Articles

Use of miRNAs in biofluids as biomarkers in dietary and lifestyle intervention studies

The selection of biomarkers in nutrigenomics needs to reflect subtle changes in homoeostasis representing the relation between nutrition and health, or nutrition and disease. It is believed that noncoding RNA...

Authors: Sophie Rome

miRNA-regulated gene expression differs in celiac disease patients according to the age of presentation

Celiac disease is an intestinal disease which shows different symptoms and clinical manifestations among pediatric and adult patients. These variations could be imputable to age-related changes in gut architec...

Authors: Gaia Buoli Comani, Roberto Panceri, Marco Dinelli, Andrea Biondi, Clara Mancuso, Raffaella Meneveri and Donatella Barisani

Nutritional systems biology of type 2 diabetes

Type 2 diabetes (T2D) has become an increasingly challenging health burden due to its high morbidity, mortality, and heightened prevalence worldwide. Although dietary and nutritional imbalances have long been ...

Authors: Yuqi Zhao, Rio Elizabeth Barrere-Cain and Xia Yang

Low fruit consumption and folate deficiency are associated with LINE-1 hypomethylation in women of a cancer-free population

Several dietary agents, such as micronutrient and non-nutrient components, the so-called bioactive food components, have been shown to display anticancer properties and influence genetic processes. The most co...

Authors: Antonella Agodi, Martina Barchitta, Annalisa Quattrocchi, Andrea Maugeri, Carolina Canto, Anna Elisa Marchese and Manlio Vinciguerra

The major pathway by which polymeric formula reduces inflammation in intestinal epithelial cells: a microarray-based analysis

Nutritional therapy is well established as a means to induce remission in active Crohn’s disease (CD). Evidence indicates that exclusive enteral nutrition (EEN) therapy for CD both alters the intestinal microb...

Authors: Lily Nahidi, Susan M. Corley, Marc R. Wilkins, Jerry Wei, Moftah Alhagamhmad, Andrew S. Day, Daniel A. Lemberg and Steven T. Leach

How reliable is internet-based self-reported identity, socio-demographic and obesity measures in European adults?

In e-health intervention studies, there are concerns about the reliability of internet-based, self-reported (SR) data and about the potential for identity fraud. This study introduced and tested a novel proced...

Authors: Carlos Celis-Morales, Katherine M. Livingstone, Clara Woolhead, Hannah Forster, Clare B. O’Donovan, Anna L. Macready, Rosalind Fallaize, Cyril F. M. Marsaux, Lydia Tsirigoti, Eirini Efstathopoulou, George Moschonis, Santiago Navas-Carretero, Rodrigo San-Cristobal, Silvia Kolossa, Ulla L. Klein, Jacqueline Hallmann…

Identification of Mest/Peg1 gene expression as a predictive biomarker of adipose tissue expansion sensitive to dietary anti-obesity interventions

Food components with anti-obesity properties are commonly evaluated using mouse models of diet-induced obesity. The ability of these components to reduce or prevent white adipose tissue (WAT) accumulation is u...

Authors: Anja Voigt, Joan Ribot, Agustín G. Sabater, Andreu Palou, M. Luisa Bonet and Susanne Klaus

Estrogen and n-3 polyunsaturated fatty acid supplementation have a synergistic hypotriglyceridemic effect in ovariectomized rats

The n-3 polyunsaturated fatty acids (PUFAs), EPA and DHA, as well as estrogen have been shown to decrease circulating levels of triglyceride (TG), but their underlying mode of action is unclear. The purpose o...

Authors: Suhyun Kim, Youri Jin and Yongsoon Park

Association of genetic variants with response to iron supplements in pregnancy

The incidence of iron deficiency anemia in pregnancy is high in India where iron supplementation is a regular practice. The response to oral iron is influenced by several factors such as age, body mass index,...

Authors: Rekha Athiyarath, Kalaiselvi Shaktivel, Vinod Abraham, Daisy Singh, Joseph Dian Bondu, Aaron Chapla, Biju George, Alok Srivastava and Eunice Sindhuvi Edison

Erratum to: Maternal dietary intake of folate, vitamin B₁₂ and MTHFR 677C>T genotype: their impact on newborn’s anthropometric parameters

Authors: Luisa Torres-Sánchez, Lizbeth López-Carrillo, Julia Blanco-Muñoz and Jia Chen

Direct comparison of metabolic health effects of the flavonoids quercetin, hesperetin, epicatechin, apigenin and anthocyanins in high-fat-diet-fed mice

Dietary flavonoid intake is associated with reduced risk of cardiovascular diseases, possibly by affecting metabolic health. The relative potency of different flavonoids in causing beneficial effects on energy...

Authors: Elise F. Hoek-van den Hil, Evert M. van Schothorst, Inge van der Stelt, Hans J. M. Swarts, Marjanne van Vliet, Tom Amolo, Jacques J. M. Vervoort, Dini Venema, Peter C. H. Hollman, Ivonne M. C. M. Rietjens and Jaap Keijer

Network-based integration of molecular and physiological data elucidates regulatory mechanisms underlying adaptation to high-fat diet

Health is influenced by interplay of molecular, physiological and environmental factors. To effectively maintain health and prevent disease, health-relevant relations need to be understood at multiple levels o...

Authors: Davina Derous, Thomas Kelder, Evert M. van Schothorst, Marjan van Erk, Anja Voigt, Susanne Klaus, Jaap Keijer and Marijana Radonjic

The diet-induced metabolic syndrome is accompanied by whole-genome epigenetic changes

Consuming a high-fat/high-fructose diet (HFD) starting at a young age leads to the development of obesity and to the progression of metabolic syndrome (MS). We are interested in the relationship between MS an...

Authors: Irais Sánchez, Rosalia Reynoso-Camacho and Luis M. Salgado

The art of targeting gut microbiota for tackling human obesity

Recently, a great deal of interest has been expressed regarding strategies to tackle worldwide obesity because of its accelerated wide spread accompanied with numerous negative effects on health and high costs...

Authors: Marisol Aguirre and Koen Venema

The genomics of micronutrient requirements

Healthy nutrition is accepted as a cornerstone of public health strategies for reducing the risk of noncommunicable conditions such as obesity, cardiovascular disease, and related morbidities. However, many re...

Authors: Jacqueline Pontes Monteiro, Martin Kussmann and Jim Kaput

Iron deficiency upregulates Egr1 expression

Iron-deficient anemia is a prevalent disease among humans. We searched for genes regulated by iron deficiency and its regulated mechanism. cDNA microarrays were performed using Hepa1c1c7 cells treated with 10...

Authors: Seung-Min Lee, Sun Bok Lee, Ron Prywes and Christopher D. Vulpe

β-Carotene-induced apoptosis is mediated with loss of Ku proteins in gastric cancer AGS cells

High dietary intakes and high blood levels of β-carotene are associated with a decreased incidence of various cancers. The anticancer effect of β-carotene is related to its pro-oxidant activity. DNA repair Ku ...

Authors: Yoona Park, Jiyeon Choi, Joo Weon Lim and Hyeyoung Kim

Olfactory receptor genes cooperate with protocadherin genes in human extreme obesity

Worldwide, the incidence of obesity has increased dramatically over the past decades. More knowledge about the complex etiology of obesity is needed in order to find additional approaches for treatment and pre...

Authors: Edwin C. M. Mariman, Radek Szklarczyk, Freek G. Bouwman, Erik E. J. G. Aller, Marleen A. van Baak and Ping Wang

APOA2 −256T>C polymorphism interacts with saturated fatty acids intake to affect anthropometric and hormonal variables in type 2 diabetic patients

Recent studies have established the interaction between APOA2 −256T>C polymorphism and dietary saturated fatty acids intake in relation to obesity on healthy individuals. In the current study, we investigate the ...

Authors: Marjan Ghane Basiri, Gity Sotoudeh, Ehsan Alvandi, Mahmood Djalali, Mohammad Reza Eshraghian, Neda Noorshahi and Fariba Koohdani

Differential effects of basolateral and apical iron supply on iron transport in Caco-2 cells

Iron homeostasis in the human body is maintained primarily through regulation of iron absorption in the duodenum. The liver peptide hepcidin plays a central role in this regulation. Additionally, expression a...

Authors: J. J. Eady, Y. M. Wormstone, S. J. Heaton, B. Hilhorst and R. M. Elliott

Phenotypic flexibility as a measure of health: the optimal nutritional stress response test

Nutrition research is struggling to demonstrate beneficial health effects, since nutritional effects are often subtle and long term. Health has been redefined as the ability of our body to cope with daily-life...

Authors: Johanna H. M. Stroeve, Herman van Wietmarschen, Bas H. A. Kremer, Ben van Ommen and Suzan Wopereis

Enabling nutrient security and sustainability through systems research

Human and companion animal health depends upon nutritional quality of foods. Seed varieties, seasonal and local growing conditions, transportation, food processing, and storage, and local food customs can infl...

Authors: Jim Kaput, Martin Kussmann, Yery Mendoza, Ronit Le Coutre, Karen Cooper and Anne Roulin

Peripheral mononuclear blood cells contribute to the obesity-associated inflammatory state independently of glycemic status: involvement of the novel proinflammatory adipokines chemerin, chitinase-3-like protein 1, lipocalin-2 and osteopontin

Inflammation is a critical contributor to the pathogenesis of metabolic disorders with adipose tissue being crucial in the inflammatory response by releasing multiple adipokines with either pro- or anti-inflam...

Authors: Victoria Catalán, Javier Gómez-Ambrosi, Amaia Rodríguez, Beatriz Ramírez, Víctor Valentí, Rafael Moncada, Camilo Silva, Javier Salvador and Gema Frühbeck

Oral administration of Lactobacillus plantarum 299v modulates gene expression in the ileum of pigs: prediction of crosstalk between intestinal immune cells and sub-mucosal adipocytes

To study host–probiotic interactions in parts of the intestine only accessible in humans by surgery (jejunum, ileum and colon), pigs were used as model for humans. Groups of eight 6-week-old pigs were repeated...

Authors: Marcel Hulst, Gabriele Gross, Yaping Liu, Arjan Hoekman, Theo Niewold, Jan van der Meulen and Mari Smits

Erratum to: Inter-ethnic differences in genetic variants within the transmembrane protease, serine 6 (TMPRSS6) gene associated with iron status indicators: a systematic review with meta-analyses

Authors: Wanjiku N. Gichohi-Wainaina, G. Wayne Towers, Dorine W. Swinkels, Michael B. Zimmermann, Edith J. Feskens and Alida Melse-Boonstra

Chronic stress aggravates glucose intolerance in leptin receptor-deficient (db/db) mice

Genetic predisposition and environmental challenges interact to determine individual vulnerability to obesity and type 2 diabetes. We previously established a mouse model of chronic subordination stress-induce...

Authors: Maria Razzoli, Jacob McCallum, Allison Gurney, William C. Engeland and Alessandro Bartolomucci

Effect of genetic polymorphisms involved in folate metabolism on the concentration of serum folate and plasma total homocysteine (p-tHcy) in healthy subjects after short-term folic acid supplementation: a randomized, double blind, crossover study

Data on the effect of combined genetic polymorphisms, involved in folate metabolism, on the concentration of serum folate after folic acid supplementation are scarce. Therefore, we investigated the impact of s...

Authors: Rona Cabo, Sigrunn Hernes, Audun Slettan, Margaretha Haugen, Shu Ye, Rune Blomhoff and M. Azam Mansoor

Cyanidin and malvidin in aqueous extracts of black carrots fermented with Aspergillus oryzae prevent the impairment of energy, lipid and glucose metabolism in estrogen-deficient rats by AMPK activation

Black carrots (Daucus carota L.) are rich in anthocyanins which contribute many health benefits, but are limited by bioavailability and instability when exposed to oxygen, heat and light. Fermenting black carrots...

Authors: Sunmin Park, Suna Kang, Do-Youn Jeong, Seong-Yeop Jeong, Jae Jung Park and Ho Sik Yun

Single-nucleotide polymorphisms in one-carbon metabolism genes, Mediterranean diet and breast cancer risk: a case–control study in the Greek-Cypriot female population

Single-nucleotide polymorphisms (SNPs) within genes of the one-carbon metabolism pathway have been shown to interact with dietary folate intake to modify breast cancer (BC) risk. Our group has previously demon...

Authors: Maria G. Kakkoura, Christiana A. Demetriou, Maria A. Loizidou, Giorgos Loucaides, Ioanna Neophytou, Yiola Marcou, Andreas Hadjisavvas and Kyriacos Kyriacou

The rs340874 PROX1 type 2 diabetes mellitus risk variant is associated with visceral fat accumulation and alterations in postprandial glucose and lipid metabolism

Large-scale meta-analyses of genome-wide association studies have recently confirmed that the rs340874 single-nucleotide polymorphism in PROX1 gene is associated with fasting glycemia and type 2 diabetes mellitus...

Authors: Adam Kretowski, Edyta Adamska, Katarzyna Maliszewska, Natalia Wawrusiewicz-Kurylonek, Anna Citko, Joanna Goscik, Witold Bauer, Juliusz Wilk, Anna Golonko, Magdalena Waszczeniuk, Danuta Lipinska, Justyna Hryniewicka, Magdalena Niemira, Magdalena Paczkowska, Michal Ciborowski and Maria Gorska

PPARα via HNF4α regulates the expression of genes encoding hepatic amino acid catabolizing enzymes to maintain metabolic homeostasis

The liver is the main organ involved in the metabolism of amino acids (AA), which are oxidized by amino acid catabolizing enzymes (AACE). Peroxisome proliferator-activated receptor-α (PPARα) stimulates fatty a...

Authors: Alejandra V. Contreras, Claudia Rangel-Escareño, Nimbe Torres, Gabriela Alemán-Escondrillas, Victor Ortiz, Lilia G. Noriega, Ivan Torre-Villalvazo, Omar Granados, Laura A. Velázquez-Villegas, Sandra Tobon-Cornejo, Diana González-Hirschfeld, Félix Recillas-Targa, Elizabeth Tejero-Barrera, Frank J. Gonzalez and Armando R. Tovar

In vivo effects of dietary quercetin and quercetin-rich red onion extract on skeletal muscle mitochondria, metabolism, and insulin sensitivity

Red onions and low doses of the flavonoid, quercetin, increase insulin sensitivity and improve glucose tolerance. We hypothesized that dietary supplementation with red onion extract (RO) would attenuate high f...

Authors: T. M. Henagan, W. T. Cefalu, D. M. Ribnicky, R. C. Noland, K. Dunville, W. W. Campbell, L. K. Stewart, L. A. Forney, T. W. Gettys, J. S. Chang and C. D. Morrison

Role of genetic variants in ADIPOQ in human eating behavior

The beneficial effects of adiponectin and its negative correlation with BMI are well described. Adiponectin serum levels are altered in eating disorders such as anorexia nervosa, bulimia nervosa or binge eati...

Authors: Kerstin Rohde, Maria Keller, Annette Horstmann, Xuanshi Liu, Fabian Eichelmann, Michael Stumvoll, Arno Villringer, Peter Kovacs, Anke Tönjes and Yvonne Böttcher

γ-Glutamyl hydrolase modulation significantly influences global and gene-specific DNA methylation and gene expression in human colon and breast cancer cells

γ-Glutamyl hydrolase (GGH) plays an important role in folate homeostasis by catalyzing hydrolysis of polyglutamylated folate into monoglutamates. Polyglutamylated folates are better substrates for several enzy...

Authors: Sung-Eun Kim, Toshinori Hinoue, Michael S. Kim, Kyoung-Jin Sohn, Robert C. Cho, Peter D. Cole, Daniel J. Weisenberger, Peter W. Laird and Young-In Kim

Design and baseline characteristics of the Food4Me study: a web-based randomised controlled trial of personalised nutrition in seven European countries

Improving lifestyle behaviours has considerable potential for reducing the global burden of non-communicable diseases, promoting better health across the life-course and increasing well-being. However, realis...

Authors: Carlos Celis-Morales, Katherine M. Livingstone, Cyril F. M. Marsaux, Hannah Forster, Clare B. O’Donovan, Clara Woolhead, Anna L. Macready, Rosalind Fallaize, Santiago Navas-Carretero, Rodrigo San-Cristobal, Silvia Kolossa, Kai Hartwig, Lydia Tsirigoti, Christina P. Lambrinou, George Moschonis, Magdalena Godlewska…

Interactions between meat intake and genetic variation in relation to colorectal cancer

Meat intake is associated with the risk of colorectal cancer. The objective of this systematic review was to evaluate interactions between meat intake and genetic variation in order to identify biological path...

Authors: Vibeke Andersen and Ulla Vogel

Dietary inflammatory index and inflammatory gene interactions in relation to colorectal cancer risk in the Bellvitge colorectal cancer case–control study

Chronic inflammation is an important factor in colorectal carcinogenesis. However, evidence on the effect of pro-inflammatory and anti-inflammatory foods and nutrients is scarce. Moreover, there are few studie...

Authors: Raul Zamora-Ros, Nitin Shivappa, Susan E. Steck, Federico Canzian, Stefano Landi, M. Henar Alonso, James R. Hébert and Victor Moreno

White adipose tissue reference network: a knowledge resource for exploring health-relevant relations

Optimal health is maintained by interaction of multiple intrinsic and environmental factors at different levels of complexity—from molecular, to physiological, to social. Understanding and quantification of t...

Authors: Thomas Kelder, Georg Summer, Martien Caspers, Evert M. van Schothorst, Jaap Keijer, Loes Duivenvoorde, Susanne Klaus, Anja Voigt, Laura Bohnert, Catalina Pico, Andreu Palou, M. Luisa Bonet, Aldona Dembinska-Kiec, Malgorzata Malczewska-Malec, Beata Kieć-Wilk, Josep M. del Bas…

Nutritional B vitamin deficiency alters the expression of key proteins associated with vascular smooth muscle cell proliferation and migration in the aorta of atherosclerotic apolipoprotein E null mice

Low B vitamin status is linked with human vascular disease. We employed a proteomic and biochemical approach to determine whether nutritional folate deficiency and/or hyperhomocysteinemia altered metabolic pr...

Authors: Susan J. Duthie, John H. Beattie, Margaret-J. Gordon, Lynn P. Pirie, Fergus Nicol, Martin D. Reid, Gary J. Duncan, Louise Cantlay, Graham Horgan and Christopher J. McNeil

A genetic risk tool for obesity predisposition assessment and personalized nutrition implementation based on macronutrient intake

There is little evidence about genetic risk score (GRS)–diet interactions in order to provide personalized nutrition based on the genotype. The aim of the study was to assess the value of a GRS on obesity pred...

Authors: Leticia Goni, Marta Cuervo, Fermín I. Milagro and J. Alfredo Martínez

Effects of strain and age on hepatic gene expression profiles in murine models of HFE-associated hereditary hemochromatosis

Hereditary hemochromatosis is an iron overload disorder most commonly caused by a defect in the HFE gene. While the genetic defect is highly prevalent, the majority of individuals do not develop clinically signif...

Authors: Seung-Min Lee, Alexandre Loguinov, Robert E. Fleming and Christopher D. Vulpe

Inter-ethnic differences in genetic variants within the transmembrane protease, serine 6 (TMPRSS6) gene associated with iron status indicators: a systematic review with meta-analyses

Transmembrane protease, serine 6 (TMPRSS6), is likely to be involved in iron metabolism through its pleiotropic effect on hepcidin concentrations. Recently, genome-wide association studies have identified common...

Authors: Wanjiku N. Gichohi-Wainaina, G. Wayne Towers, Dorine W. Swinkels, Michael B. Zimmermann, Edith J. Feskens and Alida Melse-Boonstra

The impact of free or standardized lifestyle and urine sampling protocol on metabolome recognition accuracy

Urine contains a clear individual metabolic signature, although embedded within a large daily variability. Given the potential of metabolomics to monitor disease onset from deviations from the “healthy” metabo...

Authors: Sandra Wallner-Liebmann, Ewa Gralka, Leonardo Tenori, Manuela Konrad, Peter Hofmann, Martina Dieber-Rotheneder, Paola Turano, Claudio Luchinat and Kurt Zatloukal

TNF-α gene expression is increased following zinc supplementation in type 2 diabetes mellitus

Chronic low-grade inflammation in type 2 diabetes mellitus (DM) can elicit changes in whole-body zinc metabolism. The interaction among the expression of inflammatory cytokines, zinc transporter and metallothi...

Authors: Anna Chu, Meika Foster, Dale Hancock, Kim Bell-Anderson, Peter Petocz and Samir Samman

The intake of a high-fat diet and grape seed procyanidins induces gene expression changes in peripheral blood mononuclear cells of hamsters: capturing alterations in lipid and cholesterol metabolisms

We previously demonstrated that hamsters that were fed either a standard diet (STD) or a high-fat diet (HFD) and treated with a grape seed procyanidin extract (GSPE) showed decreased adiposity and circulating ...

Authors: Antoni Caimari, Anna Crescenti, Francesc Puiggròs, Noemí Boqué, Lluís Arola and Josep Maria del Bas

Effects of FADS and ELOVL polymorphisms on indexes of desaturase and elongase activities: results from a pre-post fish oil supplementation

Polymorphisms (SNPs) within the FADS gene cluster and the ELOVL gene family are believed to influence enzyme activities after an omega-3 (n-3) fatty acid (FA) supplementation. The objectives of the study are to ...

Authors: Hubert Cormier, Iwona Rudkowska, Simone Lemieux, Patrick Couture, Pierre Julien and Marie-Claude Vohl

Zinc proteome interaction network as a model to identify nutrient-affected pathways in human pathologies

Zinc is an essential micronutrient playing fundamental roles in cellular metabolism. It acts mostly through binding a wide range of proteins, thus affecting a broad spectrum of biological processes, which incl...

Authors: Guido Leoni, Antonio Rosato, Giuditta Perozzi and Chiara Murgia

Riboflavin status modifies the effects of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) polymorphisms on homocysteine

Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR), riboflavin-dependent enzymes, participate in homocysteine metabolism. Reported effects of riboflavin status on the associat...

Authors: Carlos J. García-Minguillán, Joan D. Fernandez-Ballart, Santiago Ceruelo, Lídia Ríos, Olalla Bueno, Maria Isabel Berrocal-Zaragoza, Anne M. Molloy, Per M. Ueland, Klaus Meyer and Michelle M. Murphy

Gender-specific genetic associations of polymorphisms in ACE, AKR1C2, FTO and MMP2 with weight gain over a 10-year period

Weight gain, when it leads to overweight or obesity, is nowadays one of the major health problems. ACE, FTO, AKR1C2, TIMP4 and MMP2 genes have been implicated in previous studies on weight regulation. This stu...

Authors: Freek G. Bouwman, Jolanda M. A. Boer, Sandra Imholz, Ping Wang, W. M. Monique Verschuren, Martijn E. T. Dollé and Edwin C. M. Mariman

Genetic variation in the hTAS2R38 taste receptor and food consumption among Finnish adults

Genetic variation in bitter taste receptors, such as hTAS2R38, may affect food preferences and intake. The aim of the present study was to investigate the association between bitter taste receptor haplotypes and ...

Authors: Mari Sandell, Ulla Hoppu, Vera Mikkilä, Nina Mononen, Mika Kähönen, Satu Männistö, Tapani Rönnemaa, Jorma Viikari, Terho Lehtimäki and Olli T. Raitakari