Akaishi T, Morimoto T, Shibao M, Watanabe S, Sakai-Kato K, Utsunomiya-Tate N, Abe K (2008) Structural requirement for the flavonoid fisetin in inhibiting fibril formation of amyloid β protein. Neurosci Lett 444:280–285
Article
PubMed
CAS
Google Scholar
Arai Y, Watanabe S, Kimira M, Shimoi K, Mochizuki R, Kinae N (2000) Dietary intakes of flavonols, flavones and isoflavones by Japanese women and the inverse correlation between quercetin intake and plasma LDL and cholesterol concentration. J Nutr 130:2243–2250
PubMed
CAS
Google Scholar
Ballatori N, Krance SM, Notenboom S, Shi S, Tieu K, Hammond CL (2009) Glutathione dysregulation and the etiology and progression of human diseases. Biol Chem 390:191–214
Article
PubMed
CAS
Google Scholar
Barad M, Bourtchouladze R, Winder DG, Golan H, Kandel E (1998) Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory. Proc Natl Acad Sci USA 95:15020–15025
Article
PubMed
CAS
Google Scholar
Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA (1990) Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 87:1620–1624
Article
PubMed
CAS
Google Scholar
Beckman JS, Ischiropoulos H, Zhu L, van der Woerd M, Smith C, Chen J, Harrison J, Martin JC, Tsai M (1992) Kinetics of superoxide dismutase- and iron-catalyzed nitration of phenolics by peroxynitrite. Arch Biochem Biophys 298:438–445
Article
PubMed
CAS
Google Scholar
Beckman KB, Ames BN (1998) The free radical theory of aging matures. Physiol Rev 78:547–581
PubMed
CAS
Google Scholar
Betarbet R, Sherer TB, Greenamyre JT (2005) Ubiquitin–proteasome system and Parkinson’s disease. Exp Neurol 191:S17–S27
Article
PubMed
CAS
Google Scholar
Bevins RA, Besheer J (2006) Object recognition in rats and mice: a non-trial non-matching-to-sample learning task to study ‘recognition memory’. Nat Protoc 1:1306–1311
Article
PubMed
Google Scholar
Blalock EM, Chen K-C, Sharrow K, Herman JP, Porter NM, Foster TC, Landfield PW (2003) Gene microarrays in hippocampal aging: statistical profiling identifies novel processes correlated with cognitive impairment. J Neurosci 23:3807–3819
PubMed
CAS
Google Scholar
Bliss TVP, Collingridge GL (1993) A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361:31–39
Article
PubMed
CAS
Google Scholar
Burdo J, Schubert D, Maher P (2008) Glutathione production is regulated via distinct pathways in stressed and non-stressed cortical cultures. Brain Res 1189:12–22
Article
PubMed
CAS
Google Scholar
Carlezon WA, Duman RS, Nestler EJ (2005) The many faces of CREB. Trends Neurosci 28:436–445
Article
PubMed
CAS
Google Scholar
Carter GW, Young PR, Albert DH, Bouska J, Dyer R, Bell RL, Summers JB, Brooks DW (1991) 5-Lipoxygenase inhibitory activity of zileuton. J Pharmacol Exp Ther 256:929–937
PubMed
CAS
Google Scholar
Chan JY, Kwong M (2000) Impaired expression of glutathione synthetic enzyme genes in mice with targeted deletion of the Nrf2 basic-leucine zipper protein. Biochim Biophys Acta 1517:19–26
PubMed
CAS
Google Scholar
Chen C, Kong ANT (2004) Dietary chemopreventive compounds and ARE/EpRE signaling. Free Radic Biol Med 36:1505–1516
Article
PubMed
CAS
Google Scholar
Chen TJ, Jeng JY, Lin CW, Wu CY, Chen YC (2006) Quercetin inhibition of ROS-dependent and -independent apoptosis in rat glioma C6 cells. Toxicology 223:113–126
Article
PubMed
CAS
Google Scholar
Chinnici CM, Yao Y, Practico D (2007) The 5-lipoxygenase enzymatic pathway in the mouse brain: young versus old. Neurobiol Aging 28:1457–1462
Article
PubMed
CAS
Google Scholar
Chung KKK, Dawson VL, Dawson TM (2001) The role of the ubiquitin-proteasomal pathway in Parkinson’s disease and other neurodegenerative disorders. Trends Neurosci 24:S7–S14
Article
PubMed
CAS
Google Scholar
Ciechanover A (2005) Proteolysis: from the lysosome to ubiquitin and the proteasome. Nat Rev Mol Cell Biol 6:79–86
Article
PubMed
CAS
Google Scholar
Ciechanover A, Brundin P (2003) The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg. Neuron 40:427–446
Article
PubMed
CAS
Google Scholar
Dilger RN, Johnson RW (2008) Aging, microglial priming, and the discordant central inflammatory response to signals from the peripheral immune system. J Leukoc Biol 84:932–939
Article
PubMed
CAS
Google Scholar
Ding Q, Keller JN (2001) Proteasomes and proteasome inhibition in the central nervous system. Free Radic Biol Med 31:574–584
Article
PubMed
CAS
Google Scholar
Dringen R (2005) Oxidative and antioxidative potential of brain microglial cells. Antioxid Redox Signal 7:1223–1233
Article
PubMed
CAS
Google Scholar
Droge W, Schipper HM (2007) Oxidative stress and aberrant signaling in aging and cognitive decline. Aging Cell 6:361–370
Article
PubMed
CAS
Google Scholar
Eliasson MJL, Huang Z, Ferrante RJ, Sasamata M, Molliver ME, Snyder SH, Moskowitz MA (1999) Neuronal nitric oxide synthase activation and peroxynitrite formation in ischemic stroke linked to neuronal damage. J Neurosci 19:5910–5918
PubMed
CAS
Google Scholar
Farooqui T, Farooqui AA (2008) Aging: an important factor for the pathogenesis of neurodegenerative diseases. Mech Ageing Dev 130:203–215
Article
PubMed
CAS
Google Scholar
Firuzi O, Zhuo J, Chinnici CM, Wisniewski T, Pratico D (2008) 5-Lipoxygenase gene disruption reduces amyloid-beta pathology in a mouse model of Alzheimer’s disease. FASEB J 22:1169–1178
Article
PubMed
CAS
Google Scholar
Garden GA, Moller T (2006) Microglia biology in health and disease. J Neuroimmune Pharmacol 1:127–137
Article
PubMed
Google Scholar
Griffith OW, Meister A (1979) Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine). J Biol Chem 254:7558–7560
PubMed
CAS
Google Scholar
Harman D (1956) Aging: a theory based on free radical and radiation chemistry. J Gernontol 11:298–300
CAS
Google Scholar
Heim KE, Tagliaferro AR, Bobilya DJ (2002) Flavonoid antioxidants: chemistry, metabolism and structure–activity relationships. J Nutr Biochem 13:572–584
Article
PubMed
CAS
Google Scholar
Hendler SS (2008) PDR for nutritional supplements, 2nd edn. Thomson Reuters, Cambridge
Google Scholar
Hou D-X, Fukuda M, Johnson JA, Miyamori K, Ushikai M, Fujii M (2001) Fisetin induces transcription of NADPH:quinone oxidoreductase gene through an antioxidant responsive element-involved activation. Int J Oncol 18:1175–1179
PubMed
CAS
Google Scholar
Ischiropoulos H, Zhu L, Chen J, Tsai M, Martin JC, Smith CD, Beckman JS (1992) Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase. Arch Biochem Biophys 298:431–437
Article
PubMed
CAS
Google Scholar
Ishige K, Schubert D, Sagara Y (2001) Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms. Free Radic Biol Med 30:433–446
Article
PubMed
CAS
Google Scholar
Ishii T, Itoh K, Takahashi S, Sato H, Yanagawa T, Yasutake K, Bannai S, Yamamoto M (2000) Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages. J Biol Chem 275:16023–16029
Article
PubMed
CAS
Google Scholar
Johannessen M, Delghandi MP, Moens U (2004) What turns CREB on? Cell Signal 16:1211–1227
Article
PubMed
CAS
Google Scholar
Joseph JA, Shukitt-Hale B, Denisova NA, Bielinski D, Martin A, McEwen JJ, Bickford PC (1999) Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation. J Neurosci 19:8114–8121
PubMed
CAS
Google Scholar
Keller JN, Hanni KB, Markesbery WR (2000) Possible involvement of proteasome inhibition in aging: implications for oxidative stress. Mech Ageing Dev 113:61–70
Article
PubMed
CAS
Google Scholar
Kensler TW, Wakabayashi N, Biswal S (2007) Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol 47:89–116
Article
PubMed
CAS
Google Scholar
Kim H, Park B-S, Lee K-G, Choi CY, Jang SS, Kim Y-H, Lee S-E (2005) Effects of naturally occurring compounds on fibril formation and oxidative stress of β-amyloid. J Agric Food Chem 53:8537–8541
Article
PubMed
CAS
Google Scholar
Kisselev AF, Goldberg AL (2001) Proteasome inhibitors: from research tools to drug candidates. Chem Biol 8:739–758
Article
PubMed
CAS
Google Scholar
Kwak M-K, Kensler TW (2006) Induction of 26S proteasome subunit PSMB5 by the bifunctional inducer 3-methylcholanthrene through the Nrf2-ARE, but not the AhR/Arnt-XRE, pathway. Biochem Biophys Res Commun 345:1350–1357
Article
PubMed
CAS
Google Scholar
Kwak M-K, Wakabayashi N, Greenlaw JL, Yamamoto M, Kensler TW (2003) Antioxidants enhance mammalian proteasome expression through the Keap1-Nrf2 signaling pathway. Mol Cell Biol 23:8786–9794
Article
PubMed
CAS
Google Scholar
Kwak M-K, Huang B, Chang H, Kim J-A, Kensler TW (2007) Tissue specific increase of the catalytic subunits of the 26S proteasome by indirect antioxidant dithiolethione in mice: enhanced activity for degradation of abnormal protein. Life Sci 80:2411–2420
Article
PubMed
CAS
Google Scholar
Kwak M-K, Wakabayashi N, Itoh K, Motohashi H, Yamamoto M, Kensler TW (2003) Modulation of gene expression by cancer chemopreventative dithiolethiones through the Keap1-Nrf2 pathway. J Biol Chem 278:8135–8145
Article
PubMed
CAS
Google Scholar
Lai M-Y, Hsiu S-L, Tsai S-Y, Hou Y-C, Chao P-DL (2003) Comparison of metabolic pharmacokinetics of baicalin and baicalein in rats. J Pharm Pharmacol 55:205–209
Article
PubMed
Google Scholar
Laughton MJ, Evans PJ, Moroney MA, Hoult JRS, Halliwell B (1991) Inhibition of mammalian 5-lipoxygenase and cyclo-oxygenase by flavonoids and phenolic dietary additives. Biochem Pharmacol 42:1673–1681
Article
PubMed
CAS
Google Scholar
Liu R-M (2002) Down-regulation of γ-glutamylcysteine synthetase regulatory subunit gene expression in rat brain tissue during aging. J Neurosci Res 68:344–351
Article
PubMed
CAS
Google Scholar
Liu R-M, Choi J (2000) Age-associated decline in γ-glutamylcysteine synthetase gene expression in rats. Free Radic Biol Med 28:566–574
Article
PubMed
CAS
Google Scholar
Lu T, Pan Y, Kao S-Y, Li C, Kohane I, Chan J, Yankner BA (2004) Gene regulation and DNA damage in the ageing human brain. Nature 429:883–891
Article
PubMed
CAS
Google Scholar
Maher P (2005) The effects of stress and aging on glutathione metabolism. Ageing Res Rev 4:288–314
Article
PubMed
CAS
Google Scholar
Maher P (2006) A comparison of the neurotrophic activities of the flavonoid fisetin and some of its derivatives. Free Radic Res 40:1105–1111
Article
PubMed
CAS
Google Scholar
Maher P (2008) Proteasome inhibitors prevent oxidative stress-induced nerve cell death by a novel mechanism. Biochem Pharmacol 75:1994–2006
Article
PubMed
CAS
Google Scholar
Maher P, Hanneken A (2005) Flavonoids protect retinal ganglion cells from oxidative stress-induced death. Invest Ophthalmol Vis Sci 46:4796–4803
Article
PubMed
Google Scholar
Maher P, Akaishi T, Abe K (2006) Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory. Proc Natl Acad Sci USA 103:16568–16573
Article
PubMed
CAS
Google Scholar
Maher P, Salgado KF, Zivin JA, Lapchak PA (2007) A novel approach to screening for new neuroprotective compounds for the treatment of stroke. Brain Res 1173:117–125
Article
PubMed
CAS
Google Scholar
Manach C, Williamson G, Morand C, Scalbert A, Remesy C (2005) Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr 81:230S–242S
PubMed
CAS
Google Scholar
Mayr B, Montminy M (2001) Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat Rev Mol Cell Biol 2:599–609
Article
PubMed
CAS
Google Scholar
Meister A, Anderson ME (1983) Glutathione. Ann Rev Biochem 52:711–760
Article
PubMed
CAS
Google Scholar
Middleton E, Kandaswami C, Theoharides TC (2000) The effects of flavonoids on mammalian cells: implications for inflammation, heart disease and cancer. Pharmacol Rev 52:673–751
PubMed
CAS
Google Scholar
Mosoni L, Breuille D, Buffiere C, Obled C, Mirand PP (2004) Age-related changes in glutathione availability and skeletal carbonyl content in healthy rats. Exp Gerontol 39:203–210
Article
PubMed
CAS
Google Scholar
Muller FL, Lustgarten MS, Jang Y, Richardson A, Van Remmen H (2007) Trends in oxidative aging theories. Free Radic Biol Med 43:477–503
Article
PubMed
CAS
Google Scholar
Myhrstad MCW, Carlsen H, Nordstrom O, Blomhoff R, Moskaug JO (2002) Flavonoids increase the intracellular glutathione level by transactivation of the γ-glutamylcysteine synthetase catalytical subunit promoter. Free Radic Biol Med 32:386–393
Article
PubMed
CAS
Google Scholar
Nguyen T, Sherratt PJ, Pickett CB (2003) Regulatory mechanisms controlling gene expression mediated by the antioxidant response element. Annu Rev Pharmacol Toxicol 43:233–260
Article
PubMed
CAS
Google Scholar
Palomero J, Galan AI, Munoz ME, Tunon MJ, Gonzalez-Gallego J, Jimenez R (2001) Effects of aging on the susceptibility to the toxic effects of cyclosporin A in rats. Changes in liver glutathione and antioxidant enzymes. Free Radic Biol Med 30:836–845
Article
PubMed
CAS
Google Scholar
Phillis JW, Horrocks LA, Farooqui AA (2006) Cyclooxygenases, lipoxygenases, and epoxygenases in CNS: their role and involvement in neurological disorders. Brain Res Rev 52:201–243
Article
PubMed
CAS
Google Scholar
Prasain JK, Barnes S (2007) Metabolism and bioavailability of flavonoids in chemoprevention: current analytical strategies and future prospects. Mol Pharm 4:846–864
Article
PubMed
CAS
Google Scholar
Radi R, Beckman JS, Bush KM, Freeman BA (1991) Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide. J Biol Chem 266:4244–4250
PubMed
CAS
Google Scholar
Rathbun WB, Murray DL (1991) Age-related cysteine uptake as rate limiting in glutathione synthesis and glutathione half-life in the cultured human lens. Exp Eye Res 53:205–212
Article
PubMed
CAS
Google Scholar
Rebrin I, Kamzalov S, Sohal RS (2003) Effects of age and caloric restriction on glutathione redox status in mice. Free Radic Biol Med 35:626–635
Article
PubMed
CAS
Google Scholar
Rivera F, Urbanavicius J, Gervaz E, Morquio A, Dajas F (2004) Some aspects of the in vivo neuroprotective capacity of flavonoids: bioavailability and structure–activity relationship. Neurotox Res 6:543–553
Article
PubMed
Google Scholar
Rock RB, Peterson PK (2006) Microglia as a pharmacological target in infectious and inflammatory diseases on the brain. J Neuroimmune Pharmacol 1:117–126
Article
PubMed
Google Scholar
Ross JA, Kasum CM (2002) Dietary flavonoids: bioavailability, metabolic effects, and safety. Annu Rev Nutr 22:19–34
Article
PubMed
CAS
Google Scholar
Sagara Y, Vahnnasy J, Maher P (2004) Induction of PC12 cell differentiation by flavonoids is dependent upon extracellular signal-regulated kinase activation. J Neurochem 90:1144–1155
Article
PubMed
CAS
Google Scholar
Sandhu SK, Kaur G (2002) Alterations in oxidative stress scavenger system in aging rat brain and lymphocytes. Biogerontology 3:161–173
Article
PubMed
CAS
Google Scholar
Sato H, Tamba M, Ishii T, Bannai S (1999) Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins. J Biol Chem 274:11455–11458
Article
PubMed
CAS
Google Scholar
Sawada M, Sawada H, Nagatsu T (2008) Effects of aging on neuroprotective and neurotoxic properties of microglia in neurodegenerative diseases. Neurodegener Dis 5:254–256
Article
PubMed
CAS
Google Scholar
Shia C-S, Tsai S-Y, Kuo S-C, Hou Y-C, Chao P-DL (2009) Metabolism and pharmacokinetics of 3, 3′, 4′, 7-tetrahydroxyflavone (fisetin), 5-hydroxyflavone and 7-hydroxyflavone and antihemolysis effects of fisetin and its serum metabolites. J Agric Food Chem 57:83–89
Article
PubMed
CAS
Google Scholar
Shukitt-Hale B, Carey AN, Jenkins D, Rabin BM, Joseph J (2007) Beneficial effects of fruit extracts on neuronal function and behavior in a rodent model of accelerated aging. Neurobiol Aging 28:1187–1194
Article
PubMed
CAS
Google Scholar
Stevenson DE, Cooney JM, Jensen DJ, Wibisono R, Adaim A, Skinner MA, Zhang J (2008) Comparison of enzymically glucuronidated flavonoids with flavonoid aglycones in an in vitro cellular model of oxidative stress protection. In Vitro Cell Dev Biol Anim (Epub)
Stolzing A, Widmer R, Jung T, Voss P, Grune T (2006) Tocopherol-mediated modulation of age-related changes in microglial cells: turnover of extracellular oxidized material. Free Radic Biol Med 40:2126–2135
Article
PubMed
CAS
Google Scholar
Suh JH, Shenvi SV, Dixon BM, Liu H, Jaiswal AK, Liu R-M, Hagen TM (2004) Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. Proc Natl Acad Sci USA 101:3381–3386
Article
PubMed
CAS
Google Scholar
Sung B, Pandey MK, Aggarwal BB (2007) Fisetin, an inhibitor of cyclin-dependent kinase 6, down-regulates nuclear factor-kB-regulated cell proliferation, antiapoptotic and metastatic gene products through the suppression of TAK-1 and receptor-interacting protein-regulated IkBa kinase activation. Mol Pharmacol 71:1703–1714
Article
PubMed
CAS
Google Scholar
Tan S, Schubert D, Maher P (2001) Oxytosis: a novel form of programmed cell death. Curr Top Med Chem 1:497–506
Article
PubMed
CAS
Google Scholar
Torreilles F, Salman-Tabcheh S, Guerin M, Torreilles J (1999) Neurodegenerative disorders: the role of peroxynitrite. Brain Res Brain Res Rev 30:153–163
Article
PubMed
CAS
Google Scholar
Tully T, Bourtchouladze R, Scott R, Tallman J (2003) Targeting the CREB pathway for memory enhancers. Nat Rev Drug Discov 2:267–277
Article
PubMed
CAS
Google Scholar
Valerio LG, Kepa JK, Pickwell GV, Quattrochi LC (2001) Induction of human NAD(P)H:quinone oxidoreductase (NQO1) gene expression by the flavonol quercetin. Toxicol Lett 119:49–57
Article
PubMed
CAS
Google Scholar
van Acker SABE, van den Berg D-J, Tromp MNJL, Griffioen DH, van Bennekom WP, van der Vijgh WJF, Bast A (1996) Structural aspects of antioxidant activity of flavonoids. Free Radic Biol Med 20:331–342
Article
PubMed
Google Scholar
Vorhees CV, Williams MT (2006) Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nat Protoc 1:848–858
Article
PubMed
Google Scholar
Wang L, Tu Y-C, Lian T-W, Hung J-T, Yen J-H, Wu M-J (2006) Distinctive antioxidant and antiinflammatory effects of flavonols. J Agric Food Chem 54:9798–9804
Article
PubMed
CAS
Google Scholar
Wang Q, Rager JD, Weinstein K, Kardos PS, Dobson GL, Li J, Hidalgo IJ (2005) Evaluation of the MDR-MDCK cell line as a permeability screen for the blood brain barrier. Int J Pharm 288:349–359
Article
PubMed
CAS
Google Scholar
Yankner BA, Lu T, Loerch P (2008) The aging brain. Annu Rev Pathol Mech Dis 3:41–66
Article
CAS
Google Scholar
Zeng B-Y, Medhurst AD, Jackson M, Rose S, Jenner P (2005) Proteasomal activity in brain differs between species and brain regions and changes with age. Mech Ageing Dev 126:760–766
Article
PubMed
CAS
Google Scholar
Zheng LT, Ock J, Kwon B-M, Suk K (2008) Suppressive effects of flavonoid fisetin on lipopolysaccharide-induced microglial activation and neurotoxicity. Int Immunopharmacol 8:484–494
Article
PubMed
CAS
Google Scholar