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  1. The genes contributing to childhood obesity are categorized into three different types based on distinct genetic and phenotypic characteristics. These types of childhood obesity are represented by rare monogen...

    Authors: William S. Garver, Sara B. Newman, Diana M. Gonzales-Pacheco, Joseph J. Castillo, David Jelinek, Randall A. Heidenreich and Robert A. Orlando
    Citation: Genes & Nutrition 2013 8:339
  2. This article discusses the prospects and limitations of the scientific basis for offering personalized nutrition advice based upon individual genetic information. Two divergent scientific positions are present...

    Authors: Ulf Görman, John C. Mathers, Keith A. Grimaldi, Jennie Ahlgren and Karin Nordström
    Citation: Genes & Nutrition 2013 8:338
  3. Studies have demonstrated large within-population heterogeneity in plasma triacylglycerol (TG) response to n-3 PUFA supplementation. The objective of the study was to compare metabolomic and transcriptomic pro...

    Authors: Iwona Rudkowska, Ann-Marie Paradis, Elisabeth Thifault, Pierre Julien, Olivier Barbier, Patrick Couture, Simone Lemieux and Marie-Claude Vohl
    Citation: Genes & Nutrition 2012 8:328
  4. The SERPINE1 (serpin peptidase inhibitor, clade E, member 1) gene, better known by its previous symbol PAI-1 (plasminogen activator inhibitor 1), has been associated with cardiovascular phenotypes with differi...

    Authors: Mercedes Sotos-Prieto, Marisa Guillén, Olga Portolés, José V. Sorlí, José I. González, Eva M. Asensio and Dolores Corella
    Citation: Genes & Nutrition 2012 8:327
  5. Dietary omega-3 fatty acids have been demonstrated to have positive physiological effects on lipid metabolism, cardiovascular system and insulin resistance. Type-2 diabetes (T2DM) is known for perturbations in...

    Authors: Prasad P. Devarshi, Nivedita M. Jangale, Arvindkumar E. Ghule, Subhash L. Bodhankar and Abhay M. Harsulkar
    Citation: Genes & Nutrition 2012 8:326
  6. Monounsaturated fatty acids (MUFA) have been viewed as either beneficial or neutral with respect to health; however, recent evidence suggests that MUFA may be associated with obesity and cardiovascular disease...

    Authors: Kristin A. Marks, Alex P. Kitson and Ken D. Stark
    Citation: Genes & Nutrition 2012 8:325
  7. Prolonged high-fat diet leads to the development of obesity and multiple comorbidities including non-alcoholic steatohepatitis (NASH), but the underlying molecular basis is not fully understood. We combine mol...

    Authors: Hea-Young Oh, Su-kyung Shin, Hyoung-Sam Heo, Ji-Sook Ahn, Eun-Young Kwon, Jung Han Yoon Park, Yun-young Cho, Hae-Jin Park, Mi-Kyung Lee, Eun Jung Kim, Un-Ju Jung, Robin A. McGregor, Cheol-Goo Hur and Myung-Sook Choi
    Citation: Genes & Nutrition 2012 8:322
  8. This commentary is a face-to-face debate between two almost opposite positions regarding the application of genetic engineering in agriculture and food production. Seven questions on the potential benefits of ...

    Authors: M. Buiatti, P. Christou and G. Pastore
    Citation: Genes & Nutrition 2012 8:316
  9. Genome-wide association studies (GWASs) have become a very important tool to address the genetic origin of phenotypic variability, in particular associated with diseases. Nevertheless, these types of studies p...

    Authors: Ivan Montoliu, Ulrich Genick, Mirko Ledda, Sebastiano Collino, François-Pierre Martin, Johannes le Coutre and Serge Rezzi
    Citation: Genes & Nutrition 2012 8:313
  10. The relationship between genetic and the environment represents a pathway to better understand individual variations in nutrition intake and food preferences. However, the present literature is weakened somewh...

    Authors: Jianghong Liu, Catherine Tuvblad, Adrian Raine and Laura Baker
    Citation: Genes & Nutrition 2012 8:320
  11. Little is known about the role of folate and polymorphisms associated with folate metabolism on prostate cancer risk in populations of African origin. We examined the relationship between serum folate and pros...

    Authors: Maria D. Jackson, Marshall K. Tulloch-Reid, Norma McFarlane-Anderson, Alexis Watson, Vestra Seers, Franklyn I. Bennett, Brian Egleston and Camille Ragin
    Citation: Genes & Nutrition 2012 8:321
  12. Endothelial hyperpermeability induced by hyperglycemia is the initial step in the development of atherosclerosis, one of the most serious cardiovascular complications in diabetes. In the present study, we inve...

    Authors: Chong Tian, Rui Zhang, Xiaolei Ye, Changhui Zhang, Xin Jin, Yukio Yamori, Liping Hao, Xiufa Sun and Chenjiang Ying
    Citation: Genes & Nutrition 2012 8:319
  13. Folic acid is an essential nutrient that is required for one-carbon biosynthetic processes and for methylation of biomolecules. Deficiency of this micronutrient leads to disturbances in normal physiology of ce...

    Authors: Nissar Ahmad Wani, Ritambhara Nada, Krishan Lal Khanduja and Jyotdeep Kaur
    Citation: Genes & Nutrition 2012 8:318
  14. In the past 20 years, the scientific community has faced a great development in different fields due to the development of high-throughput, omics technologies. Starting from the four major types of omics measurem...

    Authors: Francesco Capozzi and Alessandra Bordoni
    Citation: Genes & Nutrition 2012 8:310
  15. Malnutrition is a prevalent and entrenched global socioeconomic challenge that reflects the combined impact of poverty, poor access to food, inefficient food distribution infrastructure, and an over-reliance o...

    Authors: Eduard Pérez-Massot, Raviraj Banakar, Sonia Gómez-Galera, Uxue Zorrilla-López, Georgina Sanahuja, Gemma Arjó, Bruna Miralpeix, Evangelia Vamvaka, Gemma Farré, Sol Maiam Rivera, Svetlana Dashevskaya, Judit Berman, Maite Sabalza, Dawei Yuan, Chao Bai, Ludovic Bassie…
    Citation: Genes & Nutrition 2012 8:315
  16. In this work, the effect of rosemary extracts rich on polyphenols obtained using pressurized fluids was investigated on the gene expression of human SW480 and HT29 colon cancer cells. The application of transc...

    Authors: Alberto Valdés, Virginia García-Cañas, Lourdes Rocamora-Reverte, Ángeles Gómez-Martínez, José Antonio Ferragut and Alejandro Cifuentes
    Citation: Genes & Nutrition 2012 8:311
  17. Folate hydrolase 1 (FOLH1) gene encodes intestinal folate hydrolase, which regulates intestinal absorption of dietary folate. Previous studies on the association between polymorphisms rs202676 and rs61886492 and ...

    Authors: Jin Guo, Hua Xie, Jianhua Wang, Huizhi Zhao, Fang Wang, Chi Liu, Li Wang, Xiaolin Lu, Yihua Bao, Jizhen Zou, Guoliang Wang, Bo Niu and Ting Zhang
    Citation: Genes & Nutrition 2012 8:309
  18. Hydrogen sulphide (H2S) is a gaseous signalling molecule that regulates blood flow and pressure. It is synthesised from cysteine via cystathionine β-synthase and cystathionine γ-lyase. We examined whether thiol p...

    Authors: Mark Lucock, Zoë Yates, Charlotte Martin, Jeong-Hwa Choi, Lyndell Boyd, Sa Tang, Nenad Naumovski, Paul Roach and Martin Veysey
    Citation: Genes & Nutrition 2012 8:317
  19. A methyl-deficient diet (MD) lacking folic acid and the associated methyl donors choline and methionine, fed to the laboratory rat during the periods of oocyte and embryo development, has been shown to program...

    Authors: Christopher A. Maloney, Susan M. Hay, Martin D. Reid, Gary Duncan, Fergus Nicol, Kevin D. Sinclair and William D. Rees
    Citation: Genes & Nutrition 2012 8:314
  20. Fish aquaculture is considered to be one of the most sustainable sources of protein for humans. Many different species are cultured worldwide, but among them, marine flatfishes comprise a group of teleosts of ...

    Authors: Joan Cerdà and Manuel Manchado
    Citation: Genes & Nutrition 2012 8:312
  21. Breast cancer is the leading cause of cancer deaths in women. Diet and lifestyle are major contributing factors to increased breast cancer risk. While mechanisms underlying dietary protection of mammary tumor ...

    Authors: John Mark P. Pabona, Bhuvanesh Dave, Ying Su, Maria Theresa E. Montales, Ben O. de Lumen, Elvira G. de Mejia, Omar M. Rahal and Rosalia C. M. Simmen
    Citation: Genes & Nutrition 2012 8:307
  22. The relationship between obesity and a single nucleotide polymorphism (SNP), rs5443 (C825T), in the guanine nucleotide binding protein beta polypeptide 3 (GNB3) gene is currently inconsistent. In this study, we a...

    Authors: Tun-Jen Hsiao, Yuchi Hwang, Can-Hong Liu, Hua-Mei Chang and Eugene Lin
    Citation: Genes & Nutrition 2012 8:304
  23. Adult-type hypolactasia (AtH or lactase non-persistence) is the physiological decline in lactase activity that manifests in majority of the world’s population after weaning. Recently, various single-nucleotide...

    Authors: Raja A. H. Kuchay, Mumtaz Anwar, Babu R. Thapa, Akhtar Mahmood and Safrun Mahmood
    Citation: Genes & Nutrition 2012 8:305
  24. Dietary polyunsaturated fatty acids (PUFAs) can be converted to prostaglandins and leukotrienes. Oxygenation of omega-6 PUFAs generally results in the production of pro-inflammatory mediators, whereas oxygenat...

    Authors: Nina Habermann, Cornelia M. Ulrich, Abbie Lundgreen, Karen W. Makar, Elizabeth M. Poole, Bette Caan, Richard Kulmacz, John Whitton, Rachel Galbraith, John D. Potter and Martha L. Slattery
    Citation: Genes & Nutrition 2012 8:302
  25. The satiating effect of fibre consumption has been related to gut hormones, such as peptide YY and leptin. These peptides may also influence cardiovascular (CVD) risk biomarkers. Nevertheless, there is wide in...

    Authors: Anna Crescenti, Rosa Solà, Rosa M. Valls, Anna Anguera and Lluís Arola
    Citation: Genes & Nutrition 2012 8:303
  26. Significant health benefits have been demonstrated for certain probiotic strains through intervention studies; however, there is a shortage of experimental evidence relative to the mechanisms of action. Here, ...

    Authors: Christine Bäuerl, Marta Llopis, María Antolín, Vicente Monedero, Manuel Mata, Manuel Zúñiga, Francisco Guarner and Gaspar Pérez Martínez
    Citation: Genes & Nutrition 2012 8:301
  27. Non-alcoholic fatty liver disease (NAFLD) is one of the first hepatic manifestations of metabolic syndrome, whose progression can lead to cirrhosis and hepatic carcinoma. Interestingly, methyl donor supplement...

    Authors: P. Cordero, A. M. Gomez-Uriz, J. Campion, F. I. Milagro and J. A. Martinez
    Citation: Genes & Nutrition 2012 8:300
  28. TGF-β is a potent pleiotropic factor that promotes small intestinal cell differentiation. The role of microRNAs in the TGF-β induction of intestinal epithelial phenotype is largely unknown. We hypothesized tha...

    Authors: Yalin Liao, Man Zhang and Bo Lönnerdal
    Citation: Genes & Nutrition 2012 8:297
  29. Insulin resistance in skeletal muscle is an early phenomenon in the pathogenesis of type 2 diabetes. Muscle is mainly responsible for insulin-stimulated glucose clearance from the bloodstream. Thus, regulation...

    Authors: Iwona Rudkowska, Hélène Jacques, S. John Weisnagel, André Marette and Marie-Claude Vohl
    Citation: Genes & Nutrition 2012 8:298
  30. Genetic factors may interact with lifestyle factors to modify obesity risk. FTO and PPARG2 are relevant obesogenes. Our aim was to explore the effect of Pro12Ala (rs1801282) of PPARG2 and rs9939609 of FTO on obes...

    Authors: Cecilia Galbete, Jon Toledo, Miguel Ángel Martínez-González, J. Alfredo Martínez, Francisco Guillén-Grima and Amelia Marti
    Citation: Genes & Nutrition 2012 8:296
  31. Fatty liver is associated with obesity and breast cancer. We used an obese rat model of mammary cancer to examine whether hepatosteatosis is modifiable by diet and associated with altered expression of hepatic...

    Authors: Reza Hakkak, Ahmed Al-Dwairi, George J. Fuchs, Soheila Korourian and Frank A. Simmen
    Citation: Genes & Nutrition 2012 7:294
  32. Equol is a daidzein (a phytoestrogen isoflavone) metabolite of gut bacteria, and the ability to produce equol varies between individuals and reduces the risks of several diseases. We tested the effects of equo...

    Authors: Kyung-Won Hong, Kwang-Pil Ko, Younjhin Ahn, Cheong-Sik Kim, Seon-Joo Park, Jae Kyung Park, Sung Soo Kim and Yeonjung Kim
    Citation: Genes & Nutrition 2012 7:292
  33. Conjugated linoleic acids (CLAs) are natural PPARγ ligands, which showed conflicting effects on metabolism in humans. We examined metabolic effects of different isomers of CLA in subjects with PPARγ2 Pro12Ala ...

    Authors: Diana Rubin, Julia Herrmann, Daniela Much, Maria Pfeuffer, C. Laue, P. Winkler, Ulf Helwig, Doris Bell, Annegret Auinger, Stephanie Darabaneanu, Andreas Ruether and Jürgen Schrezenmeir
    Citation: Genes & Nutrition 2012 7:289
  34. Evidence of enhanced oxidative stress (O.S.) and lipid peroxidation has been reported in patients with Rett syndrome (RTT), a relatively rare neurodevelopmental disorder progressing in 4-stages, and mainly cau...

    Authors: Claudio De Felice, Cinzia Signorini, Thierry Durand, Lucia Ciccoli, Silvia Leoncini, Maurizio D’Esposito, Stefania Filosa, Camille Oger, Alexandre Guy, Valérie Bultel-Poncé, Jean-Marie Galano, Alessandra Pecorelli, Laura De Felice, Giuseppe Valacchi and Joussef Hayek
    Citation: Genes & Nutrition 2012 7:285
  35. The innate immune receptor toll-like receptor 4 (TLR4) has been implicated in mediating some of the effects of dietary lipids on inflammation and type 2 diabetes (T2D). Similar to TLR4, the nucleotide-binding ...

    Authors: Cristina Cuda, Alaa Badawi, Mohamed Karmali and Ahmed El-Sohemy
    Citation: Genes & Nutrition 2012 7:287
  36. Genome-wide association studies have identified SNPs reproducibly associated with type 2 diabetes (T2D). We examined the effect of genetic predisposition to T2D on insulin sensitivity and secretion using detai...

    Authors: Celia G. Walker, Ruth J. F. Loos, Adrian P. Mander, Susan A. Jebb, Gary S. Frost, Bruce A. Griffin, Julie A. Lovegrove, Thomas A. B. Sanders and Les J. Bluck
    Citation: Genes & Nutrition 2012 7:284
  37. The fatty-acid-binding protein-2 (FABP2) gene has been proposed as a candidate gene for diabetes because the encoded protein is involved in fatty acid absorption and therefore may affect insulin sensitivity and g...

    Authors: Diana Rubin, Ulf Helwig, Maria Pfeuffer, Annegret Auinger, Andreas Ruether, Dennis Matusch, Stephanie Darabaneanu, Sandra Freitag-Wolf, Michael Nothnagel, Stefan Schreiber and Jürgen Schrezenmeir
    Citation: Genes & Nutrition 2012 7:280
  38. We examined the potential implication of skeletal muscle in the fat-lowering effect observed in mice treated with moderate doses of CLA. In experiment 1, mice fed with a standard-fat diet were orally treated w...

    Authors: Pilar Parra, Francisca Serra and Andreu Palou
    Citation: Genes & Nutrition 2012 7:279
  39. Iron deficiency (ID) remains a public health concern affecting ~25% of the world’s population. Metabolic consequences of ID include elevated plasma glucose concentrations consistent with increased reliance on ...

    Authors: McKale R. Davis, Elizabeth Rendina, Sandra K. Peterson, Edralin A. Lucas, Brenda J. Smith and Stephen L. Clarke
    Citation: Genes & Nutrition 2012 7:278
  40. Experimental replication is fundamental for practicing science. To reduce variability, it is essential to control sources of variation as much as possible. Diet is an important factor that can influence many p...

    Authors: Femke P. M. Hoevenaars, Evert M. van Schothorst, Olga Horakova, Anja Voigt, Martin Rossmeisl, Catalina Pico, Antoni Caimari, Jan Kopecky, Susanne Klaus and Jaap Keijer
    Citation: Genes & Nutrition 2012 7:262
  41. The aim of the present work was to study the effects of benfotiamine (S-benzoylthiamine O-monophosphate) on glucose and lipid metabolism and gene expression in differentiated human skeletal muscle cells (myotu...

    Authors: D. A. Fraser, N. P. Hessvik, N. Nikolić, V. Aas, K. F. Hanssen, S. K. Bøhn, G. H. Thoresen and A. C. Rustan
    Citation: Genes & Nutrition 2011 7:252

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