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  1. Epigenetic and posttranslational modifications of the expression of cell cycle-relevant genes or proteins like p21, e.g., by miRNAs are crucial mechanisms in the development or prevention of colon cancer. The pr...

    Authors: W. Schlörmann, S. Naumann, C. Renner and M. Glei
    Citation: Genes & Nutrition 2015 10:50
    Content type: Research Paper Published on:

  2. Colorectal cancer (CRC) is a disease whose genesis may include metabolic dysregulation. Cancer stem cells are attractive targets for therapeutic interventions since their aberrant expansion may underlie tumor ...

    Authors: Maria Theresa E. Montales, Rosalia C. M. Simmen, Ederlan S. Ferreira, Valdir A. Neves and Frank A. Simmen
    Citation: Genes & Nutrition 2015 10:49
    Content type: Research Paper Published on:

  3. The hypothalamus integrates energy balance information from the periphery using different neuronal subtypes within each of the hypothalamic areas. However, the effects of prandial state on global mRNA, microRN...

    Authors: Hao Jiang, Thero Modise, Richard Helm, Roderick V. Jensen and Deborah J. Good
    Citation: Genes & Nutrition 2015 10:48
    Content type: Research Paper Published on:

  4. The inhibitory neurotransmitter GABA (γ-aminobutyric acid) is synthesized by glutamic acid decarboxylase, which is expressed in the central nervous system and in various other tissues including the intestine. ...

    Authors: Hannah-Sophie Braun, Gerhard Sponder, Robert Pieper, Jörg R. Aschenbach and Carolin Deiner
    Citation: Genes & Nutrition 2015 10:47
    Content type: Research Paper Published on:

  5. Obesity is associated with chronic diseases such as fatty liver, type 2 diabetes, cardiovascular disease, and severe metabolic syndrome. Obesity causes metabolic impairment including excessive lipid accumulat...

    Authors: Ji-Young Ann, Hyeyoon Eo and Yunsook Lim
    Citation: Genes & Nutrition 2015 10:46
    Content type: Research Paper Published on:

  7. The usefulness of zinc transporter and metallothionein (MT) gene expressions to detect changes in zinc intake remains unclear. This pilot study aimed to determine the effects of zinc supplementation on zinc tr...

    Authors: Anna Chu, Meika Foster, Sarah Ward, Kamrul Zaman, Dale Hancock, Peter Petocz and Samir Samman
    Citation: Genes & Nutrition 2015 10:44
    Content type: Research Paper Published on:

  8. Human and animal studies suggest an interaction between the Pro12Ala polymorphism of PPARG and dietary fat. In this randomized crossover clinical trial, we investigated whether subjects with the Pro12Pro and Ala...

    Authors: Jussi Pihlajamäki, Ursula Schwab, Dorota Kaminska, Jyrki Ågren, Johanna Kuusisto, Marjukka Kolehmainen, Jussi Paananen, Markku Laakso and Matti Uusitupa
    Citation: Genes & Nutrition 2015 10:43
    Content type: Research Paper Published on:

  9. Through a Privacy Calculus (i.e. risk–benefit trade-off) lens, this study identifies factors that contribute to consumers’ adoption of personalised nutrition services. We argue that consumers’ intention to ado...

    Authors: Aleksandra Berezowska, Arnout R. H. Fischer, Amber Ronteltap, Ivo A. van der Lans and Hans C. M. van Trijp
    Citation: Genes & Nutrition 2015 10:42
    Content type: Research Paper Published on:

  10. 18β-Glycyrrhetinic acid (18β-GA) has been proposed as a promising hepatoprotective agent. The current study aimed to investigate the protective action and the possible mechanisms of 18β-GA against cyclophospha...

    Authors: Ayman M. Mahmoud and Hussein S. Al Dera
    Citation: Genes & Nutrition 2015 10:41
    Content type: Research Paper Published on:

    The Erratum to this article has been published in Genes & Nutrition 2016 11:31

  12. We investigated the effect of short-term fasting on coordinate changes in the fatty acid composition of adipose triacylglycerol (TAG), serum non-esterified fatty acids (NEFA), liver TAG, and serum TAG and phos...

    Authors: Kristin A. Marks, Phillip M. Marvyn, Juan J. Aristizabal Henao, Ryan M. Bradley, Ken D. Stark and Robin E. Duncan
    Citation: Genes & Nutrition 2015 10:39
    Content type: Research Paper Published on:

    The Erratum to this article has been published in Genes & Nutrition 2015 10:45

  13. Two cases of zinc deficiency in breastfed neonates were investigated where zinc levels in the mothers’ milk were reduced by more than 75 % compared to normal. The objective of this study was to find the molec...

    Authors: Loveleen Kumar, Agnes Michalczyk, Jill McKay, Dianne Ford, Taiho Kambe, Lee Hudek, George Varigios, Philip E. Taylor and M. Leigh Ackland
    Citation: Genes & Nutrition 2015 10:38
    Content type: Research Paper Published on:

  14. Angiotensinogen (AGT), its active fragments and microRNA-31 (miR-31) play an important role in adipocyte differentiation. AGT contains a miR-31 polymorphic binding site. We hypothesize that the rs7079 polymorp...

    Authors: Jan Machal, Jan Novak, Renata Hezova, Filip Zlamal, Anna Vasku, Ondrej Slaby and Julie Bienertova-Vasku
    Citation: Genes & Nutrition 2015 10:37
    Content type: Research Paper Published on:

  16. Nutritional systems biology is an evolving research field aimed at understanding nutritional processes at a systems level. It is known that the development of cancer can be influenced by the nutritional status...

    Authors: Martina Kutmon, Susan L. Coort, Kim de Nooijer, Claire Lemmens and Chris T. Evelo
    Citation: Genes & Nutrition 2015 10:35
    Content type: Research Paper Published on:

  17. The aim of the study was to assess the relationship between sweet taste genes and dental caries prevalence in a large sample of adults. In addition, the association between sweet liking and sugar intake with ...

    Authors: Antonietta Robino, Lorenzo Bevilacqua, Nicola Pirastu, Roberta Situlin, Roberto Di Lenarda, Paolo Gasparini and Chiara Ottavia Navarra
    Citation: Genes & Nutrition 2015 10:34
    Content type: Research Paper Published on:

  19. Celiac disease is an intestinal disease which shows different symptoms and clinical manifestations among pediatric and adult patients. These variations could be imputable to age-related changes in gut architec...

    Authors: Gaia Buoli Comani, Roberto Panceri, Marco Dinelli, Andrea Biondi, Clara Mancuso, Raffaella Meneveri and Donatella Barisani
    Citation: Genes & Nutrition 2015 10:32
    Content type: Research Paper Published on:

  20. Type 2 diabetes (T2D) has become an increasingly challenging health burden due to its high morbidity, mortality, and heightened prevalence worldwide. Although dietary and nutritional imbalances have long been ...

    Authors: Yuqi Zhao, Rio Elizabeth Barrere-Cain and Xia Yang
    Citation: Genes & Nutrition 2015 10:31
    Content type: Research Paper Published on:

  21. Several dietary agents, such as micronutrient and non-nutrient components, the so-called bioactive food components, have been shown to display anticancer properties and influence genetic processes. The most co...

    Authors: Antonella Agodi, Martina Barchitta, Annalisa Quattrocchi, Andrea Maugeri, Carolina Canto, Anna Elisa Marchese and Manlio Vinciguerra
    Citation: Genes & Nutrition 2015 10:30
    Content type: Research Paper Published on:

  22. Nutritional therapy is well established as a means to induce remission in active Crohn’s disease (CD). Evidence indicates that exclusive enteral nutrition (EEN) therapy for CD both alters the intestinal microb...

    Authors: Lily Nahidi, Susan M. Corley, Marc R. Wilkins, Jerry Wei, Moftah Alhagamhmad, Andrew S. Day, Daniel A. Lemberg and Steven T. Leach
    Citation: Genes & Nutrition 2015 10:29
    Content type: Research Paper Published on:

  23. In e-health intervention studies, there are concerns about the reliability of internet-based, self-reported (SR) data and about the potential for identity fraud. This study introduced and tested a novel proced...

    Authors: Carlos Celis-Morales, Katherine M. Livingstone, Clara Woolhead, Hannah Forster, Clare B. O’Donovan, Anna L. Macready, Rosalind Fallaize, Cyril F. M. Marsaux, Lydia Tsirigoti, Eirini Efstathopoulou, George Moschonis, Santiago Navas-Carretero, Rodrigo San-Cristobal, Silvia Kolossa, Ulla L. Klein, Jacqueline Hallmann…
    Citation: Genes & Nutrition 2015 10:28
    Content type: Research Paper Published on:

  24. Food components with anti-obesity properties are commonly evaluated using mouse models of diet-induced obesity. The ability of these components to reduce or prevent white adipose tissue (WAT) accumulation is u...

    Authors: Anja Voigt, Joan Ribot, Agustín G. Sabater, Andreu Palou, M. Luisa Bonet and Susanne Klaus
    Citation: Genes & Nutrition 2015 10:27
    Content type: Research Paper Published on:

  25. The n-3 polyunsaturated fatty acids (PUFAs), EPA and DHA, as well as estrogen have been shown to decrease circulating levels of triglyceride (TG), but their underlying mode of action is unclear. The purpose o...

    Authors: Suhyun Kim, Youri Jin and Yongsoon Park
    Citation: Genes & Nutrition 2015 10:26
    Content type: Research Paper Published on:

  26. The incidence of iron deficiency anemia in pregnancy is high in India where iron supplementation is a regular practice. The response to oral iron is influenced by several factors such as age, body mass index,...

    Authors: Rekha Athiyarath, Kalaiselvi Shaktivel, Vinod Abraham, Daisy Singh, Joseph Dian Bondu, Aaron Chapla, Biju George, Alok Srivastava and Eunice Sindhuvi Edison
    Citation: Genes & Nutrition 2015 10:25
    Content type: Research Paper Published on:

  28. Dietary flavonoid intake is associated with reduced risk of cardiovascular diseases, possibly by affecting metabolic health. The relative potency of different flavonoids in causing beneficial effects on energy...

    Authors: Elise F. Hoek-van den Hil, Evert M. van Schothorst, Inge van der Stelt, Hans J. M. Swarts, Marjanne van Vliet, Tom Amolo, Jacques J. M. Vervoort, Dini Venema, Peter C. H. Hollman, Ivonne M. C. M. Rietjens and Jaap Keijer
    Citation: Genes & Nutrition 2015 10:23
    Content type: Research Paper Published on:

  29. Health is influenced by interplay of molecular, physiological and environmental factors. To effectively maintain health and prevent disease, health-relevant relations need to be understood at multiple levels o...

    Authors: Davina Derous, Thomas Kelder, Evert M. van Schothorst, Marjan van Erk, Anja Voigt, Susanne Klaus, Jaap Keijer and Marijana Radonjic
    Citation: Genes & Nutrition 2015 10:22
    Content type: Research Paper Published on:

  32. Healthy nutrition is accepted as a cornerstone of public health strategies for reducing the risk of noncommunicable conditions such as obesity, cardiovascular disease, and related morbidities. However, many re...

    Authors: Jacqueline Pontes Monteiro, Martin Kussmann and Jim Kaput
    Citation: Genes & Nutrition 2015 10:19
    Content type: Review Published on:

  33. Iron-deficient anemia is a prevalent disease among humans. We searched for genes regulated by iron deficiency and its regulated mechanism. cDNA microarrays were performed using Hepa1c1c7 cells treated with 10...

    Authors: Seung-Min Lee, Sun Bok Lee, Ron Prywes and Christopher D. Vulpe
    Citation: Genes & Nutrition 2015 10:18
    Content type: Research Paper Published on:

  35. Worldwide, the incidence of obesity has increased dramatically over the past decades. More knowledge about the complex etiology of obesity is needed in order to find additional approaches for treatment and pre...

    Authors: Edwin C. M. Mariman, Radek Szklarczyk, Freek G. Bouwman, Erik E. J. G. Aller, Marleen A. van Baak and Ping Wang
    Citation: Genes & Nutrition 2015 10:16
    Content type: Research Paper Published on:

  36. Recent studies have established the interaction between APOA2 −256T>C polymorphism and dietary saturated fatty acids intake in relation to obesity on healthy individuals. In the current study, we investigate the ...

    Authors: Marjan Ghane Basiri, Gity Sotoudeh, Ehsan Alvandi, Mahmood Djalali, Mohammad Reza Eshraghian, Neda Noorshahi and Fariba Koohdani
    Citation: Genes & Nutrition 2015 10:15
    Content type: Research Paper Published on:

  37. Iron homeostasis in the human body is maintained primarily through regulation of iron absorption in the duodenum. The liver peptide hepcidin plays a central role in this regulation. Additionally, expression a...

    Authors: J. J. Eady, Y. M. Wormstone, S. J. Heaton, B. Hilhorst and R. M. Elliott
    Citation: Genes & Nutrition 2015 10:14
    Content type: Research Paper Published on:

  38. Nutrition research is struggling to demonstrate beneficial health effects, since nutritional effects are often subtle and long term. Health has been redefined as the ability of our body to cope with daily-life...

    Authors: Johanna H. M. Stroeve, Herman van Wietmarschen, Bas H. A. Kremer, Ben van Ommen and Suzan Wopereis
    Citation: Genes & Nutrition 2015 10:13
    Content type: Research Paper Published on:

  39. Human and companion animal health depends upon nutritional quality of foods. Seed varieties, seasonal and local growing conditions, transportation, food processing, and storage, and local food customs can infl...

    Authors: Jim Kaput, Martin Kussmann, Yery Mendoza, Ronit Le Coutre, Karen Cooper and Anne Roulin
    Citation: Genes & Nutrition 2015 10:12
    Content type: Research Paper Published on:

  40. Inflammation is a critical contributor to the pathogenesis of metabolic disorders with adipose tissue being crucial in the inflammatory response by releasing multiple adipokines with either pro- or anti-inflam...

    Authors: Victoria Catalán, Javier Gómez-Ambrosi, Amaia Rodríguez, Beatriz Ramírez, Víctor Valentí, Rafael Moncada, Camilo Silva, Javier Salvador and Gema Frühbeck
    Citation: Genes & Nutrition 2015 10:11
    Content type: Research Paper Published on:

  41. To study host–probiotic interactions in parts of the intestine only accessible in humans by surgery (jejunum, ileum and colon), pigs were used as model for humans. Groups of eight 6-week-old pigs were repeated...

    Authors: Marcel Hulst, Gabriele Gross, Yaping Liu, Arjan Hoekman, Theo Niewold, Jan van der Meulen and Mari Smits
    Citation: Genes & Nutrition 2015 10:10
    Content type: Research Paper Published on:

  42. Authors: Wanjiku N. Gichohi-Wainaina, G. Wayne Towers, Dorine W. Swinkels, Michael B. Zimmermann, Edith J. Feskens and Alida Melse-Boonstra
    Citation: Genes & Nutrition 2015 10:9
    Content type: Erratum Published on:

    The original article was published in Genes & Nutrition 2014 10:442

  43. Genetic predisposition and environmental challenges interact to determine individual vulnerability to obesity and type 2 diabetes. We previously established a mouse model of chronic subordination stress-induce...

    Authors: Maria Razzoli, Jacob McCallum, Allison Gurney, William C. Engeland and Alessandro Bartolomucci
    Citation: Genes & Nutrition 2015 10:8
    Content type: Research Paper Published on:

  44. Data on the effect of combined genetic polymorphisms, involved in folate metabolism, on the concentration of serum folate after folic acid supplementation are scarce. Therefore, we investigated the impact of s...

    Authors: Rona Cabo, Sigrunn Hernes, Audun Slettan, Margaretha Haugen, Shu Ye, Rune Blomhoff and M. Azam Mansoor
    Citation: Genes & Nutrition 2015 10:7
    Content type: Research Paper Published on:

  45. Black carrots (Daucus carota L.) are rich in anthocyanins which contribute many health benefits, but are limited by bioavailability and instability when exposed to oxygen, heat and light. Fermenting black carrots...

    Authors: Sunmin Park, Suna Kang, Do-Youn Jeong, Seong-Yeop Jeong, Jae Jung Park and Ho Sik Yun
    Citation: Genes & Nutrition 2015 10:6
    Content type: Research Paper Published on:

  46. Single-nucleotide polymorphisms (SNPs) within genes of the one-carbon metabolism pathway have been shown to interact with dietary folate intake to modify breast cancer (BC) risk. Our group has previously demon...

    Authors: Maria G. Kakkoura, Christiana A. Demetriou, Maria A. Loizidou, Giorgos Loucaides, Ioanna Neophytou, Yiola Marcou, Andreas Hadjisavvas and Kyriacos Kyriacou
    Citation: Genes & Nutrition 2015 10:5
    Content type: Research Paper Published on:

  47. Large-scale meta-analyses of genome-wide association studies have recently confirmed that the rs340874 single-nucleotide polymorphism in PROX1 gene is associated with fasting glycemia and type 2 diabetes mellitus...

    Authors: Adam Kretowski, Edyta Adamska, Katarzyna Maliszewska, Natalia Wawrusiewicz-Kurylonek, Anna Citko, Joanna Goscik, Witold Bauer, Juliusz Wilk, Anna Golonko, Magdalena Waszczeniuk, Danuta Lipinska, Justyna Hryniewicka, Magdalena Niemira, Magdalena Paczkowska, Michal Ciborowski and Maria Gorska
    Citation: Genes & Nutrition 2015 10:4
    Content type: Research Paper Published on:

  48. The liver is the main organ involved in the metabolism of amino acids (AA), which are oxidized by amino acid catabolizing enzymes (AACE). Peroxisome proliferator-activated receptor-α (PPARα) stimulates fatty a...

    Authors: Alejandra V. Contreras, Claudia Rangel-Escareño, Nimbe Torres, Gabriela Alemán-Escondrillas, Victor Ortiz, Lilia G. Noriega, Ivan Torre-Villalvazo, Omar Granados, Laura A. Velázquez-Villegas, Sandra Tobon-Cornejo, Diana González-Hirschfeld, Félix Recillas-Targa, Elizabeth Tejero-Barrera, Frank J. Gonzalez and Armando R. Tovar
    Citation: Genes & Nutrition 2015 10:3
    Content type: Research Paper Published on:

  49. Red onions and low doses of the flavonoid, quercetin, increase insulin sensitivity and improve glucose tolerance. We hypothesized that dietary supplementation with red onion extract (RO) would attenuate high f...

    Authors: T. M. Henagan, W. T. Cefalu, D. M. Ribnicky, R. C. Noland, K. Dunville, W. W. Campbell, L. K. Stewart, L. A. Forney, T. W. Gettys, J. S. Chang and C. D. Morrison
    Citation: Genes & Nutrition 2014 10:2
    Content type: Research Paper Published on:

  50. The beneficial effects of adiponectin and its negative correlation with BMI are well described. Adiponectin serum levels are altered in eating disorders such as anorexia nervosa, bulimia nervosa or binge eati...

    Authors: Kerstin Rohde, Maria Keller, Annette Horstmann, Xuanshi Liu, Fabian Eichelmann, Michael Stumvoll, Arno Villringer, Peter Kovacs, Anke Tönjes and Yvonne Böttcher
    Citation: Genes & Nutrition 2014 10:1
    Content type: Research Paper Published on:
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