Genetic polymorphisms influence runners’ responses to the dietary ingestion of antioxidant supplementation based on pequi oil (Caryocar brasiliense Camb.): a before-after study

Table 3 Distribution of Haptoglobin (Hp), MnSOD, CAT, GPx-1, ACE, GSTM1, GSTT1, CK NcoI, CK TaqI, CRP G1059C, MTHFR C677T and MTHFR A1298C allele frequencies, genetic diversity parameters, genotype frequencies, and Hardy–Weinberg equilibrium data for chi-square (χ²) test

Genetic Markers	Allele frequencies		Heterozygosity-observed (H _o)	Heterozygosity-expected (H _e)	F_IS (Inbreeding coefficient)	Genotypes	Genotype frequencies	Number of observed individuals	Number of expected individuals	HWE test (P values)
Hp*	Hp^*1F	0.176	0.504	0.617	+0.1831	1F-1F	0.064	8	3.87	0.0117
						1F-1S	0.064	8	14.61
	Hp^*1S	0.332				1S-1S	0.160	20	13.78
						1F-2	0.160	20	21.65
	Hp^*2	0.492				1S-2	0.280	35	40.84
						2-2	0.272	34	30.25
MnSOD*	Val	0.568	0.800	0.491	−0.6293	Val/Val	0.168	21	40.33	0.0000
	Ala	0.432				Val/Ala	0.800	100	61.34
						Ala/Ala	0.032	4	23.33
CAT	A	0.396	0.424	0.478	+0.1130	AA	0.184	23	19.60	0.3173
	T	0.604				AT	0.424	53	59.80
						TT	0.392	49	45.60
GPx-1	Pro	0.688	0.400	0.429	+0.0676	Pro/Pro	0.488	61	59.17	0.4458
	Leu	0.312				Pro/Leu	0.400	50	53.66
						Leu/Leu	0.112	14	12.17
ACE	D	0.604	0.488	0.478	−0.0209	DD	0.360	45	45.60	0.8225
	I	0.396				ID	0.488	61	59.80
						II	0.152	19	19.60
GSTM1*	Null	0.648	–	–	–	Null	0.648	81	52.49	0.0000
	Present	0.352				Non-null	0.352	44	72.51
GSTT1*	Null	0.136	–	–	–	Null	0.136	17	2.31	0.0000
	Present	0.864				Non-null	0.864	108	122.69
CK NcoI	A	0.720	0.448	0.403	−0.1117	AA	0.496	62	64.80	0.2141
	G	0.280				AG	0.448	56	50.40
						GG	0.056	7	9.80
CK TaqI	1	0.336	0.480	0.446	−0.0762	1-1	0.096	12	14.11	0.5479
	2	0.664				1-2	0.480	60	55.78
						2-2	0.424	53	55.11
CRP G1059C	G	0.948	0.104	0.099	−0.0508	GG	0.896	112	112.34	0.5394
	C	0.052				GC	0.104	13	12.32
MTHFR C677T	C	0.672	0.400	0.441	+0.0930	CC	0.472	59	56.45	0.3008
	T	0.328				CT	0.400	50	55.10
						TT	0.128	16	13.45
MTHFR A1298C	A	0.796	0.376	0.325	−0.1569	AA	0.608	76	79.20	0.0779
	C	0.204				AC	0.376	47	40.60
						CC	0.016	2	5.20

* P < 0.05 indicates deviation from Hardy–Weinberg equilibrium, appropriate to a heterozygote deficit for Hp locus (p = 0.0012) and a heterozygote excess for MnSOD locus (P = 0.0000). P values were generated using statistical program Genepopweb version 4.0 (http://genepop.curtin.edu.au). For GSTM1 and GSTT1, genotypes were considerate as follows: Null = −/−; Non-null = +/+ and ±

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