Altered macronutrient composition and genetics influence the complex transcriptional network associated with adiposity in the Collaborative Cross

Table 6 DEGs assigned to enriched modules associated with obesity traits in humans

	Magenta module		Red module		Yellow module
	Number of DEGs	Genes associated with obesity traits in humans	Number of DEGs	Genes associated with obesity traits in humans	Number of DEGs	Genes associated with obesity traits in humans
Diet DEGs	0	NA	0	NA	3	Fars2, Mdfic, Abhd15
Strain DEGs	16	Macrod1^a, Vegfb, Serp1	47	Fasn^a, Acaca^a, Ppil1^a	87	Nicn1^a, Pnpla7^a, Syne3^a, Clock^a
DEGs by diet and strain	5	Uggt1, Itih1, Serpina6	12	Spc24, Mipep, Cyb5b, Dlat	30	Fbxo21^a, Brap^a, Mgrn1^a

Multiple DEGs in the CC assigned to enriched modules were associated with obesity traits in humans in the GWAS catalog. The number of DEGs for the magenta, red, and yellow modules identified by WGCNA illustrates the larger contribution of differential expression by strain over diet. Examples of genes with human homologs associated with obesity traits are shown for each module, where ^a denotes genes that are significantly correlated with body fat % in the CC

ISSN: 1865-3499