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  1. Review

    Food components and contaminants as (anti)androgenic molecules

    Androgens, the main male sex steroids, are the critical factors responsible for the development of the male phenotype during embryogenesis and for the achievement of sexual maturation and puberty. In adulthood...

    Daniele Marcoccia, Marco Pellegrini, Marco Fiocchetti, Stefano Lorenzetti and Maria Marino

    Genes & Nutrition 2017 12:6

    Published on: 16 February 2017

  2. Research

    The impact of micronutrient status on health: correlation network analysis to understand the role of micronutrients in metabolic-inflammatory processes regulating homeostasis and phenotypic flexibility

    Vitamins and carotenoids are key micronutrients facilitating the maintenance of health, as evidenced by the increased risk of disease with low intake. Optimal phenotypic flexibility, i.e., the ability to respo...

    Tim J. van den Broek, Bas H. A. Kremer, Marisa Marcondes Rezende, Femke P. M. Hoevenaars, Peter Weber, Ulrich Hoeller, Ben van Ommen and Suzan Wopereis

    Genes & Nutrition 2017 12:5

    Published on: 8 February 2017

  3. Research

    A porcine gluteus medius muscle genome-wide transcriptome analysis: dietary effects of omega-6 and omega-3 fatty acids on biological mechanisms

    The level of omega-6 and omega-3 polyunsaturated fatty acids can affect many cellular systems and function via nuclear receptors or the bioactive lipid regulation of gene expression. The objective of this stud...

    Magdalena Ogłuszka, Agnieszka Szostak, Marinus F. W. te Pas, Ewa Poławska, Paweł Urbański, Tadeusz Blicharski, Chandra S. Pareek, Edyta Juszczuk-Kubiak, Jenelle R. Dunkelberger, Jarosław O. Horbańczuk and Mariusz Pierzchała

    Genes & Nutrition 2017 12:4

    Published on: 31 January 2017

  4. Editorial

    Propelling the paradigm shift from reductionism to systems nutrition

    The complex physiology of living organisms represents a challenge for mechanistic understanding of the action of dietary bioactives in the human body and of their possible role in health and disease. Animal, c...

    Jim Kaput, Giuditta Perozzi, Marijana Radonjic and Fabio Virgili

    Genes & Nutrition 2017 12:3

    Published on: 25 January 2017

  5. Research

    Effect of high carbohydrate diet on elongase and desaturase activity and accompanying gene expression in rat’s liver

    Hepatic fatty acids (FAs) are modified through different metabolic pathways including elongation and desaturation. These processes are catalyzed by elongases and desaturases, respectively. Glucose, by transcri...

    Jagoda Drąg, Anna Goździalska, Małgorzata Knapik-Czajka, Anna Gawędzka, Katarzyna Gawlik and Jerzy Jaśkiewicz

    Genes & Nutrition 2017 12:2

    Published on: 25 January 2017

  6. Research

    Protein-restricted diet during pregnancy after insemination alters behavioral phenotypes of the progeny

    Epidemiological studies suggest that hyponutrition during the fetal period increases the risk of mental disorders such as attention deficit hyperactivity disorder and autism-spectrum disorder, which has been e...

    Tamio Furuse, Kunio Miyake, Takashi Kohda, Hideki Kaneda, Takae Hirasawa, Ikuko Yamada, Tomoko Kushida, Misho Kashimura, Kimio Kobayashi, Fumitoshi Ishino, Takeo Kubota and Shigeharu Wakana

    Genes & Nutrition 2017 12:1

    Published on: 19 January 2017

  7. Research

    Tocotrienols induce endoplasmic reticulum stress and apoptosis in cervical cancer cells

    We have previously reported that γ- and δ-tocotrienols (γ- and δ-T3) induce gene expression and apoptosis in human breast cancer cells (MDA-MB-231 and MCF-7). This effect is mediated, at least in part, by a sp...

    Raffaella Comitato, Barbara Guantario, Guido Leoni, Kalanithi Nesaretnam, Maria Beatrice Ronci, Raffaella Canali and Fabio Virgili

    Genes & Nutrition 2016 11:32

    Published on: 23 December 2016

  8. Research

    Time-course microarray analysis for identifying candidate genes involved in obesity-associated pathological changes in the mouse colon

    Obesity is known to increase the risk of colorectal cancer. However, mechanisms underlying the pathogenesis of obesity-induced colorectal cancer are not completely understood. The purposes of this study were t...

    Yun Jung Bae, Sung-Eun Kim, Seong Yeon Hong, Taesun Park, Sang Gyu Lee, Myung-Sook Choi and Mi-Kyung Sung

    Genes & Nutrition 2016 11:30

    Published on: 22 November 2016

  9. Research

    Hepatic transcriptome implications for palm fruit juice deterrence of type 2 diabetes mellitus in young male Nile rats

    The Nile rat (NR, Arvicanthis niloticus) is a model of carbohydrate-induced type 2 diabetes mellitus (T2DM) and the metabolic syndrome. A previous study found that palm fruit juice (PFJ) delayed or prevented diab...

    Soon-Sen Leow, Julia Bolsinger, Andrzej Pronczuk, K. C. Hayes and Ravigadevi Sambanthamurthi

    Genes & Nutrition 2016 11:29

    Published on: 22 October 2016

  10. Research

    The impact of MTHFR 677C → T risk knowledge on changes in folate intake: findings from the Food4Me study

    It is hypothesised that individuals with knowledge of their genetic risk are more likely to make health-promoting dietary and lifestyle changes. The present study aims to test this hypothesis using data from t...

    Clare B. O’Donovan, Marianne C. Walsh, Hannah Forster, Clara Woolhead, Carlos Celis-Morales, Rosalind Fallaize, Anna L. Macready, Cyril F. M. Marsaux, Santiago Navas-Carretero, Rodrigo San-Cristobal, Silvia Kolossa, Christina Mavrogianni, Christina P. Lambrinou, George Moschonis, Magdalena Godlewska, Agnieszka Surwillo…

    Genes & Nutrition 2016 11:25

    Published on: 29 September 2016

  11. Research

    Linkage and association analysis of circulating vitamin D and parathyroid hormone identifies novel loci in Alaska Native Yup’ik people

    Vitamin D deficiency is a well-documented public health issue with both genetic and environmental determinants. Populations living at far northern latitudes are vulnerable to vitamin D deficiency and its healt...

    Stella Aslibekyan, Laura K. Vaughan, Howard W. Wiener, Bertha A. Hidalgo, Dominick J. Lemas, Diane M. O’Brien, Scarlett E. Hopkins, Kimber L. Stanhope, Peter J. Havel, Kenneth E. Thummel, Bert B. Boyer and Hemant K. Tiwari

    Genes & Nutrition 2016 11:23

    Published on: 2 August 2016

  12. Research

    Fatty acid extract from CLA-enriched egg yolks can mediate transcriptome reprogramming of MCF-7 cancer cells to prevent their growth and proliferation

    Our previous study showed that fatty acids extract obtained from CLA-enriched egg yolks (EFA-CLA) suppressed the viability of MCF-7 cancer cell line more effectively than extract from non-enriched egg yolks (E...

    Aneta A. Koronowicz, Paula Banks, Dominik Domagała, Adam Master, Teresa Leszczyńska, Ewelina Piasna, Mariola Marynowska and Piotr Laidler

    Genes & Nutrition 2016 11:22

    Published on: 27 July 2016

    The Erratum to this article has been published in Genes & Nutrition 2016 11:24

  13. Research

    Coordinated regulation of hepatic and adipose tissue transcriptomes by the oral administration of an amino acid mixture simulating the larval saliva of Vespa species

    VAAM is an amino acid mixture that simulates the composition of Vespa larval saliva. VAAM enhanced physical endurance of mice and have been used by athletes as a supplementary drink before exercise. However, ther...

    Fumika Shinozaki, Takashi Abe, Asuka Kamei, Yuki Watanabe, Akihito Yasuoka, Kosuke Shimada, Kaori Kondo, Soichi Arai, Kota Kumagai, Takashi Kondo and Keiko Abe

    Genes & Nutrition 2016 11:21

    Published on: 11 July 2016

  14. Research

    Genetic susceptibility to dyslipidemia and incidence of cardiovascular disease depending on a diet quality index in the Malmö Diet and Cancer cohort

    By taking diet quality into account, we may clarify the relationship between genetically elevated triglycerides (TG) and low-density lipoprotein-cholesterol (LDL-C), and better understand the inconsistent resu...

    Sophie Hellstrand, Ulrika Ericson, Christina-Alexandra Schulz, Isabel Drake, Bo Gullberg, Bo Hedblad, Gunnar Engström, Marju Orho-Melander and Emily Sonestedt

    Genes & Nutrition 2016 11:20

    Published on: 7 July 2016

  15. Research

    Metallothioneins 1 and 2, but not 3, are regulated by nutritional status in rat white adipose tissue

    Cumulating evidence underlines the role of adipose tissue metallothionein (MT) in the development of obesity and type 2 diabetes. Fasting/refeeding was shown to affect MT gene expression in the rodent liver. T...

    Sylwia Szrok, Ewa Stelmanska, Jacek Turyn, Aleksandra Bielicka-Gieldon, Tomasz Sledzinski and Julian Swierczynski

    Genes & Nutrition 2016 11:18

    Published on: 23 June 2016

  16. Research

    Moderately decreased maternal dietary energy intake during pregnancy reduces fetal skeletal muscle mitochondrial biogenesis in the pigs

    Mitochondria are of major importance in oocyte and early embryo, playing a key role in maintaining energy homeostasis. Epidemiological findings indicate that maternal undernutrition-induced mitochondrial dysfu...

    Tiande Zou, Bing Yu, Jie Yu, Xiangbing Mao, Ping Zheng, Jun He, Zhiqing Huang, Yue Liu and Daiwen Chen

    Genes & Nutrition 2016 11:19

    Published on: 23 June 2016

  17. Research Paper

    The PBMC transcriptome profile after intake of oxidized versus high-quality fish oil: an explorative study in healthy subjects

    Marine long-chain polyunsaturated fatty acids are susceptible to oxidation, generating a range of different oxidation products with suggested negative health effects. The aim of the present study was to utiliz...

    Mari C. W. Myhrstad, Inger Ottestad, Clara-Cecilie Günther, Einar Ryeng, Marit Holden, Astrid Nilsson, Kirsti W. Brønner, Achim Kohler, Grethe I. A. Borge, Kirsten B. Holven and Stine M. Ulven

    Genes & Nutrition 2016 11:16

    Published on: 31 May 2016

  18. Research

    Ancient pathogen-driven adaptation triggers increased susceptibility to non-celiac wheat sensitivity in present-day European populations

    Non-celiac wheat sensitivity is an emerging wheat-related syndrome showing peak prevalence in Western populations. Recent studies hypothesize that new gliadin alleles introduced in the human diet by replacemen...

    Marco Sazzini, Sara De Fanti, Anna Cherubini, Andrea Quagliariello, Giuseppe Profiti, Pier Luigi Martelli, Rita Casadio, Chiara Ricci, Massimo Campieri, Alberto Lanzini, Umberto Volta, Giacomo Caio, Claudio Franceschi, Enzo Spisni and Donata Luiselli

    Genes & Nutrition 2016 11:15

    Published on: 23 May 2016

  19. Research

    Liver-specific NG37 overexpression leads to diet-dependent fatty liver disease accompanied by cardiac dysfunction

    Environmental factors are well-known causes of diseases. However, aside from a handful of risk indicators, genes’ encoding susceptibility to chronic illnesses and their associated environmental triggers are la...

    Xin Zhou, MengMeng Xu, Liyang Wang, Yulian Mu, Rui Feng, Zhilong Dong, Yuexin Pan, Xunzhang Chen, Yongfeng Liu, Shangen Zheng, Donald D. Anthony, Jianjie Ma, Williams B. Isaacs and Xuehong Xu

    Genes & Nutrition 2016 11:14

    Published on: 21 May 2016

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