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  2. Research

    The impact of MTHFR 677C → T risk knowledge on changes in folate intake: findings from the Food4Me study

    It is hypothesised that individuals with knowledge of their genetic risk are more likely to make health-promoting dietary and lifestyle changes. The present study aims to test this hypothesis using data from t...

    Clare B. O’Donovan, Marianne C. Walsh, Hannah Forster, Clara Woolhead, Carlos Celis-Morales, Rosalind Fallaize, Anna L. Macready, Cyril F. M. Marsaux, Santiago Navas-Carretero, Rodrigo San-Cristobal, Silvia Kolossa, Christina Mavrogianni, Christina P. Lambrinou, George Moschonis, Magdalena Godlewska, Agnieszka Surwillo…

    Genes & Nutrition 2016 11:25

    Published on: 29 September 2016

  4. Research

    Linkage and association analysis of circulating vitamin D and parathyroid hormone identifies novel loci in Alaska Native Yup’ik people

    Vitamin D deficiency is a well-documented public health issue with both genetic and environmental determinants. Populations living at far northern latitudes are vulnerable to vitamin D deficiency and its healt...

    Stella Aslibekyan, Laura K. Vaughan, Howard W. Wiener, Bertha A. Hidalgo, Dominick J. Lemas, Diane M. O’Brien, Scarlett E. Hopkins, Kimber L. Stanhope, Peter J. Havel, Kenneth E. Thummel, Bert B. Boyer and Hemant K. Tiwari

    Genes & Nutrition 2016 11:23

    Published on: 2 August 2016

  5. Research

    Fatty acid extract from CLA-enriched egg yolks can mediate transcriptome reprogramming of MCF-7 cancer cells to prevent their growth and proliferation

    Our previous study showed that fatty acids extract obtained from CLA-enriched egg yolks (EFA-CLA) suppressed the viability of MCF-7 cancer cell line more effectively than extract from non-enriched egg yolks (E...

    Aneta A. Koronowicz, Paula Banks, Dominik Domagała, Adam Master, Teresa Leszczyńska, Ewelina Piasna, Mariola Marynowska and Piotr Laidler

    Genes & Nutrition 2016 11:22

    Published on: 27 July 2016

    The Erratum to this article has been published in Genes & Nutrition 2016 11:24

  6. Research

    Coordinated regulation of hepatic and adipose tissue transcriptomes by the oral administration of an amino acid mixture simulating the larval saliva of Vespa species

    VAAM is an amino acid mixture that simulates the composition of Vespa larval saliva. VAAM enhanced physical endurance of mice and have been used by athletes as a supplementary drink before exercise. However, ther...

    Fumika Shinozaki, Takashi Abe, Asuka Kamei, Yuki Watanabe, Akihito Yasuoka, Kosuke Shimada, Kaori Kondo, Soichi Arai, Kota Kumagai, Takashi Kondo and Keiko Abe

    Genes & Nutrition 2016 11:21

    Published on: 11 July 2016

  7. Research

    Genetic susceptibility to dyslipidemia and incidence of cardiovascular disease depending on a diet quality index in the Malmö Diet and Cancer cohort

    By taking diet quality into account, we may clarify the relationship between genetically elevated triglycerides (TG) and low-density lipoprotein-cholesterol (LDL-C), and better understand the inconsistent resu...

    Sophie Hellstrand, Ulrika Ericson, Christina-Alexandra Schulz, Isabel Drake, Bo Gullberg, Bo Hedblad, Gunnar Engström, Marju Orho-Melander and Emily Sonestedt

    Genes & Nutrition 2016 11:20

    Published on: 7 July 2016

  8. Research

    Metallothioneins 1 and 2, but not 3, are regulated by nutritional status in rat white adipose tissue

    Cumulating evidence underlines the role of adipose tissue metallothionein (MT) in the development of obesity and type 2 diabetes. Fasting/refeeding was shown to affect MT gene expression in the rodent liver. T...

    Sylwia Szrok, Ewa Stelmanska, Jacek Turyn, Aleksandra Bielicka-Gieldon, Tomasz Sledzinski and Julian Swierczynski

    Genes & Nutrition 2016 11:18

    Published on: 23 June 2016

  9. Research

    Moderately decreased maternal dietary energy intake during pregnancy reduces fetal skeletal muscle mitochondrial biogenesis in the pigs

    Mitochondria are of major importance in oocyte and early embryo, playing a key role in maintaining energy homeostasis. Epidemiological findings indicate that maternal undernutrition-induced mitochondrial dysfu...

    Tiande Zou, Bing Yu, Jie Yu, Xiangbing Mao, Ping Zheng, Jun He, Zhiqing Huang, Yue Liu and Daiwen Chen

    Genes & Nutrition 2016 11:19

    Published on: 23 June 2016

  11. Research Paper

    The PBMC transcriptome profile after intake of oxidized versus high-quality fish oil: an explorative study in healthy subjects

    Marine long-chain polyunsaturated fatty acids are susceptible to oxidation, generating a range of different oxidation products with suggested negative health effects. The aim of the present study was to utiliz...

    Mari C. W. Myhrstad, Inger Ottestad, Clara-Cecilie Günther, Einar Ryeng, Marit Holden, Astrid Nilsson, Kirsti W. Brønner, Achim Kohler, Grethe I. A. Borge, Kirsten B. Holven and Stine M. Ulven

    Genes & Nutrition 2016 11:16

    Published on: 31 May 2016

  12. Research

    Ancient pathogen-driven adaptation triggers increased susceptibility to non-celiac wheat sensitivity in present-day European populations

    Non-celiac wheat sensitivity is an emerging wheat-related syndrome showing peak prevalence in Western populations. Recent studies hypothesize that new gliadin alleles introduced in the human diet by replacemen...

    Marco Sazzini, Sara De Fanti, Anna Cherubini, Andrea Quagliariello, Giuseppe Profiti, Pier Luigi Martelli, Rita Casadio, Chiara Ricci, Massimo Campieri, Alberto Lanzini, Umberto Volta, Giacomo Caio, Claudio Franceschi, Enzo Spisni and Donata Luiselli

    Genes & Nutrition 2016 11:15

    Published on: 23 May 2016

  13. Research

    Liver-specific NG37 overexpression leads to diet-dependent fatty liver disease accompanied by cardiac dysfunction

    Environmental factors are well-known causes of diseases. However, aside from a handful of risk indicators, genes’ encoding susceptibility to chronic illnesses and their associated environmental triggers are la...

    Xin Zhou, MengMeng Xu, Liyang Wang, Yulian Mu, Rui Feng, Zhilong Dong, Yuexin Pan, Xunzhang Chen, Yongfeng Liu, Shangen Zheng, Donald D. Anthony, Jianjie Ma, Williams B. Isaacs and Xuehong Xu

    Genes & Nutrition 2016 11:14

    Published on: 21 May 2016

  14. Research

    Differences in genome-wide gene expression response in peripheral blood mononuclear cells between young and old men upon caloric restriction

    Caloric restriction (CR) is considered to increase lifespan and to prevent various age-related diseases in different nonhuman organisms. Only a limited number of CR studies have been performed on humans, and r...

    I. P. G. Van Bussel, A. Jolink-Stoppelenburg, C. P. G. M. De Groot, M. R. Müller and L. A. Afman

    Genes & Nutrition 2016 11:13

    Published on: 6 May 2016

  16. Review

    Biomarkers for nutrient intake with focus on alternative sampling techniques

    Biomarkers of nutrient intake or nutrient status are important objective measures of foods/nutrients as one of the most important environmental factors people are exposed to. It is very difficult to obtain acc...

    T. Holen, F. Norheim, T. E. Gundersen, P. Mitry, J. Linseisen, P. O. Iversen and C. A. Drevon

    Genes & Nutrition 2016 11:12

    Published on: 16 April 2016

  17. Research

    Several type 2 diabetes-associated variants in genes annotated to WNT signaling interact with dietary fiber in relation to incidence of type 2 diabetes

    TCF7L2 is a central transcription factor in the canonical wingless-type MMTV integration site (WNT) signaling pathway, and genetic variants in TCF7L2 have been found to interact with dietary fiber intake on type ...

    George Hindy, Inês G. Mollet, Gull Rukh, Ulrika Ericson and Marju Orho-Melander

    Genes & Nutrition 2016 11:6

    Published on: 21 March 2016

  18. Research

    Circulating microRNAs are deregulated in overweight/obese children: preliminary results of the I.Family study

    MicroRNAs (miRNAs) are small non-coding RNAs involved in the modulation of gene expression and in the control of numerous cell functions. Alterations of miRNA patterns frequently occur in cancer and metabolic ...

    Giuseppe Iacomino, Paola Russo, Ilaria Stillitano, Fabio Lauria, Pasquale Marena, Wolfgang Ahrens, Pasquale De Luca and Alfonso Siani

    Genes & Nutrition 2016 11:7

    Published on: 21 March 2016

  22. Research Paper

    Effect of a diet enriched with omega-6 and omega-3 fatty acids on the pig liver transcriptome

    The optimal ratio of omega-6 to omega-3 polyunsaturated fatty acids (PUFAs) is important for keeping the homeostasis of biological processes and metabolism, yet the underlying biological mechanism is poorly un...

    Agnieszka Szostak, Magdalena Ogłuszka, Marinus F. W. te Pas, Ewa Poławska, Paweł Urbański, Edyta Juszczuk-Kubiak, Tadeusz Blicharski, Chandra Shekhar Pareek, Jenelle R. Dunkelberger, Jarosław O. Horbańczuk and Mariusz Pierzchała

    Genes & Nutrition 2016 11:9

    Published on: 17 March 2016

  24. Research Paper

    Comparative anti-inflammatory and lipid-normalizing effects of metformin and omega-3 fatty acids through modulation of transcription factors in diabetic rats

    Emerging evidence suggests beneficial effects of omega-3 fatty acids on diabetic complications. The present study compared the progressive effects of metformin and flax/fish oil on lipid metabolism, inflammato...

    Abhijit Ghadge, Abhay Harsulkar, Manjiri Karandikar, Vijaya Pandit and Aniket Kuvalekar

    Genes & Nutrition 2016 11:10

    Published on: 17 March 2016

  25. Research

    Vitamin A deficiency modulates iron metabolism independent of hemojuvelin (Hfe2) and bone morphogenetic protein 6 (Bmp6) transcript levels

    Considering that vitamin A deficiency modulates hepcidin expression and consequently affects iron metabolism, we evaluated the effect of vitamin A deficiency in the expression of genes involved in the hemojuve...

    Juliana Frossard Ribeiro Mendes, Egle Machado de Almeida Siqueira, João Gabriel Marques de Brito e Silva and Sandra Fernandes Arruda

    Genes & Nutrition 2016 11:1

    Published on: 17 March 2016

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