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Fig. 5 | Genes & Nutrition

Fig. 5

From: MicroRNA-205-5p plays a suppressive role in the high-fat diet-induced atrial fibrosis through regulation of the EHMT2/IGFBP3 axis

Fig. 5

Establishment of a HFD-induced atrial fibrosis model in mice. A Weight changes in mice during the experiment. B Weight gain of mice at the end of the experiment. C Fasting blood glucose level of mice. D ELISA was utilized for measuring the serum levels of TC, TG, HDL-C, and LDL-C. E Pathology of the left atrial tissues in mice was observed by H&E staining. F Masson staining was conducted for observing collagen deposition and atrial fibrosis. G, H Western blot analysis was conducted to examine the protein expression of key regulatory proteins of fibrosis (TGF-β1, TIMP1, and α-SMA) and hypertrophic markers (GATA4, Col I, and COL III). IK Expression of miR-205-5p, EHMT2 and IGFBP3 in the left atrial tissues of mice was determined using RT-qPCR and western blot analysis. *p < 0.05, vs. the sham group

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