Table 2 Gene implicated in neurodevelopment and learning/memory abilities were differentially methylated in brain tissue of FA-S male offspring compared with the FA-N male offspring
GO term (BP) | DMGs associated |
|---|---|
Neural fold formation | 3 genes: Nodal, Cfl1 (hypermethylated), Cecr2 (hypomethylated) |
Forebrain development, lateral ventricle development, hindbrain development | 16 genes: Dlc1, App, Kdm2b, Sstr1, Neurog3, Hspa8, Aqp1, Dbi, Hoxa1, Neurod1 (hypermethylated), Dkk1, Htra2, Zic5, Apaf1, Smarca4, Tsku (hypomethylated) |
Neuron projection development | 16 genes: Stx3, Clmn, Itgb1, Pten, App, Npy, Cdnf, Sema7a, Ehd1 (hypermethylated), Ptprm, Ncdn, Camsap1, Shc1, Areg, Ikbkb, Runx3 (hypomethylated) |
Synapse maturation | 3 genes: Pten (hypermethylated), Erbb4, Shank1 (hypomethylated) |
Myelination | 9 genes: Dhh, Nab1, Afg3l2 (hypermethylated), Amigo1, Plp1, Nab2, Nfasc, Olig2, Tgfb1 (hypomethylated) |
Positive regulation of synaptic transmission, GABAergic, synaptic vesicle docking, long-term synaptic potentiation, long term synaptic depression | 15 genes: Tacr1, Tac1, Stx3, Syde1, Plk2, Dbi, Pten, Drd5 (hypermethylated), Erbb4, Prkce, Car7, Stx4, Slc8a2, S100b, Shank2 (hypomethylated) |
Memory | 11 genes: Pak6, Plk2, Slc6a4, Pten (hypermethylated), Slc8a2, Cebpb, Syt4, S100b, Cacna1d, Shank2, Neto1 (hypomethylated) |