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Fig. 5 | Genes & Nutrition

Fig. 5

From: Role of muscle FOXO gene in exercise against the skeletal muscle and cardiac age-related defects and mortality caused by high-salt intake in Drosophila

Fig. 5

The effect of HSI, exercise, and FOXO-OE on climbing endurance and rapid climbing ability in flies. A Time to fatigue in 1-week-old and FOXO-OE flies. B Time to fatigue in 3-week-old and FOXO-OE flies. C Time to fatigue in 5-week-old and FOXO-OE flies. D Time to fatigue in 7-week-old and FOXO-OE flies. E Time to fatigue changed with age in FOXO-OE flies. F Climbing index in 3 s at different ages. For climbing endurance, the sample size was 200–220 flies for each group. P values for climbing endurance curves were calculated by the log-rank test. For climbing index measurement, the sample size was about 150–170 flies for each group. The 1-way analysis of variance (ANOVA) with least significant difference (LSD) tests was used to identify differences among the groups. Data are represented as means ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001; ns means no significant differences. Male MHC-gal4 flies were crossed to female FOXO-UAS-OE line a. “P{UAS-foxo.P}2 > MHC-gal4” and P{UAS-foxo.P}2 > MHC-gal4″ were represented as “FOXO-normal-expression-2 (FOXO-NE2)” and “FOXO-overexpression (FOXO-OE),” respectively

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Genes & Nutrition

ISSN: 1865-3499

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