Table 1 Casual effect of lipid biomarkers on early AMD
Exposures | SNPs | Methods | Estimate | Standard error | p-value | OR | 95% CI |
|---|---|---|---|---|---|---|---|
|  |  | Inverse variance weighted | 0.71 | 0.16 | 6.27 × 10−6 | 2.04 | 1.50–2.77 |
ApoA |  | Weighted median | 0.91 | 0.28 | 1.35 × 10−3 | 2.48 | 1.42–4.32 |
g/L | 237 | Weighted mode | 1.46 | 0.39 | 2.07 × 10−4 | 4.33 | 2.02–9.27 |
|  |  | MR Egger | 0.83 | 0.24 | 7.15 × 10−4 | 2.28 | 1.42–3.66 |
|  |  | Intercept |  − 1.41 × 10−3 | 2.25 × 10−3 | 5.33 × 10−1 |  |  |
|  |  | Inverse variance weighted |  − 0.65 | 0.16 | 6.60 × 10−5 | 0.52 | 0.38–0.72 |
ApoB |  | Weighted median |  − 0.54 | 0.23 | 1.84 × 10−2 | 0.58 | 0.37–0.91 |
g/L | 166 | Weighted mode |  − 0.58 | 0.18 | 1.85 × 10−3 | 0.56 | 0.39–0.80 |
|  |  | MR Egger |  − 0.52 | 0.22 | 1.67 × 10−2 | 0.59 | 0.39–0.91 |
|  |  | Intercept |  − 2.06 × 10−3 | 2.28 × 10−3 | 3.69 × 10−1 |  |  |
|  |  | Inverse variance weighted |  − 0.13 | 0.07 | 6.90 × 10−2 | 0.87 | 0.76–1.01 |
CHOL |  | Weighted median |  − 0.19 | 0.07 | 8.54 × 10−3 | 0.82 | 0.70–0.95 |
mmol/L | 63 | Weighted mode |  − 0.21 | 0.07 | 4.09 × 10−3 | 0.80 | 0.70–0.92 |
|  |  | MR Egger |  − 0.13 | 0.12 | 2.60 × 10−1 | 0.87 | 0.68–1.10 |
|  |  | Intercept | 5.11 × 10−4 | 6.63 × 10−3 | 9.38 × 10−1 |  |  |
|  |  | Inverse variance weighted | 0.22 | 0.04 | 2.61 × 10−8 | 1.25 | 1.15–1.35 |
HDL-C |  | Weighted median | 0.35 | 0.06 | 4.51 × 10−9 | 1.42 | 1.26–1.59 |
mmol/L | 344 | Weighted mode | 0.36 | 0.09 | 2.61 × 10−5 | 1.44 | 1.22–1.70 |
|  |  | MR Egger | 0.22 | 0.06 | 4.32 × 10−4 | 1.24 | 1.10–1.40 |
|  |  | Intercept | 1.73 × 10−4 | 1.80 × 10−3 | 9.23 × 10−1 |  |  |
|  |  | Inverse variance weighted |  − 0.10 | 0.03 | 2.03 × 10−3 | 0.90 | 0.85–0.96 |
LDL-C |  | Weighted median |  − 0.08 | 0.05 | 8.02 × 10−2 | 0.92 | 0.84–1.01 |
mmol/L | 350 | Weighted mode |  − 0.11 | 0.04 | 9.34 × 10−3 | 0.90 | 0.82–0.97 |
|  |  | MR Egger |  − 0.11 | 0.05 | 1.68 × 10−2 | 0.90 | 0.82–0.98 |
|  |  | Intercept | 4.04 × 10−4 | 1.66 × 10−3 | 8.08 × 10−1 |  |  |
|  |  | Inverse variance weighted |  − 1.10 × 10−4 | 5.43 × 10−4 | 8.39 × 10−1 | 1 | 0.999–1.001 |
|  |  | Weighted median | 2.06 × 10−5 | 6.39 × 10−4 | 9.74 × 10−1 | 1 | 0.999–1.001 |
Lp(a) | 19 | Weighted mode |  − 3.76 × 10−6 | 5.92 × 10−4 | 9.95 × 10−1 | 1 | 0.999–1.001 |
nmol/L |  | MR Egger | 7.27 × 10−4 | 7.91 × 10−4 | 3.71 × 10−1 | 1.001 | 0.999–1.002 |
|  |  | Intercept |  − 1.73 × 10−2 | 1.22 × 10−2 | 1.73 × 10−1 |  |  |
|  |  | Inverse variance weighted |  − 0.26 | 0.04 | 5.02 × 10−10 | 0.77 | 0.71–0.84 |
|  |  | Weighted median |  − 0.25 | 0.06 | 8.30 × 10−5 | 0.78 | 0.68–0.88 |
TG | 295 | Weighted mode |  − 0.20 | 0.06 | 7.30 × 10−4 | 0.82 | 0.73–0.92 |
mmol/L |  | MR Egger |  − 0.24 | 0.06 | 2.14 × 10−4 | 0.79 | 0.69–0.89 |
|  |  | Intercept |  − 8.18 × 10−4 | 1.91 × 10−3 | 6.69 × 10−1 |  |  |