronide, dimethylellagic acid-O-glucuronide, urolithin A, urolithin A-O-glucuronide, urolithin A-sulfate, isourolithin A-O-glucuronide, urolithin B, urolithin B-3-O-glucuronide, (iso)urolithin A-sulfate-O-glucuronide

Urine, plasma

Unspecific,, common for many fruits and nuts

[70, 98, 184]

sanguiin H6

Ileal fluid

low bioavailability, low concentrations in biological fluids

[70]

Cinnamic acids and its derivatives:

caffeic acid, caffeic acid sulfate, caffeic acid-3′-sulfate, caffeoyl sulfate*, ferulic acid, ferulic acid-4′-sulfate, ferulic acid-4′-O-glucuronide, isoferulic acid-3’-O-glucuronide, isoferulic acid-3’-sulfate, isoferulic acid-3′-O-glucuronide, dihydrocaffeic acid-3′-sulfate, dihydroferulic acid glucuronide, dihydroferulic acid sulfate

Urine, plasma

Unspecific, common for many fruits and vegetables

[95, 98, 184]

Benzoic acids and its derivatives:

3-hydroxybenzoic acid-4-sulfate, 4-hydroxybenzoic acid, 4-hydroxybenzoic acid-3-sulfate, 2,6-dihydroxybenzoic acid,

2,3-dihydroxybenzoic acid, 2,4-dihydroxybenzoic acid, 3,4-dihydroxybenzoic acid, methyl-4-hydroxybenzoic acid, methyl-3,4-dihydroxybenzoic acid, 4-hydroxybenzoic acid glucuronide,

3-hydroxybenzoic acid glucuronide, gallic acid hippuric acid, 4-hydroxyhippuric acid, 3-hydroxyhippuric acid ,

3,4-dihydroxybenzoic acid sulfate

3,4-dihydroxybenzaldehyde, 4-hydroxybenzaldehyde glucuronide,

4-hydroxybenzaldehyde

Urine, plasma

Unspecific, common for many fruits and vegetables

[95, 98, 184]

Phenyl acetic-, phenyl propionic acids, and its derivatives:

3,4-dihydroxyphenyl acetic acid, 3′-methoxy-4′-hydroxyphenylacetic acid, 3,4-dihydroxyphenylacetic, 4-hydroxyphenylacetic acid, 3-hydroxyphenylacetic acid, 2-hydroxyphenylacetic acid, 3-hydroxyphenylpropionic acid sulfate,

3-hydroxyphenylpropionic acid

Urine, plasma

Unspecific, common for many fruits and vegetables

[98, 184]

Vitamin C

Urine

Unspecific, common for many fruits and vegetables

[95]

naringenin glucuronide

Urine

Unspecific, common for many fruits

[95]

methyl-epicatechin sulfate*

catechin glucuronide

Urine

Unspecific, common for many fruits and vegetables

[95, 184]

Endogenous metabolites:

indoxyl sulfate, adenine, alanine, asparagine, betaine, carnitine, citrate, formate, glutamine, glycine, histidine, lysine, N-phenylacetylglycine, phenylacetate, serine

Plasma

Endogenous metabolites

[86]

Blackberry

Anthocyanins and its derivatives:

cyanidin 3-glucoside, cyanidin 3-xyloside, cyanidin glucuronide, cyanidin diglucuronide, cyanidin sulfate, 4′-methyl-cyanidin-3-glucoside, cyanidin 3-glucoside, cyanidin 3-rutinoside, cyanidin glucoside glucuronide, cyanidin glucoside sulfate, cyanidin glucuronide (two isomers), methyl cyanidin glucoside glucuronide, methyl cyanidin glucuronide, cyanidin-3-rutinoside, cyanidin-3-xylosylrutinoside, cyanidin-3-glucoside, cyanidin-3-sambubioside, cyanidin 3-rutinoside, cyanidin 3-sambubioside, cyanidin 3-xylosylrutinoside, cyanidin-3-O-glucoside, methyl cyanidin 3-glucoside, methyl cyanidin 3-rutinoside, methyl cyanidin 3-sambubioside, methyl cyanidin 3-xylosylrutinoside,

peonidin-3-glucoside, peonidin 3-xyloside, peonidin glucuronide, peonidin-3-glucoside glucuronide, 3′methyl-cyanidin-3-glucoside

Urine, plasma

Unspecific, common for many fruits and vegetables

[47, 100, 123, 161];

Ellagic acids/ urolithins, and its derivatives:

ellagic acid, urolithin A, urolithin A glucuronide, urolithin B, urolithin B glucuronide, urolithin C, urolithin C glucuronide, urolithin D, urolithin D glucuronide, urolithin M5, methyl urolithin A, ellagic acid dimethyl ether glucuronide, ellagic acid dimethyl ether, hexahydroxydiphenyl

Spot urine

Unspecific, common for many fruits and nuts

[64, 65]

Others metabolites (2,3-dihydroxyisovaleric acid, 2,5-furandicarboxylic acid, 2-isopropylmalate, 2-oxindole-3-acetate, 3-[3-(sulfooxy)phenyl]propanoic acid, 3-hydroxyphenylacetic acid, 3-methylhistidine, 4-acetylphenol sulfate, 5-hydroxymethyl-2-furoic acid, abscisic acid, anthranilate, chiro-inositol, cinnamoylglycine, cis-aconitate, cortisol, cortisone, methyl-beta-glucopyranoside, n-(2-furoyl)glycine, N-acety-3-methylhistindine, N-acetylproline, xylitol, xylose, glycerol 3-phosphate

Plasma

Unspecific, common for many fruits and vegetables

[123]

Benzoic acids, and its derivatives:

4-methylcatechol sulfate, catechol, catechol sulfate,

hippuric acid, 3-hydroxyhippuric acid, 4-hydrixyhippuric acid,

2,4,6-trihydroxybenzoic acid

Urine, plasma

Unspecific, common for many fruits and vegetables

[64, 65, 123]

Cranberry

Anthocyanins and its derivatives:

cyanidin-3-arabinoside, cyanidin-3-galactoside, cyanidin-3-glucoside,

malvidine-3-glucoside,

peonidin-3-arabinoside, peonidin-3-galactoside, peonidin-3-glucoside

Urine, plasma

Unspecific, common for many fruits

[108] [119];,

Cinnamic acids and its derivatives:

ferulic acid, ferulic acid sulfate*, dihydro ferulic acid, dihydro ferulic acid 4-O-d-glucuronide, dihydro ferulic acid 4-O-sulfate, dihydro isoferulic acid 3-O-d-glucuronide, dihydro isoferulic acid 3-O-sulfate, ferulic acid 4-O-glucuronide, ferulic acid 4-O-sulfate, isoferulic acid, isoferulic acid 3-O-d-glucuronide, isoferulic acid 3-O-sulfate,

coumaric acid sulfate*, m-coumaric acid, o-coumaric acid, p-coumaric acid, cinnamic acid, 3,4-dihydroxyhydrocinnamic acid*, dihydroxyhydrocinnamic acid-3-O-glucuronide*

caffeic acid, caffeic acid 3-O-d-glucuronide, caffeic acid 4-O-d-glucuronide, dihydro caffeic acid, dihydro caffeic acid 3-O-d-glucuronide, dihydro caffeic acid 3-O-sulfate, dihydro caffeic acid 4-O-sulfate, vanillic acid, vanillic acid-4-O-sulfate, homovanillic acid, homovanillic acid sulfate, isovanillic acid, sinapic acid*, sinapic acid glucuronide, syringic acid,

Urine, plasma

Unspecific, common for many fruits and vegetables

[94, 135, 136, 48,49,50,51, 174, 175, 183, 27, 7]

Flavonols and its derivatives:

kaempferol, kaempferol-3-O-d-glucuronide, quercetin, quercetin-3-O-d-glucuronide, quercetin 3-galactose, quercetin 3-rhaminoside, quercetin 3-arabinose

myricetin, myricetin 3-arabinose, myricetin 3-galactoside

epicatechin, isorhamnetin,

Urine, plasma

Unspecific, common for many fruits and vegetables

[135, 136, 48,49,50,51, 174, 175, 27]

Benzoic acids, and its derivatives:

benzoic acid, 2-hydroxybenzoic acid, 3-hydroxybenzoic acid, 4-hydroxybenzoic acid, 2,3-dihydroxybenzoic acid, 2,4-dihydroxybenzoic acid, 2,5-dihydroxybenzoic acid, trihydroxybenzoic acid, quinic acid, 4-methylgallic acid-3-O-sulfate, protocatechuic acid, quinic acid*, vanilloloside*, trihydroxybenzoic acid*

hippuric acid, p-hydroxyhippuric acid* m-hydroxyhippuric acid*, o-hydroxyhippuric acid*, alfa-hydroxyhippuric acid*, salicyluric glucuronide*,

pyrogallol, pyrogallol-O-1-sulfate, pyrogallol-O-2-sulfate 1-methylpyrogallol-O-sulfate, 2-methylpyrogallol-O-sulfate,

3,4-dihydroxybenzaldehyde, 4-hydroxybenzaldehyde

catechol sulfate*, 4 -methylcatechol-O-sulfate, 3-O-Methylcatechin-sulphate*, 3,4-dihydroxyphenyl ethanol sulfate*

Urine, plasma

Unspecific, common for many fruits and vegetables

[94, 135, 136, 48,49,50,51, 174, 175, 183, 27, 7]

Phenyl acetic-, phenyl propionic acids, and its derivatives:

phenylacetic acid, 3-hydroxyphenylacetic acid, 4-hydroxyphenylacetic acid, 3,4-dihydroxyphenylacetic acid, 4-hydroxy-3-methoxyphenyl acetic acid, hydroxyphenylacetic*

2-(4-hydroxyphenoxy)propionic acid, 3-(hydroxyphenyl)proponic acid*

Urine, plasma

Unspecific, common for many fruits and vegetables

[94, 135, 136, 48,49,50,51, 174, 175, 183, 27]

(4r)-5-(3-hydroxyphenyl)-valerolactone-4-O-sulfate, 5-(3′,4′-dihydroxyphenyl)-γ- valerolactone*, 5-(3′,4′-dihydroxyphenyl)-γ-valerolactone-3′-O-sulphate*, 5-(3′,4′-dihydroxyphenyl)-γ- valerolactone-4′-O-sulphate* 5-(3′,4′,5′-trihydroxyphenyl)-γ-valerolactone-3′-O-sulphate*, 4-hydroxy-5-(dihydroxyphenyl)-valeric acid*, 5-(3′,4′-dihydroxyphenyl)-γ- valerolactone-3′-O-glucuronide*, 5-(3′,4′-dihydroxyphenyl)-γ-valerolactone-4′-O-glucuronide*, 5-(3′,4′-dihydroxyphenyl)-γ-valerolactone*, 5-(trihydroxphenyl)-γ-valerolactone*

Urine, plasma

Unspecific, common for many fruits and vegetables

[135, 136, 48,49,50,51, 7, 94]

chlorogenic acid

Urine

Unspecific, common for many fruits and vegetables and tea

[135, 136, 48,49,50,51]

Others metabolites:

aconitic acid*, citramalic acid*, dihydroxyquinoline*, glycerol 3-phosphate*, hydroxyoctadecanoic acid*, tyrosine*, vanilloylglycine*

Plasma

Unspecific,

[94]

Blackcurrant

Anthocyanidins and its derivatives:

cyanidin-3-O-rutinoside, cyanidin-3-O-glucoside, cyanidin glucuronide

delphinidin 3-O-rutinoside, delphinidin 3-O-glucoside, delphinidin glucuronide,

Urine, plasma

Unspecific, common for many fruits

[75, 76, 80, 105, 114, 115, 139]

Benzoic acids and its derivatives:

benozic acid, dihydroxy benzoic acid sulfate*, gallic acid, protocatechuic acid hippuric acid, 3-hydroxyhippuric acid, 4-hydroxyhippuric acid, catechol sulfate*

Urine, plasma

Unspecific, common for many fruits and vegetables

[164, 80, 75, 76, 139]

Cinnamic acids and its derivatives:

dimethoxy cinnamic acid sulfate*, ferulic acid, ferulic acid sulfate*

caffeic acid sulfate*

Urine, plasma

Unspecific, common for many fruits and vegetables

[80, 164]

Phenylacetic acid and its derivatives:

dihydroxy phenylacetic acid sulfate*

Urine

Unspecific, common for many fruits and vegetables

[164]

Quercetin

Plasma

Unspecific, common for many fruits and vegetables

[44]

Vitamin C

Plasma

Unspecific

[80]

uric acid

Plasma

Unspecific, endogenous compound

[80]

  1. * Metabolites found using untargeted metabolomics