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Table 5 Association between serum folate level with p53 methylation status and the risk of EPL and ESCC

From: Moderately high folate level may offset the effects of aberrant DNA methylation of P16 and P53 genes in esophageal squamous cell carcinoma and precancerous lesions

Serum folate (μg/L)

EPL [OR (95% CI)a, p for Interaction]

ESCC [OR (95% CI)a, p for Interaction]

p53U

p53M

p53U

p53M

Q1 (< 24.43)

1.00 (reference)

1.27 (0.62–2.61), 0.518

1.00 (reference)

2.34 (1.15–4.75), 0.019

Q2 (24.43–29.14)

0.77 (0.40–1.49), 0.440

1.30 (0.62–2.73), 0.494

0.66 (0.33–1.33), 0.246

1.43 (0.67–3.07), 0.361

Q3 (29.14–36.24)

0.38 (0.18–0.80), 0.011

0.23 (0.09–0.61), 0.003

0.49 (0.23–1.03), 0.060

1.04 (0.49–2.19), 0.923

Q4 (> 36.24)

0.38 (0.18–0.80), 0.011

0.41 (0.16–1.00), 0.050

0.16 (0.06–0.44), < 0.001

0.25 (0.08–0.74), 0.013

  1. U unmethylated, M methylated
  2. aAdjusted for gender, age, tobacco smoking, and alcohol drinking
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Genes & Nutrition

ISSN: 1865-3499

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