GWAS dataset | Method | OR/betaa | 95% CI | P value |
---|---|---|---|---|
IGAP AD | IVW | 0.94 | 0.81–1.10 | 4.64E−01 |
Weighted median | 1.02 | 0.83–1.24 | 8.83E−01 | |
MR-Egger | 1.09 | 0.85–1.40 | 5.07E−01 | |
MR-PRESSO | 0.94 | 0.81–1.10 | 4.71E−01 | |
UK Biobank AD proxy | IVW | 0.93 | 0.88–0.98 | 1.30E−02 |
Weighted median | 0.92 | 0.87–0.97 | 2.00E−03 | |
MR-Egger | 0.91 | 0.84–0.98 | 1.70E−02 | |
MR-PRESSO | 0.93 | 0.88–0.98 | 3.41E−02 | |
Maternal AD group from UK Biobank | IVW | 0.89 | 0.84–0.94 | 8.38E−05 |
Weighted median | 0.87 | 0.82–0.93 | 3.30E−05 | |
MR-Egger | 0.86 | 0.80–0.93 | 2.54E−04 | |
MR-PRESSO | 0.89 | 0.85–0.93 | 1.05E−03 | |
Paternal AD group from UK Biobank | IVW | 1.01 | 0.91–1.12 | 8.25E−01 |
Weighted median | 1.00 | 0.92–1.10 | 9.38E−01 | |
MR-Egger | 1.00 | 0.87–1.15 | 9.95E−01 | |
MR-PRESSO | 1.01 | 0.91–1.12 | 8.30E−01 | |
Cognitive performance | IVW | −0.005 | [−0.034, 0.025] | 0.754 |
Weighted median | −0.013 | [−0.051, 0.025] | 0.510 | |
MR-Egger | −0.004 | [−0.054, 0.045] | 0.865 | |
MR-PRESSO | −0.005 | [−0.034, 0.025] | 0.761 |