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Table 6 DEGs assigned to enriched modules associated with obesity traits in humans

From: Altered macronutrient composition and genetics influence the complex transcriptional network associated with adiposity in the Collaborative Cross

  Magenta module Red module Yellow module
Number of DEGs Genes associated with obesity traits in humans Number of DEGs Genes associated with obesity traits in humans Number of DEGs Genes associated with obesity traits in humans
Diet DEGs 0 NA 0 NA 3 Fars2, Mdfic, Abhd15
Strain DEGs 16 Macrod1a, Vegfb, Serp1 47 Fasna, Acacaa, Ppil1a 87 Nicn1a, Pnpla7a, Syne3a, Clocka
DEGs by diet and strain 5 Uggt1, Itih1, Serpina6 12 Spc24, Mipep, Cyb5b, Dlat 30 Fbxo21a, Brapa, Mgrn1a
  1. Multiple DEGs in the CC assigned to enriched modules were associated with obesity traits in humans in the GWAS catalog. The number of DEGs for the magenta, red, and yellow modules identified by WGCNA illustrates the larger contribution of differential expression by strain over diet. Examples of genes with human homologs associated with obesity traits are shown for each module, where a denotes genes that are significantly correlated with body fat % in the CC