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Table 5 Interactions between APOA5 rs662799 polymorphism and red and processed meat consumption (serving/day) with the incidence of metabolic syndrome components in Korean adults

From: Interactions between red and processed meat consumption and APOA5 gene variants associated with the incidence of metabolic syndrome in Korean adults

 

Total (serving/day)

p interaction1

Men (serving/day)

p interaction1

Women (serving/day)

p interaction1

Tertile 1

Tertile 2

Tertile 3

Tertile 1

Tertile 2

Tertile 3

Tertile 1

Tertile 2

Tertile 3

Median

0.12

0.34

0.76

 

0.17

0.41

0.85

 

0.09

0.27

0.63

 

Ranges

0.00–0.22

0.22–0.50

0.50–6.13

 

0.00–0.27

0.27–0.56

0.56–6.13

 

0.00–0.17

0.17–0.42

0.42–5.96

 

Abdominal obesity

 Cases (n)/total (n)

643/1089

593/1088

568/1089

 

213/574

226/577

256/575

 

390/512

363/515

356/513

 

 AA

1.00 (reference)

1.12 (0.95–1.31)

1.27* (1.07–1.51)

0.171

1.00 (reference)

1.32* (1.01–1.73)

1.21 (0.91–1.62)

0.593

1.00 (reference)

1.12 (0.92–1.37)

1.15 (0.92–1.44)

0.228

 AG + GG

1.06 (0.91–1.24)

1.11 (0.94–1.31)

1.17 (0.98–1.40)

1.11 (0.85–1.45)

0.95 (0.72–1.26)

1.13 (0.84–1.51)

1.05 (0.85–1.28)

1.08 (0.87–1.33)

1.19 (0.95–1.49)

Elevated BP

 Cases (n)/total (n)

682/1089

628/1088

650/1089

 

397/574

372/577

388/575

 

300/512

264/515

239/513

 

 AA

1.00 (reference)

1.01 (0.87–1.18)

0.98 (0.83–1.15)

0.187

1.00 (reference)

0.95 (0.77–1.17)

0.82 (0.66–1.03)

0.181

1.00 (reference)

1.26 (1.00–1.58)

1.03 (0.80–1.32)

0.663

 AG + GG

0.96 (0.83–1.12)

0.93 (0.80–1.09)

0.92 (0.78–1.09)

0.88 (0.72–1.07)

0.85 (0.69–1.05)

0.85 (0.68–1.06)

1.07 (0.85–1.34)

1.10 (0.86–1.41)

1.00 (0.77–1.30)

Elevated FBG

 Cases (n)/total (n)

427/1089

467/1088

511/1089

 

290/574

303/577

318/575

 

165/512

163/515

166/513

 

 AA

1.00 (reference)

1.12 (0.93–1.36)

1.19 (0.98–1.45)

0.251

1.00 (reference)

1.01 (0.80–1.28)

0.94 (0.73–1.21)

0.653

1.00 (reference)

1.34 (1.00–1.81)

1.38* (1.01–1.90)

0.214

 AG + GG

0.97 (0.81–1.18)

1.11 (0.92–1.34)

1.15 (0.94–1.40)

0.91 (0.72–1.15)

0.98 (0.77–1.24)

1.03 (0.80–1.32)

1.01 (0.74–1.38)

1.17 (0.85–1.61)

1.34 (0.96–1.87)

Low HDL cholesterol

 Cases (n)/total (n)

796/1089

785/1088

737/1089

 

347/574

374/577

335/575

 

422/512

418/515

425/513

 

 AA

1.00 (reference)

1.09 (0.95–1.26)

0.93 (0.79–1.09)

< 0.001

1.00 (reference)

1.02 (0.81–1.27)

0.84 (0.65–1.07)

0.015

1.00 (reference)

0.98 (0.81–1.19)

1.02 (0.83–1.25)

0.001

 AG + GG

1.26* (1.10–1.45)

1.32* (1.15–1.53)

1.30* (1.11–1.51)

1.17 (0.95–1.45)

1.35* (1.09–1.68)

1.16 (0.92–1.48)

1.20 (0.99–1.45)

1.28* (1.05–1.56)

1.29* (1.05–1.58)

High triglyceride

 Cases (n)/total (n)

615/1089

626/1088

656/1089

 

369/574

379/577

402/575

 

265/512

241/515

241/513

 

 AA

1.00 (reference)

1.00 (0.84–1.19)

1.03 (0.85–1.24)

< 0.001

1.00 (reference)

1.01 (0.80–1.27)

1.24 (0.97–1.59)

< 0.001

1.00 (reference)

1.00 (0.77–1.31)

0.87 (0.65–1.16)

< 0.001

 AG+GG

1.53* (1.30–1.81)

1.41* (1.19–1.67)

1.50* (1.25–1.80)

1.41* (1.13–1.75)

1.39* (1.11–1.74)

1.60* (1.26–2.02)

1.75* (1.36–2.24)

1.41* (1.09–1.83)

1.58* (1.20–2.07)

  1. Data are presented as adjusted hazard ratios (HRs) and 95% confidence intervals (CIs)
  2. The total models were adjusted for residential area, age, sex, educational level, household income, drinking status, smoking status, physical activity, body mass index (BMI), energy intake (kcal/day), and intake of white meat (g/day), fish (g/day), vegetable (g/day), fruit (g/day), and dairy (g/day). The male and female models were adjusted for residential area, age, educational level, household income, drinking status, smoking status, physical activity, BMI, energy intake (kcal/day), and intake of white meat (g/day), fish (g/day), vegetable (g/day), fruit (g/day), and dairy (g/day)
  3. Abbreviations: BP Blood pressure, FBG Fasting blood glucose, HDL High-density lipoprotein
  4. 1p interaction was obtained by genotype and red and processed meat consumption as categorical variables and adjusted for covariates
  5. *p value < 0.05
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Genes & Nutrition

ISSN: 1865-3499

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