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Table 2 Tertiles of dietary BCAAs in relation to T2D according to the GRS of nested case-control participants

From: Genetic predisposition to impaired metabolism of the branched chain amino acids, dietary intakes, and risk of type 2 diabetes

GRS

Dietary BCAAs (mg/g protein)

P for trend

P for interaction

T1

T2

T3

Total BCAAs

    

0.023

 < 4(n = 424)

1

0.75(0.45–1.26)

0.93(0.53–1.63)

0.71

 

 ≥ 4(n = 444)

1

1.69(1.00–2.84)

2.40(1.39–4.12)

0.002

 

Isoleucine

    

0.024

 < 4(n = 424)

1

0.82(0.49–1.39)

1.00(0.57–1.76)

0.93

 

 ≥ 4(n = 444)

1

1.95(1.15–3.29)

2.55(1.48–4.38)

0.001

 

Leucine

    

0.036

 < 4(n = 424)

1

0.87(0.52–1.46)

0.98(0.56–1.72)

0.91

 

 ≥ 4(n = 444)

1

1.67(0.99–2.81)

2.38(1.39–4.10)

0.002

 

Valine

    

0.041

 < 4(n = 424)

1

0.77(0.47–1.29)

0.89(0.51–1.56)

0.62

 

 ≥ 4(n = 444)

1

1.43(0.85–2.39)

2.12(1.25–3.62)

0.005

 
  1. The multivariate logistic regression was used for estimation of ORs and 95% confidence interval (CI)
  2. BCAAs, branched chain amino acids; GRS, genetic risk score; T2D, type 2 diabetes
  3. Results were adjusted for age, sex, BMI, waist circumference, current drinkers, current smokers, physical activity, diabetes treatment, cardiovascular disease, fruit intakes, poultry intakes, and total energy intakes