Fig. 8

Fisetin affects multiple pathways implicated in brain aging. As discussed in this article or elsewhere, fisetin can increase neuronal function and survival through maintenance of redox homeostasis, activating neurotrophic factor signaling pathways [76], regulating protein homeostasis through effects on proteasome activity and protein aggregation and inhibiting inflammatory responses. Fisetin can also enhance cognitive function. Therefore, it has the potential to act as a multi-factorial drug for reducing the age-associated decline in brain function