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  1. The presence of chemotherapy-resistant colorectal cancer stem cells (CCSCs) with KRAS mutation is thought to be one of the primary causes for treatment failure in colorectal cancer (CRC). P53, survivin, and mi...

    Authors: Mohammad Reza Sam, Mohammad Tavakoli-Mehr and Reza Safaralizadeh

    Citation: Genes & Nutrition 2018 13:8

    Content type: Research

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  2. Liver is the crucial organ as a hub for metabolic reactions. p16(INK4a) is a well-established cyclin-dependent kinase (CDK) inhibitor that plays important role in the molecular pathways of senescence, which le...

    Authors: Xiyuan Zhang, Guanying Bianca Xu, Dan Zhou and Yuan-Xiang Pan

    Citation: Genes & Nutrition 2018 13:6

    Content type: Research

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  3. Variation in the fat mass and obesity-associated gene (FTO) has been associated with susceptibility to obesity, but the association appears to be modified by diet. We investigated whether dietary protein intake m...

    Authors: David C. Merritt, Joseph Jamnik and Ahmed El-Sohemy

    Citation: Genes & Nutrition 2018 13:4

    Content type: Research

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  4. Identification of new biomarkers of food and nutrient intake has developed fast over the past two decades and could potentially provide important new tools for compliance monitoring and dietary intake assessme...

    Authors: Giulia Praticò, Qian Gao, Augustin Scalbert, Guy Vergères, Marjukka Kolehmainen, Claudine Manach, Lorraine Brennan, Sri Harsha Pedapati, Lydia A. Afman, David S. Wishart, Rosa Vázquez-Fresno, Cristina Andres-Lacueva, Mar Garcia-Aloy, Hans Verhagen, Edith J. M. Feskens and Lars O. Dragsted

    Citation: Genes & Nutrition 2018 13:3

    Content type: Review

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  5. Vitamin B12 is an essential micronutrient in humans needed for health maintenance. Deficiency of vitamin B12 has been linked to dietary, environmental and genetic factors. Evidence for the genetic basis of vit...

    Authors: S. Surendran, A. Adaikalakoteswari, P. Saravanan, I. A. Shatwaan, J. A. Lovegrove and K. S. Vimaleswaran

    Citation: Genes & Nutrition 2018 13:2

    Content type: Review

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  6. Genetic polymorphisms of antioxidant enzymes CAT, GPX, and SOD are involved in the etiology of obesity and its principal comorbidities. The aim of the present study was to analyze the effect of aforementioned ...

    Authors: César Hernández-Guerrero, Alicia Parra-Carriedo, Diana Ruiz-de-Santiago, Oscar Galicia-Castillo, Mario Buenrostro-Jáuregui and Carmen Díaz-Gutiérrez

    Citation: Genes & Nutrition 2018 13:1

    Content type: Research

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  7. Nutrigenetic research examines the effects of inter-individual differences in genotype on responses to nutrients and other food components, in the context of health and of nutrient requirements. A practical ap...

    Authors: Keith A. Grimaldi, Ben van Ommen, Jose M. Ordovas, Laurence D. Parnell, John C. Mathers, Igor Bendik, Lorraine Brennan, Carlos Celis-Morales, Elisa Cirillo, Hannelore Daniel, Brenda de Kok, Ahmed El-Sohemy, Susan J. Fairweather-Tait, Rosalind Fallaize, Michael Fenech, Lynnette R. Ferguson…

    Citation: Genes & Nutrition 2017 12:35

    Content type: Review

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  8. Biomarkers are an efficient means to examine intakes or exposures and their biological effects and to assess system susceptibility. Aided by novel profiling technologies, the biomarker research field is underg...

    Authors: Qian Gao, Giulia Praticò, Augustin Scalbert, Guy Vergères, Marjukka Kolehmainen, Claudine Manach, Lorraine Brennan, Lydia A. Afman, David S. Wishart, Cristina Andres-Lacueva, Mar Garcia-Aloy, Hans Verhagen, Edith J. M. Feskens and Lars O. Dragsted

    Citation: Genes & Nutrition 2017 12:34

    Content type: Review

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  9. The inverse relationship between exercise capacity and its variation over time and both cardiovascular and all-cause mortality suggests the existence of an etiological nexus between cardiometabolic diseases an...

    Authors: Natalia Gomes Gonçalves, Stephanie Heffer Cavaletti, Carlos Augusto Pasqualucci, Milton Arruda Martins and Chin Jia Lin

    Citation: Genes & Nutrition 2017 12:33

    Content type: Research

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  10. A key feature of metabolic health is the ability to adapt upon dietary perturbations. A systemic review defined an optimal nutritional challenge test, the “PhenFlex test” (PFT). Recently, it has been shown tha...

    Authors: T. J. van den Broek, G. C. M. Bakker, C. M. Rubingh, S. Bijlsma, J. H. M. Stroeve, B. van Ommen, M. J. van Erk and S. Wopereis

    Citation: Genes & Nutrition 2017 12:32

    Content type: Research

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  11. We investigated whether the long-term consumption of a symbiotic formulation with Lactobacillus fermentum (probiotic) and β-glucan from cauliflower mushroom (prebiotic) would delay the progression of post-menopau...

    Authors: Seong-Yeop Jeong, Suna Kang, Cao Shi Hua, Zhang Ting and Sunmin Park

    Citation: Genes & Nutrition 2017 12:31

    Content type: Research

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  12. The solute carrier family 30 member 8 gene (SLC30A8) encodes a zinc transporter in the pancreatic beta cells and the major C-allele of a missense variant (rs13266634; C/T; R325W) in SLC30A8 is associated with an ...

    Authors: Isabel Drake, George Hindy, Ulrika Ericson and Marju Orho-Melander

    Citation: Genes & Nutrition 2017 12:30

    Content type: Research

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  13. A large number of genome-wide association studies, transferability studies, and candidate gene studies performed in diverse populations around the world have identified gene variants that are associated with c...

    Authors: Joseph J. Castillo, Robert A. Orlando and William S. Garver

    Citation: Genes & Nutrition 2017 12:29

    Content type: Review

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  14. During evolution, humans colonized different ecological niches and adopted a variety of subsistence strategies that gave rise to diverse selective pressures acting across the genome. Environmentally induced se...

    Authors: Silvia Parolo, Sébastien Lacroix, Jim Kaput and Marie-Pier Scott-Boyer

    Citation: Genes & Nutrition 2017 12:28

    Content type: Research

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  15. Dietary supplementation of essential amino acids (EAAs) has been shown to promote healthspan. EAAs regulate, in fact, glucose and lipid metabolism and energy balance, increase mitochondrial biogenesis, and mai...

    Authors: Francesco Bifari, Chiara Ruocco, Ilaria Decimo, Guido Fumagalli, Alessandra Valerio and Enzo Nisoli

    Citation: Genes & Nutrition 2017 12:27

    Content type: Review

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  16. Obesity, a major cause of death and disability, is increasing worldwide. Obesity is characterized by a chronic, low-grade inflammatory state which is suggested to play a critical role in the development of obe...

    Authors: Vibeke H. Telle-Hansen, Jacob J. Christensen, Stine M. Ulven and Kirsten B. Holven

    Citation: Genes & Nutrition 2017 12:26

    Content type: Review

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  17. Obesity is a complex pathology associated with dysbiosis, metabolic alterations, and low-grade chronic inflammation promoted by immune cells, infiltrating and populating the adipose tissue. Probiotic supplemen...

    Authors: Marianna Roselli, Chiara Devirgiliis, Paola Zinno, Barbara Guantario, Alberto Finamore, Rita Rami and Giuditta Perozzi

    Citation: Genes & Nutrition 2017 12:25

    Content type: Research

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  18. In the dietary and health research area, biomarkers are extensively used for multiple purposes. These include biomarkers of dietary intake and nutrient status, biomarkers used to measure the biological effects...

    Authors: Lars O. Dragsted, Qian Gao, Giulia Praticò, Claudine Manach, David S. Wishart, Augustin Scalbert and Edith J. M. Feskens

    Citation: Genes & Nutrition 2017 12:24

    Content type: Commentary

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  19. In recent years, the link between regulatory microRNAs (miRNAs) and diseases has been the object of intensive research. miRNAs have emerged as key mediators of metabolic processes, playing crucial roles in mai...

    Authors: Giuseppe Iacomino and Alfonso Siani

    Citation: Genes & Nutrition 2017 12:23

    Content type: Review

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  20. Methionine, a central molecule in one-carbon metabolism, is an essential amino acid required for normal growth and development. Despite its importance to biological systems, methionine is toxic when administer...

    Authors: Isabelle R. Miousse, Rupak Pathak, Sarita Garg, Charles M. Skinner, Stepan Melnyk, Oleksandra Pavliv, Howard Hendrickson, Reid D. Landes, Annie Lumen, Alan J. Tackett, Nicolaas E.P. Deutz, Martin Hauer-Jensen and Igor Koturbash

    Citation: Genes & Nutrition 2017 12:22

    Content type: Research

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  21. A key feature of metabolic health is the ability to adapt upon dietary perturbations. Recently, it was shown that metabolic challenge tests in combination with the new generation biomarkers allow the simultane...

    Authors: Suzan Wopereis, Johanna H. M. Stroeve, Annette Stafleu, Gertruud C. M. Bakker, Jacobus Burggraaf, Marjan J. van Erk, Linette Pellis, Ruud Boessen, Alwine A. F. Kardinaal and Ben van Ommen

    Citation: Genes & Nutrition 2017 12:21

    Content type: Research

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  22. The ability to digest lactose after weaning, namely, lactase persistence (LP), is encoded by polymorphisms in the MCM6 gene and varies widely in frequency among different human populations. Although, evolution of...

    Authors: Yosra Ben Halima, Rym Kefi, Marco Sazzini, Cristina Giuliani, Sara De Fanti, Chokri Nouali, Majdi Nagara, Giacomo Mengozzi, Sahar Elouej, Abdelmajid Abid, Henda Jamoussi, Lotfi Chouchane, Giovanni Romeo, Sonia Abdelhak and Donata Luiselli

    Citation: Genes & Nutrition 2017 12:20

    Content type: Research

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  23. A polymorphism in a gene may exert its effects on multiple phenotypes. The aim of this study is to explore the association of 10 metabolic syndrome candidate genes with excess weight and adiposity and evaluate...

    Authors: Angélica María Muñoz, Claudia María Velásquez, Gloria María Agudelo, Rosa Magdalena Uscátegui, Alejandro Estrada, Fredy Alonso Patiño, Beatriz Elena Parra, María Victoria Parra and Gabriel Bedoya

    Citation: Genes & Nutrition 2017 12:19

    Content type: Research

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  24. When a novel nutritional concept comes along, scientists become enthusiastic and start new explorations. In 2012, the field was enthralled with a study suggesting plant-based nucleic acid “information” acts as...

    Authors: Kendal D. Hirschi

    Citation: Genes & Nutrition 2017 12:16

    Content type: Editorial

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  25. In ancient lore, a bullet cast from silver is the only effective weapon against monsters. The uptake of active diet-derived microRNAs (miRNAs) in consumers may be the silver bullet long sought after in nutriti...

    Authors: Kenneth W. Witwer and Chen-Yu Zhang

    Citation: Genes & Nutrition 2017 12:15

    Content type: Discussion

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  26. Extracellular vesicles deliver a variety of cargos to recipient cells, including the delivery of cargos in dietary vesicles from bovine milk to non-bovine species. The rate of discovery in this important line ...

    Authors: Janos Zempleni

    Citation: Genes & Nutrition 2017 12:12

    Content type: Commentary

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  27. It is widely accepted that metabolic disorders, such as obesity, are closely linked to lifestyle and diet. Recently, the central role played by the intestinal microbiota in human metabolism and in progression ...

    Authors: Sabrina Duranti, Chiara Ferrario, Douwe van Sinderen, Marco Ventura and Francesca Turroni

    Citation: Genes & Nutrition 2017 12:18

    Content type: Review

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  28. Gene expression profiles of intestinal mucosa of chickens and pigs fed over long-term periods (days/weeks) with a diet rich in rye and a diet supplemented with zinc, respectively, or of chickens after a one-da...

    Authors: Marcel Hulst, Alfons Jansman, Ilonka Wijers, Arjan Hoekman, Stéphanie Vastenhouw, Marinus van Krimpen, Mari Smits and Dirkjan Schokker

    Citation: Genes & Nutrition 2017 12:11

    Content type: Research

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  29. To elucidate the effects of altered dietary carbohydrate and fat balance on liver and adipose tissue transcriptomes, 3-week-old rats were fed three kinds of diets: low-, moderate-, and high-fat diets (L, M, an...

    Authors: Mitsuru Tanaka, Akihito Yasuoka, Manae Shimizu, Yoshikazu Saito, Kei Kumakura, Tomiko Asakura and Toshitada Nagai

    Citation: Genes & Nutrition 2017 12:10

    Content type: Research

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  30. The dietary xanthophylls, lutein and zeaxanthin, accumulate in primate retina and brain, and emerging evidence indicates neural lutein content may be beneficial for cognition. Neural xanthophyll content in pri...

    Authors: Emily S. Mohn, John W. Erdman Jr., Martha Neuringer, Matthew J. Kuchan and Elizabeth J. Johnson

    Citation: Genes & Nutrition 2017 12:9

    Content type: Research

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  31. High-intensity exercise induces many metabolic responses. In is unknown whether the response in the peripheral blood mononuclear cells (PBMCs) reflects the response in skeletal muscle and whether mRNA expressi...

    Authors: Gyrd O. Gjevestad, Håvard Hamarsland, Truls Raastad, Inger Ottestad, Jacob J. Christensen, Kristin Eckardt, Christian A. Drevon, Anne S. Biong, Stine M. Ulven and Kirsten B. Holven

    Citation: Genes & Nutrition 2017 12:8

    Content type: Research

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  32. Androgens, the main male sex steroids, are the critical factors responsible for the development of the male phenotype during embryogenesis and for the achievement of sexual maturation and puberty. In adulthood...

    Authors: Daniele Marcoccia, Marco Pellegrini, Marco Fiocchetti, Stefano Lorenzetti and Maria Marino

    Citation: Genes & Nutrition 2017 12:6

    Content type: Review

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  33. Vitamins and carotenoids are key micronutrients facilitating the maintenance of health, as evidenced by the increased risk of disease with low intake. Optimal phenotypic flexibility, i.e., the ability to respo...

    Authors: Tim J. van den Broek, Bas H. A. Kremer, Marisa Marcondes Rezende, Femke P. M. Hoevenaars, Peter Weber, Ulrich Hoeller, Ben van Ommen and Suzan Wopereis

    Citation: Genes & Nutrition 2017 12:5

    Content type: Research

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  34. The level of omega-6 and omega-3 polyunsaturated fatty acids can affect many cellular systems and function via nuclear receptors or the bioactive lipid regulation of gene expression. The objective of this stud...

    Authors: Magdalena Ogłuszka, Agnieszka Szostak, Marinus F. W. te Pas, Ewa Poławska, Paweł Urbański, Tadeusz Blicharski, Chandra S. Pareek, Edyta Juszczuk-Kubiak, Jenelle R. Dunkelberger, Jarosław O. Horbańczuk and Mariusz Pierzchała

    Citation: Genes & Nutrition 2017 12:4

    Content type: Research

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  35. The complex physiology of living organisms represents a challenge for mechanistic understanding of the action of dietary bioactives in the human body and of their possible role in health and disease. Animal, c...

    Authors: Jim Kaput, Giuditta Perozzi, Marijana Radonjic and Fabio Virgili

    Citation: Genes & Nutrition 2017 12:3

    Content type: Editorial

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  36. Hepatic fatty acids (FAs) are modified through different metabolic pathways including elongation and desaturation. These processes are catalyzed by elongases and desaturases, respectively. Glucose, by transcri...

    Authors: Jagoda Drąg, Anna Goździalska, Małgorzata Knapik-Czajka, Anna Gawędzka, Katarzyna Gawlik and Jerzy Jaśkiewicz

    Citation: Genes & Nutrition 2017 12:2

    Content type: Research

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  37. Epidemiological studies suggest that hyponutrition during the fetal period increases the risk of mental disorders such as attention deficit hyperactivity disorder and autism-spectrum disorder, which has been e...

    Authors: Tamio Furuse, Kunio Miyake, Takashi Kohda, Hideki Kaneda, Takae Hirasawa, Ikuko Yamada, Tomoko Kushida, Misho Kashimura, Kimio Kobayashi, Fumitoshi Ishino, Takeo Kubota and Shigeharu Wakana

    Citation: Genes & Nutrition 2017 12:1

    Content type: Research

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  38. We have previously reported that γ- and δ-tocotrienols (γ- and δ-T3) induce gene expression and apoptosis in human breast cancer cells (MDA-MB-231 and MCF-7). This effect is mediated, at least in part, by a sp...

    Authors: Raffaella Comitato, Barbara Guantario, Guido Leoni, Kalanithi Nesaretnam, Maria Beatrice Ronci, Raffaella Canali and Fabio Virgili

    Citation: Genes & Nutrition 2016 11:32

    Content type: Research

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  39. Obesity is known to increase the risk of colorectal cancer. However, mechanisms underlying the pathogenesis of obesity-induced colorectal cancer are not completely understood. The purposes of this study were t...

    Authors: Yun Jung Bae, Sung-Eun Kim, Seong Yeon Hong, Taesun Park, Sang Gyu Lee, Myung-Sook Choi and Mi-Kyung Sung

    Citation: Genes & Nutrition 2016 11:30

    Content type: Research

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  40. The Nile rat (NR, Arvicanthis niloticus) is a model of carbohydrate-induced type 2 diabetes mellitus (T2DM) and the metabolic syndrome. A previous study found that palm fruit juice (PFJ) delayed or prevented diab...

    Authors: Soon-Sen Leow, Julia Bolsinger, Andrzej Pronczuk, K. C. Hayes and Ravigadevi Sambanthamurthi

    Citation: Genes & Nutrition 2016 11:29

    Content type: Research

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  41. Fetal exposure to a maternal low protein diet during rat pregnancy is associated with hypertension, renal dysfunction and metabolic disturbance in adult life. These effects are present when dietary manipulatio...

    Authors: Zoe Daniel, Angelina Swali, Richard Emes and Simon C Langley-Evans

    Citation: Genes & Nutrition 2016 11:27

    Content type: Research

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  42. The individual genetic variations, as a response to diet, have recently caught the attention of several researchers. In addition, there is also a trend to assume food containing beneficial substances, or to su...

    Authors: L. Della Casa, E. Rossi, C. Romanelli, L. Gibellini and A. Iannone

    Citation: Genes & Nutrition 2016 11:26

    Content type: Research

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  43. It is hypothesised that individuals with knowledge of their genetic risk are more likely to make health-promoting dietary and lifestyle changes. The present study aims to test this hypothesis using data from t...

    Authors: Clare B. O’Donovan, Marianne C. Walsh, Hannah Forster, Clara Woolhead, Carlos Celis-Morales, Rosalind Fallaize, Anna L. Macready, Cyril F. M. Marsaux, Santiago Navas-Carretero, Rodrigo San-Cristobal, Silvia Kolossa, Christina Mavrogianni, Christina P. Lambrinou, George Moschonis, Magdalena Godlewska, Agnieszka Surwillo…

    Citation: Genes & Nutrition 2016 11:25

    Content type: Research

    Published on:

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