Fig. 7

Upregulation of miR-205-5p or IGFBP3 attenuates the atrial metabolic disorder and inflammatory response induced by HFD. A The ionophoric proteins Nav1.5, CaV1.2, and Kv1.5 in mouse left atrial tissues were examined by western blot analysis. B, C. The levels of oxidative stress indicators MDA and SOD in atrial tissues were measured by ELISA. D–F. The expression levels of hs-CRP, TNF-α, and IL-1β in the left atrial tissues of mice in each group were measured by ELISA. G the tissue apoptosis was detected by TUNEL staining. H Expression of the key apoptotic enzyme caspase 3 was determined by western blot analysis. *p < 0.05, vs. the agomir-NC group; #p < 0.05 vs. the oe-NC group