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Fig. 3 | Genes & Nutrition

Fig. 3

From: Mendelian randomization analysis of vitamin D in the secondary prevention of hypertensive-diabetic subjects: role of facilitating blood pressure control

Fig. 3

Mendelian randomization-inferred causality of vitamin D on incident clinical cardiovascular (CV) endpoints in hypertensive-diabetic subjects. Mendelian randomization showed vitamin D has causally protective effects against incident combined CV endpoints (Wald’s estimate: odds ratio [OR] = 0.86 [95%CI 0.75 to 0.95]) and incident myocardial infarction (OR = 0.76 [95%CI 0.60 to 0.90]) in 3746 hypertensive subjects. Any causality of vitamin D on incident CV death (OR = 0.87 [95%CI 0.58 to 1.19]), congestive heart failure (OR = 0.93 [95%CI 0.82 to 1.04]), ischemic stroke (OR = 0.90 [95%CI 0.67 to 1.09]), and peripheral vascular disease (OR = 0.85 [95%CI 0.52 to 1.30]) is neither supported nor excluded

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Genes & Nutrition

ISSN: 1865-3499

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