Serum iron status and the risk of breast cancer in the European population: a two-sample Mendelian randomisation study

Table 2 Effect of transferrin concentration GWAS identified variants on breast cancer

SNPs	Chr: BP (Build 37)	Locus	Effect/other allele	Transferrin (μmol/L)		Overall breast cancer		ER-positive breast cancer		ER-negative breast cancer
SNPs	Chr: BP (Build 37)	Locus	Effect/other allele	Beta^b (SE)	P value	Beta^c (SE)	P value	Beta^c (SE)	P value	Beta^c (SE)	P value
rs744653	2: 190,378,750	WDR75–SLC40A1	T/C	0.068 (0.010)	1.35E−11	−0.009 (0.009)	0.3548	−0.007 (0.011)	0.500	−0.016 (0.016)	0.310
rs8177240	3: 133,477,701	TF	T/G	−0.380 (0.007)	8.43E−610	−0.014 (0.007)	0.039	−0.014 (0.008)	0.072	−0.012 (0.012)	0.304
rs9990333	3: 195,827,205	TFRC	T/C	−0.051 (0.007)	1.95E−13	−0.012 (0.007)	0.059	−0.015 (0.008)	0.062	−0.015 (0.012)	0.210
rs1800562^a	6: 26,093,141	HFE	A/G	−0.479 (0.016)	8.90E−196	−0.003 (0.014)	0.831	0.010 (0.016)	0.535	−0.027 (0.025)	0.288
rs1799945^a	6: 26,091,179	HFE	C/G	0.114 (0.010)	9.36E−30	−0.001 (0.009)	0.913	−0.003 (0.011)	0.804	−0.014 (0.016)	0.380
rs4921915	8: 18,272,466	NAT2	A/G	0.079 (0.009)	7.05E−19	−0.010 (0.007)	0.187	−0.012 (0.009)	0.186	−0.014 (0.013)	0.295
rs174577	11: 61,604,814	FADS2	A/C	0.062 (0.007)	2.28E−17	−0.006 (0.007)	0.341	0.002 (0.008)	0.761	−0.033 (0.012)	0.007
rs6486121	11: 13,355,770	ARNTL	T/C	−0.046 (0.007)	3.89E−10	−0.004 (0.006)	0.587	−0.002 (0.007)	0.809	−0.009 (0.012)	0.450
rs855791^a	22: 37,462,936	TMPRSS6	A/G	0.044 (0.007)	1.98E−09	−0.003 (0.006)	0.627	0.001 (0.008)	0.852	−0.013 (0.012)	0.255

^a3 SNPs used in the conservative analyses. GWAS genome-wide association studies, SNPs single nucleotide polymorphisms, Chr chromosome, BP base pair, SE standard error, ER oestrogen receptor
^bBeta units are per-allele effect estimates in transferrin concentrations
^cPer-allele logarithm of the odds ratios between breast cancer cases and controls

ISSN: 1865-3499