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Table 2 Tertiles of dietary BCAAs in relation to T2D according to the GRS of nested case-control participants

From: Genetic predisposition to impaired metabolism of the branched chain amino acids, dietary intakes, and risk of type 2 diabetes

GRS Dietary BCAAs (mg/g protein) P for trend P for interaction
T1 T2 T3
Total BCAAs      0.023
 < 4(n = 424) 1 0.75(0.45–1.26) 0.93(0.53–1.63) 0.71  
 ≥ 4(n = 444) 1 1.69(1.00–2.84) 2.40(1.39–4.12) 0.002  
Isoleucine      0.024
 < 4(n = 424) 1 0.82(0.49–1.39) 1.00(0.57–1.76) 0.93  
 ≥ 4(n = 444) 1 1.95(1.15–3.29) 2.55(1.48–4.38) 0.001  
Leucine      0.036
 < 4(n = 424) 1 0.87(0.52–1.46) 0.98(0.56–1.72) 0.91  
 ≥ 4(n = 444) 1 1.67(0.99–2.81) 2.38(1.39–4.10) 0.002  
Valine      0.041
 < 4(n = 424) 1 0.77(0.47–1.29) 0.89(0.51–1.56) 0.62  
 ≥ 4(n = 444) 1 1.43(0.85–2.39) 2.12(1.25–3.62) 0.005  
  1. The multivariate logistic regression was used for estimation of ORs and 95% confidence interval (CI)
  2. BCAAs, branched chain amino acids; GRS, genetic risk score; T2D, type 2 diabetes
  3. Results were adjusted for age, sex, BMI, waist circumference, current drinkers, current smokers, physical activity, diabetes treatment, cardiovascular disease, fruit intakes, poultry intakes, and total energy intakes