Causal relationship between dietary salt intake and dementia risk: Mendelian randomization study

Genes & Nutrition

Table 2 Heterogeneity and pleiotropy estimates for the associations between dietary salt intake and dementia

Exposures/outcome	Heterogeneity test (MR-Egger)		Pleiotropy test			MR-PRESSO
Exposures/outcome	Q	p-value	Egger intercept	SE	p-value	Causal estimate	SD	p-value
Dietary salt intake/AD	71.262	0.601	− 0.023	0.010	0.035	0.322	0.229	0.164
Dietary salt intake/VaD	67.110	0.702	− 0.003	0.031	0.916	0.658	0.636	0.304
Dietary salt intake/LBD	70.986	0.445	0.009	0.016	0.557	− 0.001	0.351	0.997
Dietary salt intake/dementia	79.219	0.347	− 0.012	0.008	0.156	0.433	0.180	0.019

Abbreviations: AD Alzheimer’s disease, LBD Lewy body dementia, MR-Egger Mendelian randomization-Egger, MR-PRESSO pleiotropy residual sum and outlier, SE standard error, VaD vascular dementia

ISSN: 1865-3499