Mendelian randomization to evaluate the effect of plasma vitamin C levels on the risk of Alzheimer’s disease

Genes & Nutrition

Table 5 Pleiotropy analysis of 11 selected plasma vitamin C genetic variants

GWAS dataset	MR-Egger intercept			MR-PRESSO global test	Heterogeneity test from IVW
GWAS dataset	Intercept	8. 95% CI	P value	P value	I²	95% CI	Q statistics P value
IGAP	−0.013	[−0.030, 0.003]	0.116	0.5045	0.0%	[0.0%, 55.6%]	0.5357
Maternal AD group from UK Biobank	0.004	[−0.006, 0.014]	0.416	0.4305	0.0%	[0.0%, 39.0%]	0.7701
Paternal AD group from UK Biobank	0.004	[−0.013, 0.021]	0.616	0.297	32.3%	[0.0%, 66.7%]	0.1409
UK Biobank AD proxy	0.004	[−0.005, 0.013]	0.354	0.1785	17.7%	[0.0%, 57.9%]	0.2748
Cognitive performance	0.002	[−0.003, 0.008]	0.404	0.0035	66.7%	[37.2% 82.4%]	8E-04

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