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Table 5 Pleiotropy analysis of 11 selected plasma vitamin C genetic variants

From: Mendelian randomization to evaluate the effect of plasma vitamin C levels on the risk of Alzheimer’s disease

GWAS dataset MR-Egger intercept MR-PRESSO global test Heterogeneity test from IVW
Intercept 8. 95% CI P value P value I2 95% CI Q statistics P value
IGAP −0.013 [−0.030, 0.003] 0.116 0.5045 0.0% [0.0%, 55.6%] 0.5357
Maternal AD group from UK Biobank 0.004 [−0.006, 0.014] 0.416 0.4305 0.0% [0.0%, 39.0%] 0.7701
Paternal AD group from UK Biobank 0.004 [−0.013, 0.021] 0.616 0.297 32.3% [0.0%, 66.7%] 0.1409
UK Biobank AD proxy 0.004 [−0.005, 0.013] 0.354 0.1785 17.7% [0.0%, 57.9%] 0.2748
Cognitive performance 0.002 [−0.003, 0.008] 0.404 0.0035 66.7% [37.2% 82.4%] 8E-04
  1. The significance threshold is P < 0.05