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Fig. 4 | Genes & Nutrition

Fig. 4

From: Vitamin C attenuates predisposition to high-fat diet-induced metabolic dysregulation in GLUT10-deficient mouse model

Fig. 4

AA supplementation reduces HFD-induced eWAT inflammation and improves adipokine dysregulation in GLUT10G128E mice. Mice were treated as described in Fig. 1A. Data were collected from mice at the conclusion of feeding (20 weeks of age). A AA supplementation reduces crown-like structures (CLSs) in eWAT of HFD-fed GLUT10G128E mice. CLSs are a hallmark of eWAT inflammation. The eWAT sections were examined by H&E staining. Representing images are shown, and the red arrows point to a presumptive CLSs surrounding an adipocyte (left panel). The frequency of CLSs in eWAT sections were analyzed using ImageJ [54] and presented as CLS numbers per 100 adipocytes (right panel); n = 4 mice per group. BE AA supplementation improves HFD-induced adipokine dysregulation in GLUT10G128E mice. The serum levels of B adiponectin, C leptin, DIL-6, and E TNFα were determined. The data are shown as mean ± SEM. Statistical significance was determined by one-way ANOVA followed by Tukey’s test for multiple comparisons. The compact letter display indicates significant differences in pairwise comparisons; groups with different letters are significantly different

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